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Crystallomycin revisited after 60 years: aspartocins B and C
MedChemComm. 2018. Vol. 9. No. 4. P. 667-675.
Vladimir A. Korshun, Prokhorenko I., Tyurin A., Shuvalov M.
The study of an archived sample of crystallomycin complex using HPLC, ESI HRMS, and 2D NMR showed
that two major components of the antibiotic, compounds 1 and 2, are lipopeptides having the same peptide
core, Asp1-cycloIJDab2-Pip3-MeAsp4-Asp5-Gly6-Asp7-Gly8-Dab9-Val10-Pro11-), N-acylated either
with Δ3-iso-tetradecenoyl or Δ3-anteiso-pentadecenoyl that are identical to aspartocins C and B, respectively.
According to the 2D NMR study, compound 2 in DMSO solution exists as a mixture of four conformers.
The producing strain was identified as Streptomyces griseorubens. Compounds 1 and 2 have considerable
Ca2+-dependent activity against Gram-positive bacteria including five MRSA strains.
Panina I., Balandin S., Tsarev A. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 2 P. 1
To date, a number of lantibiotics have been shown to use lipid II — a highly conserved peptidoglycan precursor in the cytoplasmic membrane of bacteria — as their molecular target. The α-component (Lchα) of the two-component lantibiotic lichenicidin (Lchα), previously isolated from the Bacillus licheniformis VK21 strain, seems to contain two putative lipid II binding ...
Added: February 21, 2023
Lohan S., Konshina A. G., Efremov R. et al., Journal of Medicinal Chemistry 2023 Vol. 66 No. 1 P. 855-874
A series of small (7- to 12-mer) amphipathic cationic peptides were designed and synthesized with the ultimate goal of creating a set of short helical peptides with broad-range bactericidal activity and good selectivity toward the bacterial cells. Activity analysis identified a lead 12-mer peptide 8b with broad spectrum activity against Gram-positive (MIC=3.1-6.2 µg/mL) and Gram-negative ...
Added: February 21, 2023
Panina I. S., Chugunov A., Efremov R., Russian Journal of Bioorganic Chemistry 2018 Vol. 44 No. 6 P. 653-664
The growing problem of antibiotic resistance in medicine raises the attention to antimicrobial substances that act on non-protein molecules, which have more conservative structure comparing to proteins or peptides. One of the most promising and studied targets is lipid II — the participant of the bacterial cell wall biosynthetic pathway. Lipid II is present in ...
Added: February 25, 2019
Shakhmatov E., Toukach Ph., Makarova E., Carbohydrate Polymers 2020 Vol. 235 Article 115978
The polysaccharide PGO containing 76% of uronic acids, was obtained from peels and membranes of Punica granatum fruits by extraction to the aqueous solution of (NH4)2C2O4. The chemical structure of PGO was characterized by enzymatic and partial acid hydrolyses, Smith degradation and 1D/2D NMR spectroscopy. It has been found that PGO consisted mainly of highly ...
Added: October 14, 2021
Пенза : Пензенский государственный университет, 2016
Рассматриваются актуальные проблемы теории и практики повышения надежности и качества; эффективности внедрения инновационных и информационных технологий в фундаментальных научных и прикладных исследованиях, образовательных и коммуникативных системах и средах, экономике и юриспруденции; методов и средств анализа и прогнозирования показателей надежности и качества приборов, устройств и систем, а также анализа непараметрических моделей и оценки остаточного ресурса изделий ...
Added: October 29, 2022
М. : Энциклопедия, Инфра-М, 2017
The New Russian Encyclopedia is a fundamental reference publication in 18 volumes that characterizes nature, population, economy, history, science, art, technology and other important aspects. Contains about 60,000 articles, about 30,000 biographies, about 15,000 color illustrations, maps, charts, diagrams, tables. Leaves since 2003. ...
Added: October 29, 2018
Автономная некоммерческая организация «Национальный научно-образовательный центр «Большая российская энциклопедия» (АНО БРЭ), 2022
Основными задачами Портала являются создание и поддержание в актуальном состоянии электронной национальной базы знаний на русском языке, консолидирующей сведения об окружающем мире, предназначенной для широкого круга пользователей, а также популяризация науки, трансфер научных результатов в образование, культура использования данных и научные междисциплинарные коммуникации. Важнейшая социальная функция Портала — доступность правдивой научной информации и формирование доверия пользователя к ней.
