• A
  • A
  • A
  • АБВ
  • АБВ
  • АБВ
  • A
  • A
  • A
  • A
  • A
Обычная версия сайта
  • RU
  • EN
  • HSE University
  • Publications
  • Articles
  • Первый дженерик тирзепатида GP30931: физико-химическое и биологическое сходство с референтным лекарственным средством
  • RU
  • EN
Расширенный поиск
Высшая школа экономики
Национальный исследовательский университет
Priority areas
  • business informatics
  • economics
  • engineering science
  • humanitarian
  • IT and mathematics
  • law
  • management
  • mathematics
  • sociology
  • state and public administration
by year
  • 2028
  • 2027
  • 2026
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007
  • 2006
  • 2005
  • 2004
  • 2003
  • 2002
  • 2001
  • 2000
  • 1999
  • 1998
  • 1997
  • 1996
  • 1995
  • 1994
  • 1993
  • 1992
  • 1991
  • 1990
  • 1989
  • 1988
  • 1987
  • 1986
  • 1985
  • 1984
  • 1983
  • 1982
  • 1981
  • 1980
  • 1979
  • 1978
  • 1977
  • 1976
  • 1975
  • 1974
  • 1973
  • 1972
  • 1971
  • 1970
  • 1969
  • 1968
  • 1967
  • 1966
  • 1965
  • 1964
  • 1963
  • 1958
  • More
Subject
News
September 11, 2026
How to Assess Students Knowledge in the Age of AI
A researcher at HSE University has proposed a flowchart to help lecturers decide how to assess students who use artificial intelligence. It shows where the use of AI should be restricted and where it can be incorporated into the learning process. The article has been published in IT Professional.
September 9, 2026
‘Balkan Hospitality Opens Doors: Studying Dialects on the Verge of Extinction
You cannot study spoken dialects from books. Instead, you need to go to a village, seek out its elders, and earn the trust of local residents before you can record hours of spontaneous stories. This is how Natalia Muravleva, Associate Professor at the Faculty of Humanities, conducts her research. Her internship in Serbia continued her long-standing study of dialects spoken by Macedonian settlers. In this interview, she discusses how diaspora cultural centres help researchers reach informants, why native speakers need to be interviewed only in their own language (otherwise, as she puts it, they may 'break'), and how a single field season helped her finalise her monograph. She also shares warm memories of autumn in Belgrade and of colleagues with whom grammar can be discussed in three languages at once.
September 9, 2026
Scientists Train Neural Network to Generate Process Plans from 3D Models
Researchers at the HSE FCS AI and Digital Science Institute have developed CAD2TechSpec, a framework that converts 3D models of mechanical parts into machining process plans—step-by-step instructions for machine tools. The solution aims to reduce the time required for the design and preparation of technical process documentation in mechanical engineering, aircraft manufacturing, and other high-tech industries. The study findings have been published in PeerJ Computer Science.

 

Have you spotted a typo?
Highlight it, click Ctrl+Enter and send us a message. Thank you for your help!

Publications
  • Books
  • Articles
  • Chapters of books
  • Working papers
  • Report a publication
  • Research at HSE

?

Первый дженерик тирзепатида GP30931: физико-химическое и биологическое сходство с референтным лекарственным средством

Разработка и регистрация лекарственных средств. 2025. Т. 14. № 2. С. 54–74.
Луговик И. А., Бабина А. В., Арутюнян С. С., Ермолаева Д. О., Сапарова В. Б., Кобелева Т. Н., Заикин П. Г., Микушина А. Д., Букатин А. С., Eliseev I., Зайчик Б. Ц., Керученько Я. К., Охрименко И. С., Бочаров Э. В., Тальдаев А. Х., Лушпа В. А., Макаренко И. Е., Драй Р. В.
Research target: Biology Clinical Medicine
Language: Russian
DOI
Text on another site
Keywords: производство дженериковNMRрекомбинантные белкипептидФизико-химические методы анализаgenericrecombinant peptideGIPtirzepatideGLP-1physicochemical characterizationтирзепатид
Publication based on the results of:
Molecular evolution, protein motions and computational molecular modeling (2024)
Similar publications
Разработка методик на основе айтрекинга для диагностики когнитивных функций у детей
Ребрейкина А. Б., Liaukovich K., Современная зарубежная психология 2024 Т. 13 № 2 С. 33–43
Создание методик диагностики на основе анализа движений глаз является особенно актуальным для оценки когнитивных функций у детей, которые не могут дать речевой или моторный ответ в силу своего возраста или из-за нарушений развития. Для таких детей использование объективных методов оценки когнитивных функций на основе айтрекинга может стать полезным диагностическим инструментом, дополняющим традиционные поведенческие опросники и ...
