• A
  • A
  • A
  • АБВ
  • АБВ
  • АБВ
  • A
  • A
  • A
  • A
  • A
Обычная версия сайта
  • RU
  • EN
  • HSE University
  • Publications
  • Articles
  • Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction
  • RU
  • EN
Расширенный поиск
Высшая школа экономики
Национальный исследовательский университет
Priority areas
  • business informatics
  • economics
  • engineering science
  • humanitarian
  • IT and mathematics
  • law
  • management
  • mathematics
  • sociology
  • state and public administration
by year
  • 2028
  • 2027
  • 2026
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007
  • 2006
  • 2005
  • 2004
  • 2003
  • 2002
  • 2001
  • 2000
  • 1999
  • 1998
  • 1997
  • 1996
  • 1995
  • 1994
  • 1993
  • 1992
  • 1991
  • 1990
  • 1989
  • 1988
  • 1987
  • 1986
  • 1985
  • 1984
  • 1983
  • 1982
  • 1981
  • 1980
  • 1979
  • 1978
  • 1977
  • 1976
  • 1975
  • 1974
  • 1973
  • 1972
  • 1971
  • 1970
  • 1969
  • 1968
  • 1967
  • 1966
  • 1965
  • 1964
  • 1963
  • 1958
  • More
Subject
News
September 25, 2026
AI Users Earn Up to 41.8% More Than Non-Users
Research conducted by economists at HSE University has revealed a significant correlation between the regular use of GenAI in the workplace and higher pay among Russian employees. The study found that individuals who frequently use GenAI in their professional activities earn notably more than those who reject these new tools or resort to them occasionally. The salary premium for highly qualified specialists reaches 41.8%. The article was published in the Voprosy Ekonomiki journal.
September 24, 2026
‘Feedback and Constructive Criticism Are Essential in Our Profession
Vincent Fardeau, Associate Professor at HSE ICEF, has reached a major career milestone: he recently published his paper ‘Asymmetric Thin Markets’ in the Journal of Financial Economics, successfully passed his major academic review, and received tenure. In this interview, Vincent discusses the story behind the paper, explains the concept of asymmetric thin markets, and shares his advice for young scholars aiming to publish in top-tier journals.
September 22, 2026
Personal Interest in Doctoral Thesis Topic Most Important for Confidence in Successful Defence
A researcher at HSE University analysed data on 1,539 doctoral students from 161 Russian universities to identify which features of a thesis topic are associated with academic success and engagement. The most important factor was found to be personal interest in the research topic, which was associated with almost all key aspects of doctoral programme experience—from engaging with the academic supervisor to research activity and confidence about successfully defending the thesis. The findings have been published in Higher Education.

 

Have you spotted a typo?
Highlight it, click Ctrl+Enter and send us a message. Thank you for your help!

Publications
  • Books
  • Articles
  • Chapters of books
  • Working papers
  • Report a publication
  • Research at HSE

?

Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction

Bioorganic and Medicinal Chemistry Letters. 2020. Vol. 30. No. 10. Article 127100.
Slesarchuk N., Khvatov E., Chistov A., Proskurin G., Nikitin T., Lazarevich A., Ulanovskaya A., Ulashchik E., Orlov A., Jegorov A., Ustinov A., Tyurin Anton P., Shmanai V., Ishmukhametov A., Korshun V. A., Osolodkin D., Kozlovskaya L., Aralov A.

Rigid amphipathic fusion inhibitors are potent broad-spectrum antivirals based on the perylene scaffold, usually decorated with a hydrophylic group linked via ethynyl or triazole. We have sequentially simplified these structures by removing sugar moiety, then converting uridine to aniline, then moving to perylenylthiophenecarboxilic acids and to perylenylcarboxylic acid. All these polyaromatic compounds, as well as antibiotic heliomycin, still showed pronounced activity against tick-borne encephalitis virus (TBEV) with limited toxicity in porcine embryo kidney (PEK) cell line. 5-(Perylen-3-yl)-2-thiophenecarboxylic acid (5a) showed the highest antiviral activity with 50% effective concentration of approx. 1.6 nM.