Контент портала
Основу контента составляют дополненные и расширенные статьи «Большой ...
Added: September 12, 2022
Olloqui-Sariego J. L., Zakharova G., Poloznikov A. et al., Electrochimica Acta 2020 Vol. 351 P. 136465
A major challenge in the design of electrochemical biodevices is to achieve fast rates of electron exchange between proteins and electrodes. In this work, we show that a significant increase in the direct electron transfer rate between a graphite electrode and Tobacco Peroxidase takes place when a surface exposed leucine, located in the vicinity of ...
Added: July 22, 2020
Lohan S., Mandal D., Choi W. et al., Journal of Medicinal Chemistry 2022 Vol. 65 No. 1 P. 665-687
We report the synthesis and antibacterial activities of a series of amphiphilic membrane-active peptides composed, in part, of various non-genetically coded hydrophobic amino acids. Lead cyclic peptides, 8C and 9C, showed broad-spectrum activity against drug-resistant Gram-positive (MIC=1.5-6.2 µg/mL) and Gram-negative (MIC=12.5-25 µg/mL) bacteria. Cytotoxicity study showed the predominant lethal action of the peptides against bacteria ...
Added: February 1, 2022
М. : Энциклопедия, Инфра-М, 2018
The New Russian Encyclopedia is a fundamental reference publication in 18 volumes that characterizes nature, population, economy, history, science, art, technology and other important aspects. Contains about 60,000 articles, about 30,000 biographies, about 15,000 color illustrations, maps, charts, diagrams, tables. Leaves since 2003. ...
Added: October 26, 2018
Goncharuk M., Baleeva N., Nolde Dmitry E. et al., Communications Biology 2022 Vol. 5 Article 706
“Fluorescence-Activating and absorption-Shifting Tag” (FAST) is a well-studied fluorogenactivating
protein with high brightness and low size, able to activate a wide range of
fluorogens. This makes FAST a promising target for both protein and fluorogen optimization.
Here, we describe the structure-based rational design of the enhanced FAST mutants,
optimized for the N871b fluorogen. Using the spatial structure of the ...
Added: August 1, 2022
Bocharov E. V., Gremer L., Urban A. S. et al., Journal of Medicinal Chemistry 2021 Vol. 64 No. 22 P. 16464-16479
Alzheimer’s disease (AD) is a severe neurodegenerative pathology with
no effective treatment known. Toxic amyloid-β peptide (Aβ) oligomers play a crucial
role in AD pathogenesis. All-D-Enantiomeric peptide D3 and its derivatives were
developed to disassemble and destroy cytotoxic Aβ aggregates. One of the D3-like
compounds is approaching phase II clinical trials; however, high-resolution details of its
disease-preventing or pharmacological actions ...
Added: February 1, 2022
Complex approach for analysis of snake venom α-neurotoxins binding to HAP, the high-affinity peptide
Kudryavtsev D., Tabakmakher V., Budylin Gleb S. et al., Scientific Reports 2020 Vol. 10 Article 3861
Snake venom α-neurotoxins, invaluable pharmacological tools, bind with high affinity to distinct subtypes of nicotinic acetylcholine receptor. The combinatorial high-affinity peptide (HAP), homologous to the C-loop of α1 and α7 nAChR subunits, binds biotinylated α-bungarotoxin (αBgt) with nanomolar affinity and might be a protection against snake-bites. Since there are no data on HAP interaction with other ...
Added: May 14, 2020
Galitskaya E., Privalov A., Vogel M. et al., Journal of Chemical Physics 2021 Vol. 154 No. 3 Article 034904
The Field Cycling (FC) 2H NMR relaxometry was applied to study dynamics in Nafion NR 212 in the temperature range from 300K to 190K and water content l=8.2. The sensitive time window of FC was extended up to 8 decades using temperature-frequency superposition principle and master curve. The rotational correlation times obtained from 2H FC ...
Added: September 16, 2022
М. : Энциклопедия, Инфра-М, 2017
The New Russian Encyclopedia is a fundamental reference publication in 18 volumes that characterizes nature, population, economy, history, science, art, technology and other important aspects. Contains about 60,000 articles, about 30,000 biographies, about 15,000 color illustrations, maps, charts, diagrams, tables. Leaves since 2003. ...
