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On consolidated predictive model of the natural history of breast cancer considering primary tumour and distant metastases growth
P. S106–S106.
Ella Y Tyuryumina, Neznanov A.
PRIMARY THERAPY OF EARLY BREAST CANCER
Evidence, Controversies, Consensus
15th St.Gallen International Breast Cancer Conference
Vienna, Austria, 15–18 March 2017
Бодунова Н. А., Хатьков И. Е., Найговзина Н. Б. et al., Вестник Всероссийского общества специалистов по медико-социальной экспертизе, реабилитации и реабилитационной индустрии 2026 Т. 22 № 1 С. 109–122
Introduction. The increasing incidence and mortality of cancer, along with the growing contribution of hereditary malignancies, necessitate the implementation of personalized prevention models based on molecular genetic risk stratification and early cancer detection among asymptomatic carriers of highly penetrant germline mutations. Aim. The aim of this study was to evaluate the clinical and economic effectiveness ...
Added: April 22, 2026
Bhangdia K., May M. L., Kocarnik J. M. et al., The Lancet Oncology 2026 Vol. 27 No. 3 P. 302–326
Background
Breast cancer is a leading cause of mortality and morbidity among females worldwide. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023, we provided an updated comprehensive assessment of the epidemiological trends, disease burden, and risk factors associated with breast cancer globally, regionally, and nationally from 1990 to 2023.
Methods
Breast ...
Added: March 6, 2026
Silkina M., Razumovskaya A., Timur Kulagin et al., Biochimie 2025 Vol. 234 P. 48–61
Breast cancer remains a major challenge and new therapeutic approaches are needed for its treatment. Ferroptosis is considered a promising alternative cell death mechanism to eliminate resistant cancer cells. In previous works, we identified that lower IGFBP6 gene expression in tumor tissue corresponds to a worse prognosis for breast cancer patients and, at the same, time makes ...
Added: April 9, 2025
Касьянов Е. Д., Пинахина Д. В., Ракитько А.С. et al., Журнал неврологии и психиатрии им. С.С. Корсакова 2023 Т. 123 № 4-2 С. 65–73
Цель исследования. Провести разведочный Менделевский рандомизационный анализ причинных связей ангедонии с широким кругом психиатрических и соматических фенотипов на основе генетических данных участников популяционного исследования. ...
Added: March 4, 2025
Razumovskaya A., Кулагин Т. А., Fatkulin A. et al., Биотехнология 2024 Т. 40 № 6 С. 74–83
To date, breast cancer is the most common oncological pathology among the female population both in Russia and worldwide. Previously, our laboratory team identified a significant prognostic marker for breast cancer, namely the ELOVL5 gene, the expression level of which in couple with the IGFBP6 gene allowed to predict the probability of breast cancer recurrence ...
Added: November 11, 2024
Shkurnikov M., Darya Averinskaya, Stekolshchikova E. et al., Biochimie 2024 Vol. 227 P. 77–85
Breast cancer recurrence is associated with the growth of disseminated cancer cells that separate from the primary tumor before surgical treatment and hormonal therapy and form a metastatic niche in distant organs. We previously demonstrated that IGFBP6 expression is associated with the risk of early relapse of luminal breast cancer. Knockdown of IGFBP6 in MDA-MB-231 breast cancer ...
Added: August 14, 2024
Мельник Ю. В., Отечественная и зарубежная педагогика 2023 Т. 1 № 2 (91) С. 153–168
Introduction. The social and pedagogical inclusion of learners is the result of the combinatorial impact of various factor determinants that affect both the content of the educational process itself and the interactive network of exceptional individual’s social contacts in his / her interaction with various groups of subjects of teaching and educational activities. A special ...
Added: March 14, 2024
Rusina P., Gandalipov E., Abdyusheva Y. et al., Cancers 2023 Vol. 15 No. 15 Article 3766
General toxicity for the organism is a major drawback of anticancer drugs. Development of new generation chemotherapeutics requires the knowledge about macromolecules critical for tumor cell viability. Among these species (called therapeutic targets), the protein kinases are the established enzymes. However, the parts of protein kinases that are supposed to be targeted by drugs can ...