Research target: Basic Medicine Chemistry Biology
Language: English
Full text
DOI
Text on another site
Keywords: virusвирус КЛЕЩЕВОЙ ВИРУСНЫЙ ЭНЦЕФАЛИТTick-borne encephalitis virusпротивовирусные препаратыantiviralsRAFIantiviral activityheliomycinпротивовирусная активностьRAFIгелиомицин
Similar publications
A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand
Gureev M., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Critical dynamics of conformational exchange in a nearcritical solvent: A statistical-mechanical three-mode theory
Budkov Y., Kiselev M. G., Journal of Chemical Physics 2026 Vol. 165 No. 12 Article 124508
We develop a three-mode statistical-mechanical theory for a two-conformer solute in a near-critical solvent. A compressible lattice model with vacancies yields the Gaussian free-energy functional for a critical conserved density, an orthogonal noncritical conserved mode, and the local conformer fraction. Their couplings follow from packing and cohesive interactions, rather than being introduced phenomenologically. Kawasaki transport of the two conserved fields and ...
Added: September 24, 2026
Multilayer Membranes Based on MK-40 for Electrodialysis Separation of Ions
Yurova P., Stenina I., Yaroslavtsev A. B., Membranes and Membrane Technologies 2026 Vol. 8 No. 1 P. 1–8
In this work, the effect of applying layers of polyethyleneimines with different molecular weights (1300 and 25000 Da), polystyrene sulfonic acid or sodium polyacrylate on the surface of the heterogeneous membrane MK-40 on the selectivity to singly charged ions was investigated. It is shown that the modification leads to an increase in the selectivity coefficients P(Na+/Ca2+) and P(Li+/Mg2+), ...
Added: September 24, 2026
A28-04 Measuring the Polygenic Risk of Thrombosis May Accelerate the Detection of Chronic Thromboembolic Pulmonary Hypertension Among Other Forms of Pulmonary Hypertension
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome
Xu Y., Ryabov F., Alexandrov I. et al., USA 2026 Vol. 6 No. 8 Article 101324
Центромеры обеспечивают расхождение хромосом, однако организацию их хроматина в пределах повторяющейся альфа-сателлитной ДНК долгое время было трудно изучать. Для решения этой задачи мы создали гаплотип-разрешённые аннотации сателлитной ДНК для полной диплоидной сборки генома человека T2T-HG002. Затем с помощью метода направленного метилирования с секвенированием длинных прочтений (DiMeLo-seq) мы картировали центромерный белок A (CENP-A), модификацию H3K9me3 и ...
Added: September 23, 2026
A complete genome for the common marmoset
Hebbar P., Ryabov F., Alexandrov I. et al., Cell 2026 Vol. 189 P. 4891–4908.e12
The common marmoset is a New World monkey widely used to study primate evolution and human disease. We present a telomere-to-telomere (T2T) reference assembly for the species, plus three near-T2T haplotypes. These resolve previously inaccessible regions, including the centromeres, sex chromosomes, subterminal satellites, acrocentric chromosomes, and the major histocompatibility complex (MHC). We find marmoset centromeres ...
Added: September 23, 2026
Exact screening constraints for theories of inhomogeneous electrolytes: Generalized Stillinger–Lovett relations and a nonlinear Ward hierarchy
Budkov Y., Journal of Chemical Physics 2026 Vol. 165 No. 12 Article 124105
Exact theories of electrolyte structure must satisfy the nonlocal constraints imposed by electrostatic screening, yet these constraints are most commonly formulated only for homogeneous bulk systems and at the level of two-point correlations. Here, we develop a unified field-theoretic framework that extends them to general inhomogeneous ionic fluids and nonlinear charge correlations. Using a standard ...
