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Структурные особенности таламо-кортикальной системы и спектральные характеристики альфа-ритма у психически здоровых людей и больных шизофренией
Existing knowledge on morphological and functional abnormalities in thalamocortical system (TCS) in
schizophrenia are incomplete and inconsistent. To study TСS, we recruited 23 young male patients with
schizophrenia and 30 healthy males that underwent structural MRI, diffusion-weighted MRI and EEG. We
found structural abnormalities in the anterior and posterior thalamic radiations, in multiple fronto-parietal
cortical regions and thalamus as well as decrease of α-power in 11–12.5 Hz sub-band in schizophrenia pa-
tients compared with healthy controls. Correlations between reduced thickness in the medial prefrontal cor-
tex and structural abnormalities in thalamus and anterior thalamic radiation (in right hemisphere) were iden-
tified. Our results provide further evidence that widespread TCS structural abnormalities occur in the early
stages of schizophrenia.