Added: September 8, 2026
Развитие когнитивных функций детей с помощью методик, использующих видеоокулографию
Ребрейкина А. Б., Liaukovich K., Современная зарубежная психология 2023 Т. 12 № 4 С. 51–61
Активное развитие метода видеоокулографии, т. е. регистрации движений глаз, создает возможности для создания новых подходов для развития когнитивных функций и обучения. Методики, основанные на видеоокулографии, могут быть полезны не только для детей с серьезными нарушениями моторных функций, но и детей с нарушениями развития когнитивных функций, прежде всего внимания, так как контроль движений глаз тесно связан ...
Added: September 8, 2026
Вегетативные и поведенческие показатели при увеличении когнитивной нагрузки у здоровых добровольцев
Портнова Г. В., Liaukovich K., Васильева Л. Н. et al., Журнал высшей нервной деятельности им. И.П. Павлова 2022 Т. 72 № 4 С. 504–519
Когнитивная и эмоциональная нагрузка в ходе увеличения сложности задач приводит к активации различных звеньев вегетативной нервной системы и может сопровождаться как увеличением эффективности решения задач, так и способствовать дестабилизации эмоционального состояния и уменьшению продуктивности. Увеличение когнитивной нагрузки при условии высокой мотивации испытуемых является стрессовым фактором и выражается в различной реакции симпатического и парасимпатического звеньев в ...
Added: September 8, 2026
DSCA-HLAII: A dual-stream cross-attention model for predicting peptide–HLA class II interaction and presentation
Shaitan A., Ke Y., Hongjun Y. et al., PLoS Computational Biology 2026 Article e1013836
The interaction between peptides and human leukocyte antigen class II (HLA-II) molecules plays a pivotal role in adaptive immune responses, as HLA-II mediates the recognition of exogenous antigens and initiates T cell activation through peptide presentation. Accurate prediction of peptide-HLA-II binding serves as a cornerstone for deciphering cellular immune responses, and is essential for guiding the optimization of antibody therapeutics. ...
Added: September 7, 2026
Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder
Proskurnina E., Liaukovich K., Bychkovskaya L. et al., Metabolites 2023 Vol. 13 No. 1 P. 73
Added: September 7, 2026
Event-Related Potential Study of Recovery of Consciousness during Forced Awakening from Slow-Wave Sleep and Rapid Eye Movement Sleep
Liaukovich K., Sazhin S., Bobrov P. et al., International Journal of Molecular Sciences 2022 Vol. 23 No. 19 P. 11785
Added: September 7, 2026
Implicit auditory perception of local and global irregularities in passive listening condition
Liaukovich K., Ukraintseva Y., Martynova O., Neuropsychologia 2022 Vol. 165 P. 108129
Added: September 7, 2026
Pupillometry and autonomic nervous system responses to cognitive load and false feedback: an unsupervised machine learning approach
Alshanskaia E., Portnova G., Liaukovich K. et al., Frontiers in Neuroscience 2024 Vol. 18
Added: September 7, 2026
Characteristics of the Frequency-Following Response to Changes in the Acoustic Parameters of a Speech Signal (Isolated Syllable)
Oknina L. B., Podlepich V. V., Sieber I. et al., Human Physiology 2026 Vol. 52 No. 3 P. 295–301
The aim of this study was to evaluate the potential use of the frequency-following response (FFR) for assessing preserved perception of simple speech stimuli in humans. To this end, event-related potentials (ERPs) elicited by isolated Russian syllables were recorded and analyzed in 29 healthy subjects in two frequency ranges, the standard range (1—40 Hz) and ...
Added: September 6, 2026
Что такое Свобода? Свобода воли, свободы личности, конституционная модель и законодательное регулирование
Момджян К. Х., Кржевов В. С., Poddiakov A. et al., М.: Новые печатные технологии, 2025.
При всей кажущейся ясности и недвусмысленности понятия «свобода» дать ему исчерпывающую научную дефиницию весьма затруднительно. У каждой отрасли знания свой подход к трактовке этого многоаспектного понятия. В ходе обсуждения, материалы которого вошли в настоящий сборник, свобода рассматривается с позиций философии, социологии, юриспруденции, психологии, нейрофизиологии и т.д. Участники дискуссии рассуждают о границах свободы воли и субъектности человека, о соотношении свободы и ...