Added: September 22, 2026
Formation of Singly Bonded {CpCo(CO)-η 2 -C 60 – } 2 Dimers upon the Dimerization of the CpCo(CO)-η 2 -C 60 •– Radical Anions
sobov P., Yakushev I., Shestakov A. et al., Organometallics 2025 Vol. 44 No. 24 P. 2873–2881
Interaction of {Cryptand­(K+)}­(C60•–) with CpCo­(CO)2 yields the air-sensitive crystalline salt {Cryptand­(K+)}­{CpCo­(CO)-η2-C60•–} (1), in which C60•– replaces carbonyl group in CpCo­(CO)2. Two Co–C bonds of 2.028(9) and 2.057(8)­Å are formed. The magnetic moment of 1 is 1.72 μB, indicating a doublet S = 1/2 spin state of {CpCo­(CO)-η2-C60•–} at 300 K. The compound shows a broad ...
Added: September 20, 2026
Peptide language pragmatic analysis and two-stage hierarchical learning framework for therapeutic peptide prediction
Shaitan A., Ke Y., Shutao C. et al., 2026 No. 24 Article 181
Background Therapeutic peptides exert pivotal effects in diverse biological processes, and have attracted significant interest in the field of biomedicine in recent years. However, most existing methods often fail to adequately capture the intricate interactions among amino acid residues and the contextual dependencies within peptide sequences, which hampers the extraction of deep semantic representations and ...
Added: September 18, 2026
A functional systems view on neural tracking of natural speech
Anton Rogachev, Sysoeva O., Frontiers in Systems Neuroscience 2025 Vol. 19 Article 1658243
Added: September 17, 2026
Neural tracking of natural speech in children in relation to their receptive speech abilities
Rogachev A.O., Sysoeva O. V., Cognitive Systems Research 2024 Vol. 86 Article 101236
Receptive speech is the ability to understand speech addressed to a person. It is a crucial process for a child’s cognitive development. We examine the relationship between receptive speech and neural tracking of natural speech in 52 children aged 3–8 years to infer the neurophysiological mechanisms underlying speech development. We registered a 32-channel electroencephalogram (EEG) ...
Added: September 17, 2026
Vague stimulating ideas, images and metaphors in scientific thinking: researchers' work with horizons of unclear knowledge
Poddiakov A., / Series Social Science Research Network "Social Science Research Network". 2026. No. 7437658.
Clarity of knowledge and reasoning is necessary in many cases. Yet vagueness in scientific thinking related to surprise, curiosity, "ability to engage with not-knowing" (de Freitas) and abductive reasoning is also a crucially important source of scientific creativity which supplements combinatorial logic when dealing with the already known. Starting from studies by C. S. Peirce ...
Added: September 15, 2026
Water confined in heterogeneous clay–quartz pores: Structure and dynamics from atomistic simulations
Glushak A., Tararushkin E., Smirnov G., Colloids and Surfaces A: Physicochemical and Engineering Aspects 2027 Vol. 752 Article 141756
The molecular-scale behavior of water in heterogeneous clay–quartz systems is critical for understanding cementation processes in natural soils and compacted bentonite, which is crucial for oil recovery and nuclear waste disposal barriers construction. Here we investigate how heterogeneity of mixed Na-montmorillonite and α-quartz surfaces affect water structure and dynamics in nanopores of 2.5 to 60 Å ...
Added: September 15, 2026
Coordination-driven assemblies of thioindigo and phthalocyanine chromophores: tuning optical absorption and magnetic interactions
Kolin N., Nazarov D., Krivenko K. et al., Dyes and Pigments 2026 Vol. 254 Article 113957
Interaction of thioindigo dianions with metal phthalocyanines, MPc, where M = MgII, MnII, AlIIICl and SiIVCl2, in the presence of cryptand[2.2.2] produces anionic and neutral complexes: {Crypt(K+)}2{(trans-thioindigo2−)⋅(MgIIPc)2}2−⋅2C6H4Cl2 (1); {Crypt(Cs+)}2{(trans-thioindigo2−)⋅(MnIIPc)2}2− (2), {Crypt(K+)}{(cis-Hthioindigo−)2⋅(AlIIIPc)}− (3) and {(cis-Hthioindigo−)2⋅(SiIVPc)} (4). Bidentate thioindigo2− ligand forms symmetric binuclear dimers in 1 and 2 with short M-O(thioindigo2−) bonds of 1.899(2) and 1.984(6) Å length for ...