Added: October 29, 2018
М. : Энциклопедия, Инфра-М, 2018
The New Russian Encyclopedia is a fundamental reference publication in 18 volumes that characterizes nature, population, economy, history, science, art, technology and other important aspects. Contains about 60,000 articles, about 30,000 biographies, about 15,000 color illustrations, maps, charts, diagrams, tables. Leaves since 2003. ...
Added: October 28, 2018
Galitskaya E., Privalov A., Weigler M. et al., Journal of Membrane Science 2020 Vol. 596 Article 117691
It is established that the values of the coefficients of self-diffusion of water in proton-exchange membranes at a fixed temperature and the amount of moisture content depend on the method of membrane manufacture, the length of the side chain (diameter of channels), but within the experimental error do not depend on the thickness of the ...
Added: October 12, 2022
М. : Энциклопедия, Инфра-М, 2017
The New Russian Encyclopedia is a fundamental reference publication in 18 volumes that characterizes nature, population, economy, history, science, art, technology and other important aspects. Contains about 60,000 articles, about 30,000 biographies, about 15,000 color illustrations, maps, charts, diagrams, tables. Leaves since 2003. ...
Added: October 31, 2018
Vladimir A. Korshun, Amino Acids 2018 Vol. 50 No. 12 P. 1697-1705
4-Chloro-l-kynurenine (3-(4-chloroanthraniloyl)-l-alanine, l-4-ClKyn), an amino acid known as a prospective antidepressant, was recently for the first time found in nature in the lipopeptide antibiotic taromycin. Here, we report another instance of its identification in a natural product: 4-chloro-l-kynurenine was isolated from acidic hydrolysis of a new complex peptide antibiotic INA-5812. l-4-ClKyn is a fluorescent compound responsible for the ...
Added: November 8, 2019
Долгопрудный : МФТИ, 2021
Труды 63-й Всероссийской научной конференции МФТИ. Включены результаты оригинальных исследований студентов, аспирантов, преподавателей и научных сотрудников МФТИ и дружественных учебных и научных организаций. Статьи представляют интерес для специалистов, работающих в области радиотехники и компьютерных технологий ...
Added: October 29, 2021
Фонд им. В.И. Вернадского, 2022
В сборнике студенческих и аспирантских работ стипендиатов Неправительственного экологического фонда имени В.И. Вернадского 2021–2022 года представлены статьи, отражающие промежуточные научные исследования стипендиатов, проводимые как самостоятельно, так и в составе научных коллективов, а также итоги исследований, опыта, описание идей, сделанных в ходе выполнения проектов в рамках масштабной годовой Стипендиальной программы. Тематика исследований, представленных в сборнике, является весьма разносторонней, но все работы посвящены актуальным ...
Added: May 13, 2023
Vladimir A. Korshun, Journal of Organic Chemistry 2017 Vol. 82 No. 19 P. 10015-10024
Oligonucleotide probes labeled with pyrene pairs that form excimers have a number of applications in hybridization analysis of nucleic acids. A long excited state lifetime, large Stokes shift, and chemical stability make pyrene excimer
an attractive fluorescent label. Here we report synthesis of chiral phosphoramidite building blocks based on (R)-4- amino-2,2-dimethylbutane-1,3-diol, easily available from an inexpensive D-(−)-pantolactone. ...
Added: November 8, 2019
Can Modern Molecular Modeling Methods Help Find the Area of Potential Vulnerability of Flaviviruses?
Shanshin D., Borisevich S., Bondar A. et al., International Journal of Molecular Sciences 2022 Vol. 23 No. 14 Article 7721
Flaviviruses are single-stranded RNA viruses that have emerged in recent decades and infect up to 400 million people annually, causing a variety of potentially severe pathophysiological processes including hepatitis, encephalitis, hemorrhagic fever, tissues and capillaries damage. The Flaviviridae family is represented by four genera comprising 89 known virus species. There are no effective therapies available ...
Added: February 8, 2024
Тверь : ТвГУ, 2014
Труды региональных научных проектов Тверской области 2014 г. в области фундаментальных исследований ...
Added: March 7, 2020