Added: September 6, 2026
Event-related potentials and presaccadic activity in response to affective stimuli in participants with obsessive-compulsive disorder
Liaukovich K., Panfilova E., Khayrullina G. et al., International Journal of Psychophysiology 2025 Vol. 207 P. 112475
Added: September 5, 2026
The acoustic features of sincere joyful, sad, and fearful human non-verbal vocalizations and its effect on the emotional valence of cat’s meowing
Portnova G., Liaukovich K., Sharaev M., Cognitive Neurodynamics 2025 Vol. 19 Article 181
Added: September 5, 2026
Validation of the obsessive–compulsive disorder-triggering image set (OCD-TIS)
Liaukovich K., Bainbridge E., Khayrullina G. et al., Neuroscience and Behavioral Physiology 2026 Vol. 56 P. 10–19
Added: September 5, 2026
Commentary: Deep learning in obsessive-compulsive disorder: a narrative review
Kashevarova O., Portnova G., Khayrullina G. et al., Frontiers in Psychiatry 2026 Vol. 17 P. 1776019
Added: September 5, 2026
Does Sound Timing Organization Matter? How Time Interval Influences the Perception of Closely Spaced Frequencies
Liaukovich K., Martynova O., Brain Sciences 2026 Vol. 5 No. 16 P. 439
Highlights What are the main findings? Temporal predictability may enhance auditory frequency discrimination, but only under active listening and when discrimination is difficult; the local irregularity (five-tone bundles) yields higher hit rates and perceptual sensitivity (d’) compared to oddball or two-tone paradigms, accompanied by enhanced P300 amplitude. Participants may show a dissociation between objective performance and subjective awareness: ...
Added: September 4, 2026
Прогностическое значение полигенного профиля риска при дилатационной кардиомиопатии: анализ краткосрочной выживаемости
Волчкова Е. А., Легкова К. С., Минушкина Л. О. et al., Российский кардиологический журнал 2026 Т. 31 № 8S Статья 6987
Goal. To assess the contribution of polygenic risk scores to the short‑term mortality prediction model in patients with dilated cardiomyopathy (DCM). Materials and methods. The study included 137 patients with DCM. The mean age was 56.8 ± 13.5 years; there were 115 men (83.9 %). The median follow‑up period was 17 [13; 22] months. During the follow‑up period, 26 ...
Added: August 24, 2026
From data to knowledge: artificial intelligence methods for studying comorbidity in electronic health records
Лукьяненко Д. В., Ragimova A., Мухорина А. et al., European Physical Journal: Special Topics 2026 P. 1–24
Electronic health records (EHRs) contain vast volumes of clinical information that encode complex relationships between diseases. Traditional approaches to the analysis of interrelated or co-occurring diseases have focused on pairwise associations between diagnoses, missing the higher-order structures that characterise multimorbid patients. The present paper offers a narrative review of existing statistical, machine-learning, and artificial intelligence ...
Added: August 20, 2026
Diverse Interactions of Sterols with Amyloid Precursor Protein Transmembrane Domain Can Shift Distribution Between Alternative Amyloid-β Production Cascades in Manner Dependent on Local Lipid Environment
Volynsky P., Urban A., Pavlov K. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 2 Article 553
Alzheimer’s disease (AD) pathogenesis is correlated with the membrane content of various lipid species, including cholesterol, whose interactions with amyloid precursor protein (APP) have been extensively explored. Amyloid-β peptides triggering AD are products of APP cleavage by secretases, which differ depending on the APP and secretase location relative to ordered or disordered membrane microdomains. We used high-resolution NMR to probe ...
Added: October 12, 2025
Magnetic Resonance-Based Analytical Tools to Study Polyvinylpyrrolidone–Hydroxyapatite Composites
Petrova A., Mamin G., Gnezdilov O. et al., Polymers 2023 Vol. 15 No. 22 P. 4445–4460
The synthesis of biocompatible and bioresorbable composite materials, such as a “polymer matrix-mineral constituent,” stimulating the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine and materials science. Composite films of bioresorbable polymer of polyvinylpyrrolidone (PVP) and hydroxyapatite (HA) were obtained. ...