Added: September 14, 2026
Doubly Reduced Phthalocyanine Complexes of V(IV), Cu(II), and Sn(II): Synthesis, Structure, and Spin Dynamics
Faraonov M., Romanenko N., Ivanov T. et al., Dalton Transactions 2026 Vol. 55 No. 24 P. 9428–9438
Doubly reduced phthalocyanine complexes remain largely unexplored despite their potential relevance for molecular spin-based applications. Herein, we report the synthesis of a series of crystalline complexes, {cryptand(Cs + )} 2 [M(Pc) 4– ] 2–. ...
Added: September 14, 2026
Binuclear and trinuclear 3d-metal complexes of HATNA and HAT(CN)6 with unique magnetic behavior: from extremely strong antiferromagnetic coupling to opposite sign of zero-field splitting in the same complex
Mikhailenko M., Astakhova T., Timokhina E. N. et al., Inorganic Chemistry Frontiers 2026 Vol. 13 No. 14 P. 6145–6156
series of anionic bi- and trinuclear complexes of Co II , Fe II , and Mn II with hexaazatrinaphthylene (HATNA) and hexaazatriphenylenehexacarbonitrile (HAT(CN) 6 ), incorporating paramagnetic Cp* 2 Fe + cations ( S = 1/2), were obtained and investigated. ...
Added: September 14, 2026
Host cell Z-RNAs activate ZBP1 during virus infections
Yin C., Fedorov A., Guo H. et al., Nature 2025 Vol. 648 No. 8094 P. 707–716
Herpes simplex virus 1 (HSV-1) and influenza A viruses (IAV) induce Z-form-nucleic-acid-binding protein 1 (ZBP1)-initiated cell death1,2,3,4,5,6,7,8. ZBP1 is activated by Z-RNA1,7,9, and the Z-RNAs that trigger ZBP1 during HSV-1 and IAV infections were assumed to be of viral origin1. Here, however, we show that host cell-encoded Z-RNAs are major and sufficient ZBP1-activating ligands after ...
Added: November 27, 2025
Novel 1,2,4-Triazole- and Tetrazole-Containing 4H-Thiopyrano[2,3-b]quinolines: Synthesis Based on the Thio-Michael/aza-Morita–Baylis–Hillman Tandem Reaction and Investigation of Antiviral Activity
Khramchikhin A. V., Skryl’nikova M. A., Maxim A. Gureev et al., Molecules 2023 Vol. 28 No. 21 Article 7427
A novel method for synthesizing 1,2,4-triazole- and tetrazole-containing 4H-thiopyrano[2,3-b]quinolines using a new combination of the thio-Michael and aza-Morita–Baylis–Hillman reactions was developed. Target compounds were evaluated for their cytotoxicities and antiviral activities against influenza A/Puerto Rico/8/34 virus in MDCK cells. The compounds showed low toxicity, and some exhibited moderate antiviral activity. Molecular docking identified the M2 ...
Added: January 26, 2024
The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes
Sukhorukov G., Paramonov A., Lisak O. et al., PLoS Neglected Tropical Diseases 2023 Vol. 17 No. 3 Article e0011141
Tick-borne encephalitis virus (TBEV) is a flavivirus which causes an acute or sometimes chronic infection that frequently has severe neurological consequences, and is a major public health threat in Eurasia. TBEV is genetically classified into three distinct subtypes; however, at least one group of isolates, the Baikal subtype, also referred to as "886-84-like", challenges this ...
Added: April 8, 2023
Российские регионы в пандемию COVID-19
Алов И. Н., Байдуж М. И., Goncharov R. et al., Смоленск: Универсум, 2022.
Данна книга является пионерным исследованием, описывающим распространение Covid-19 в регионах России. Коллектив авторов исследует этот феномен в глобальном (на фоне мирового опыта распространения и борьбы с пандемией), региональном и муниципальном аспектах, разбирая особенности каждой из трех волн пандемии. Для обеспечения достоверности выводов использован широкий круг статистической, нормативной, правовой и медийной информации. Результаты исследования, выполненные по гранту РФФИ ...