Added: November 1, 2023
Nikulin S., Razumovskaya A., Poloznikov A. et al., Frontiers in Molecular Biosciences 2023 Vol. 10 Article 1075704
Relapse of breast cancer is one of the key obstacles to successful treatment. Previously we have shown that low expression of ELOVL5 and IGFBP6 genes in breast cancer tissue corresponded to poor prognosis. ELOVL5 participates directly in the elongation of polyunsaturated fatty acids (PUFAs) that are considered to play an important role in cancer cell metabolism. Thus, in this work we ...
Added: February 22, 2023
Nersisyan S., Zhiyanov A., Еngibaryan N. et al., Frontiers in Genetics 2022 Vol. 13 Article 1070528
A widely used procedure for selecting significant miRNA-mRNA or isomiR-mRNA pairs out of predicted interactions involves calculating the correlation between expression levels of miRNAs/isomiRs and mRNAs in a series of samples. In this manuscript, we aimed to assess the validity of this procedure by comparing isomiR-mRNA correlation profiles in sets of sequence-based predicted target mRNAs ...
Added: December 1, 2022
Berdysheva E., , in: The Ambivalence of Power in the Twenty-First Century Economy: Cases from Russia and beyond.: L.: UCL Press, 2022. Ch. 13 P. 261–279.
Russian cancer policy is being shaped in line with the militaristic metaphor of pharmacological war against cancer with the drug-bullets that are produced in Russia. This study examines the role of meaning making (definitional) power in the arrangement of political choice with regard to this policy. It is aimed at demonstrating that in contrast to ...
Added: October 31, 2022
Beniaminov A., Grigory A. Puzanov, Krasnov G. et al., Frontiers in Genetics 2018 Vol. 9 No. 169
Hypermethylation of promoter CpG islands is generally recognized epigenetic mechanism responsible for gene silencing in cancer. However, molecular details on how this epigenetic mark triggers the process of gene downregulation are still elusive. Here, we used deep bisulfite sequencing and qPCR analysis to investigate the pattern of CpG methylation of ALDH1L1 promoter region and its association with ...
Added: October 11, 2022
Shigapova L., Chudakova D., Gordiev M. et al., Frontiers in Oncology 2018 Vol. 8
The Russian population consists of more than 100 ethnic groups, presenting a unique opportunity for the identification of hereditary pathogenic mutations. To gain insight into the landscape of heredity pathogenic variants, we employed targeted next-generation sequencing to analyze the germline mutation load in the DNA damage response and repair genes of hereditary breast and ovary ...
Added: June 20, 2022
Nikitin A., Chudakova D., Enikeev R. et al., Frontiers in Oncology 2020 Vol. 10 Article 666
Genome instability—the increased tendency of acquiring mutations in the genome and ability of a cell to tolerate high mutation burden—is one of the drivers of cancer. Genome instability results from many causes including defects in DNA repair systems. Previously, it has been shown that germline pathogenic mutations in DNA Mismatch Repair (MMR) pathway cause cancer-predisposing ...
Added: June 20, 2022
Kirillova A., Kovalskaya E., Brovkina Olga et al., Journal of Assisted Reproduction and Genetics 2020 Vol. 37 No. 4 P. 905–911
With the increased rate of stable remission after gonadotoxic cancer treatment, new methods of fertility preservation are required in order to provide the best possible care for oncological patients. Here, we report an original case of euploid blastocyst cryopreservation after in vitro maturation of ovarian tissue oocytes (OTO IVM). Thirty-three oocytes were obtained from the ...
Added: June 20, 2022
Arnold S., Cortland J., Maltseva D. et al., Journal of Cancer Research and Clinical Oncology 2021 Vol. 148 No. 6 P. 1525–1542
Purpose:
The transcription factor Fra-2 affects the invasive potential of breast cancer cells by dysregulating adhesion molecules in vitro. Previous results suggested that it upregulates the expression of E- and P-selectin ligands. Such selectin ligands are important members of the leukocyte adhesion cascade, which govern the adhesion and transmigration of cancer cells into the stroma of ...
Added: October 23, 2021