No Association Between Structural Properties of Corpus Callosum and Handedness: Evidence from the Constrained Spherical Deconvolution Approach

The Russian Journal of Cognitive Science. 2020. Vol. 7. No. 3. P. 68–77.

Karpychev V., Bolgina T., Malyutina S., Zinchenko V., Ushakov V., Ignatyev G., Dragoy O.

Handedness is the most prominent trait of functional asymmetry in humans, associated with lateralized cognitive functions and considered in relation to mental disorders. However, the neuroanatomical correlates of handedness are still unclear. It has been hypothesized that the structural properties of sub-regions of the corpus callosum (CC) are linked to handedness. Nevertheless, tractography studies of the relation between directly measured structural properties of CC subregions and handedness are lacking. The Constrained Spherical Deconvolution (CSD) approach enables full reconstruction of the sub-regions of the CC. The current study aimed to investigate the relation between the structural properties of the CC, such as volume and the CSD metric, referred to as hindrance modulated orientational anisotropy (HMOA), and handedness. Handedness was considered in two dimensions: direction (right-handed, ambidextrous, left-handed) and degree (the absolute values of Handedness quotient). We found no association between 1) volume or HMOA as a proxy of microstructural properties, namely the axonal diameter and fiber dispersion, of each sub-region and 2) either the direction or the degree of handedness. These findings suggest the absence of a direct relation between sub-regions of the CC and handedness, demonstrating the necessity of future tractography studies.

Keywords: трактография, corpus callosum, Tractography, functional asymmetry, handedness, constrained spherical deconvolution, функциональная асимметрия, мануальная асимметрия, мозолистое тело, ограниченная сферическая деконволюция