Added: March 16, 2023
Novel cationic meso-arylporphyrins and their antiviral activity against hsv-1
Zhdanova K. A., Savelyeva I. O., Ezhov A. V. et al., Pharmaceuticals 2021 Vol. 14 No. 3 Article 242
This work is devoted to the search for new antiherpes simplex virus type 1 (HSV-1) drugs among synthetic tetrapyrroles and to an investigation of their antiviral properties under nonphoto-dynamic conditions. In this study, novel amphiphilic 5,10,15,20-tetrakis(4-(3-pyridyl-n-propa-noyl)oxyphenyl)porphyrin tetrabromide (3a), 5,10,15,20-tetrakis(4-(6-pyridyl-n-hexanoyl)oxy-phenyl)porphyrin tetrabromide (3b) and known 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphy-rin tetraiodide (TMePyP) were synthesized, and their dark antiviral activity in vitro ...
Added: October 27, 2021
Вирус вместо пушек: как мир провожает либеральный порядок
Bordachev T., Россия в глобальной политике 2020
Мировой пандемический кризис стал долгожданным событием международной политики. Именно поэтому его политическое воздействие многократно превосходит реальную опасность коронавируса для людей. Странность происходящих событий очевидна уже для самого неподготовленного наблюдателя. Ведущие государства мира, малые и средние игроки, уже давно испытывали запрос на событие, которое позволило бы приступить к решающей стадии ревизии порядков, утвердившихся по итогам холодной ...
Added: February 8, 2021
Ramified derivatives of 5-(perylen-3-ylethynyl) uracil-1-acetic acid and their antiviral properties
Vladimir A. Korshun, RSC advances 2019 Vol. 9 No. 45 P. 26014–26023
The propargylamide of N3-Pom-protected 5-(perylen-3-ylethynyl)uracil acetic acid, a universal precursor, was used in a CuAAC click reaction for the synthesis of several derivatives, including three ramified molecules with high activities against tick-borne encephalitis virus (TBEV). Pentaerythritol-based polyazides were used for the assembly of molecules containing 2/4 antiviral 5-(perylen-3-ylethynyl) uracil scaffolds, the first examples of polyvalent perylene antivirals. Cluster compounds ...
Added: November 8, 2019
Compounds based on 5-(perylen-3-ylethynyl)uracil scaffold: High activity against tick-borne encephalitis virus and non-specific activity against enterovirus A
Vladimir A. Korshun, European Journal of Medicinal Chemistry 2019 Vol. 171 P. 93–103
Rigid amphipathic fusion inhibitors (RAFIs) are potent antivirals based on a perylene core linked with a nucleoside moiety. Sugar-free analogues of RAFIs, 5-(perylen-3-ylethynyl)uracil-1-acetic acid 1 and its amides 2, were synthesized using combined protection group strategy. Compounds 1 and 2 appeared to have low toxicity on porcine embryo kidney (PEK) or rhabdomiosarcoma (RD) cells together with remarkable activity against ...
Added: November 8, 2019
  • About
  • About
  • Key Figures & Facts
  • Sustainability at HSE University
  • Faculties & Departments
  • International Partnerships
  • Faculty & Staff
  • HSE Buildings
  • HSE University for Persons with Disabilities
  • Public Enquiries
  • Studies
  • Admissions
  • Programme Catalogue
  • Undergraduate
  • Graduate
  • Exchange Programmes
  • Summer University
  • Summer Schools
  • Semester in Moscow
  • Business Internship
  • Research
  • International Laboratories
  • Research Centres
  • Research Projects
  • Monitoring Studies
  • Conferences & Seminars
  • Academic Jobs
  • Yasin (April) International Academic Conference on Economic and Social Development
  • Media & Resources
  • Publications by staff
  • HSE Journals
  • Publishing House
  • iq.hse.ru: commentary by HSE experts
  • Library
  • Economic & Social Data Archive
  • Video
  • HSE Repository of Socio-Economic Information
  • HSE1993–2026
  • Contacts
  • Copyright
  • Privacy Policy
  • Site Map
Edit