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July 13, 2026
Biologists Discover Unique Properties of MiR-93-5p MicroRNA in Prostate Cancer
Researchers at the International Laboratory of Microphysiological Systems of the HSE Faculty of Biology and Biotechnology investigated how different isoforms of the same microRNA influence gene function in prostate adenocarcinoma. The study found that in some cases, microRNAs can reinforce each other’s effects by targeting and suppressing the same genes. This finding offers a fresh perspective on the molecular mechanisms underlying tumour development and on the search for disease biomarkers. The results have been published in PeerJ.
July 13, 2026
'My Goal Is to Become a Tenured Professor'
Mikhail Samatov focuses on the theoretical study of perovskite solar cells. In this interview for the HSE Young Scientists project, he talks about working on HSE University’s supercomputer, collaborating with Peking University, and making furniture.
July 9, 2026
HSE Economists Use Search Queries to Forecast Birth Rates
Researchers from the HSE Faculty of Economic Sciences have shown that the accuracy of birth rate forecasts for Russia can be improved by almost 50% by incorporating the dynamics of online search queries related to pregnancy and childbirth into forecasting models. In the best-performing models, the forecasting error fell from 4.6% to 3.2%. The findings have been published in Populations and Economics.

 

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Разработка параллельных генетических алгоритмов вещественного кодирования для систем поддержки принятия решений социально-экономического и экологического планирования

Бизнес-информатика. 2019. Т. 13. № 1. С. 33–44.
Akopov A. S., Beklaryan A., Thakur M., Dev Verma B.

This article presents a new approach to designing decision-making systems for socio-economic and ecological planning using parallel real-coded genetic algorithms (RCGAs), aggregated with simulation models by objective functions. A feature of this approach is the use of special agent-processes, which are autonomous genetic algorithms (GAs) acting synchronously in parallel streams and exchanging periodically by the best potential decisions. This allows us to overcome the premature convergence problem in local extremums. In addition, it was shown that the combined use of different crossover and mutation operators significantly improves the time efficiency of RCGAs, as well as the quality of the decisions obtained (proximity to optimum), providing a more diverse population of potential decisions (individuals). In this paper, several suggested crossover and mutation operators are used, in particular, a modified simulated binary crossover (MSBX) and scalable uniform mutation operator (SUM), which is based on quantization of the feasible region of the search space (dividing the feasible region on small subranges with equal lengths) while taking into account the common amount of interacting agent-processes and the maximum number of internal iterations of GAs forming potential decisions through selection, crossover and mutation. Such a functional dependence of the parameters of heuristic operators on the corresponding process characteristics, aggregated with the combined probabilistic use of various crossover and mutation operators, makes it possible to get maximum effect from the multi-processes architecture. As a result, the computational possibilities of RCGAs for solving large-scale optimization problems (hundreds and thousands of decision variables, multiple objective functions) become dependent only on the physical characteristics of the existing computing clusters. This makes it possible to efficiently use supercomputer technologies. An important advantage of the proposed system is the implemented integration between the developed parallel RCGA (implemented in C++ and MPI) and the simulation modelling system AnyLogic (Java) using JNI technology. Such an approach allows one to synthesize real world optimization problems in decision-making systems of socio-economic and ecological planning, using simulation methods supported by AnyLogic. The result is an effective solution to singleobjective and multi-objective optimization tasks of large dimension, in which the objective functionals are the result of simulation modeling and cannot be obtained analytically.

Research target: Computer Science Mathematics
Priority areas: IT and mathematics business informatics
Language: Russian
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Keywords: имитационное моделированиеAnyLogicмногоцелевая оптимизацияsimulation modelingmulti-objective optimizationAnyLogicPareto frontфронт ПаретоReal-coded genetic algorithmsгенетический алгоритм вещественного кодирования
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