Added: August 13, 2025
Structural Basis of Activity of HER2-Targeting Construct Composed of DARPin G3 and Albumin-Binding Domains
Konshina A., Bocharov E., Konovalova E. et al., International Journal of Molecular Sciences (Швейцария) 2024 Vol. 25 No. 21 Article 11370
Non-immunoglobulin-based scaffold proteins (SPs) represent one of the key therapeutic target-specific and high-affinity binders in modern medicine. Among their cellular targets are signaling receptors, in particular, receptor tyrosine kinases, whose dysfunction leads to the development of cancer and other serious diseases. Successful applications of SPs have been reported for HER receptor type 2 (HER2), a member of the human ...
Added: December 9, 2024
Structural Analysis and Activity Correlation of Amphiphilic Cyclic Antimicrobial Peptides Derived from the [W4R4] Scaffold
El-Mowafi S. A., Konshina A. G., Mohammed E. H. et al., Molecules 2023 Vol. 28 No. 24 Article 8049
In our ongoing quest to design effective antimicrobial peptides (AMPs), this study aimed to elucidate the mechanisms governing cyclic amphiphilic AMPs and their interactions with membranes. The objective was to discern the nature of these interactions and understand how peptide sequence and structure influence antimicrobial activity. We introduced modifications into the established cyclic AMP peptide, ...
Added: September 15, 2024
Inherent surface superconducting phase in the Mo8Ga41 single-gap bulk superconductor as seen by nuclear resonance and tunneling spectroscopy
Gippius A. A., Gunbin A. V., Tkachev A. V. et al., Intermetallics 2023 Vol. 163 Article 108063
A comprehensive study of the intermetallic superconductor Mo8Ga41 was conducted by means of HRPXRD, abinitio calculations, NMR and NQR spectroscopy on 69Ga and 71Ga nuclei, as well as tunneling spectroscopy. All experimental methods used demonstrated the presence of an inherent surface superconducting phase in addition to the bulk superconducting phase. For the latter, the s-wave ...
Added: April 9, 2024
Особенности синтеза, структура, магнитометрия и ЯМР-спектроскопия нанопроволок различных типов
Загорский Д. Л., Долуденко И. М., Хайбулин Р. И. et al., Физика твердого тела 2022 Т. 64 № 9 С. 1153–1161
Исследованы различные типы нанопроволок, полученных методом матричного синтеза — гомогенные (из железа) и гетерогенные (слоевые). Разработана и описана методика получения массивов слоевых нанопроволок, с чередующимися тонкими слоями магнитных и немагнитных металлов (Co/Cu, Ni/Cu). Методами микроскопии (СЭМ и ПЭМ с элементным анализом) изучена топография получаемых структур, диаметры нанопроволок и толщины отдельных слоев, особенности межслоевых интерфейсов. Предложены способы синтеза нанопроволок с тонкими ...
Added: December 6, 2023
Diversity of Structural, Dynamic, and Environmental Effects Explain a Distinctive Functional Role of Transmembrane Domains in the Insulin Receptor Subfamily
Bershatsky Y., Kuznetsov A., Idiatullina A. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 4 Article 3906
Human InsR, IGF1R, and IRR receptor tyrosine kinases (RTK) of the insulin receptor subfamily play an important role in signaling pathways for a wide range of physiological processes and are directly associated with many pathologies, including neurodegenerative diseases. The disulfide-linked dimeric structure of these receptors is unique among RTKs. Sharing high sequence and structure homology, the receptors differ dramatically ...
Added: May 19, 2023
  • About
  • About
  • Key Figures & Facts
  • Sustainability at HSE University
  • Faculties & Departments
  • International Partnerships
  • Faculty & Staff
  • HSE Buildings
  • HSE University for Persons with Disabilities
  • Public Enquiries
  • Studies
  • Admissions
  • Programme Catalogue
  • Undergraduate
  • Graduate
  • Exchange Programmes
  • Summer University
  • Summer Schools
  • Semester in Moscow
  • Business Internship
  • Research
  • International Laboratories
  • Research Centres
  • Research Projects
  • Monitoring Studies
  • Conferences & Seminars
  • Academic Jobs
  • Yasin (April) International Academic Conference on Economic and Social Development
  • Media & Resources
  • Publications by staff
  • HSE Journals
  • Publishing House
  • iq.hse.ru: commentary by HSE experts
  • Library
  • Economic & Social Data Archive
  • Video
  • HSE Repository of Socio-Economic Information
  • HSE1993–2026
  • Contacts
  • Copyright
  • Privacy Policy
  • Site Map
Edit