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Первый дженерик тирзепатида GP30931: физико-химическое и биологическое сходство с референтным лекарственным средством
Разработка и регистрация лекарственных средств. 2025. Т. 14. № 2. С. 54–74.
Луговик И. А., Бабина А. В., Арутюнян С. С., Ермолаева Д. О., Сапарова В. Б., Кобелева Т. Н., Заикин П. Г., Микушина А. Д., Букатин А. С., Eliseev I., Зайчик Б. Ц., Керученько Я. К., Охрименко И. С., Бочаров Э. В., Тальдаев А. Х., Лушпа В. А., Макаренко И. Е., Драй Р. В.
Nersisyan A., Frontiers in Molecular Biosciences 2026 Vol. 13 Article 1995001
Antiviral activity is commonly summarized using endpoint measures such as EC50 or EC90, yet these quantities emerge from a dynamic biological system and depend on viral replication kinetics, host-cell properties, experimental design, and the assay used to quantify infection. Infectious-virus titers, viral RNA, infected-cell fractions, viability measurements, and immune readouts capture different components of the ...
Added: October 15, 2026
Тукачев Н. В., González-Jiménez M., Ramakrishnan G. et al., Physical Chemistry Chemical Physics 2021 Vol. 23 No. 23 P. 13250–13260
Low-frequency vibrations play an essential role in biomolecular processes involving DNA such as gene expression, charge transfer, drug intercalation, and DNA–protein recognition. However, understanding the vibrational basis of these mechanisms relies on theoretical models due to the lack of experimental evidence. Here we present the low-frequency vibrational spectra of G-quadruplexes (structures formed by four strands ...
Added: October 14, 2026
Батова О. Н., Савинецкая Л. Е., Проявка С. В. et al., Nature Conservation Research. Заповедная наука 2026 Т. 11 № 4 С. 25–39
Spermophilus suslicus is a threatened species listed in Red Data Books at all levels (from regional Red Data
Books to the IUCN Red List of Threatened Species), and it currently requires special conservation activity.
Over the past 30–50 years, its range has changed from continuous to mosaic, and its population has declined
everywhere. In 2015, in Russia experimental ...
Added: October 13, 2026
Temereva E., Zoologischer Anzeiger 2026 Vol. 325 P. 182–195
Brachiopoda is a group of animals, that is still insufficiently studied at the ultrastructural level, despite the significance of ultrastructure of tissues and organs for analysing the functional morphology, reconstructing the organisation and biology of numerous extinct brachiopods, and establishing relationships among major taxa. In the present study, we provide a revised reconstruction of the ...
Added: October 11, 2026
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91
Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...
Added: September 29, 2026
ARUTYUNOV G. P., TARLOVSKAYA E. I., POLYAKOV D. S. et al., Heliyon 2024 Vol. 10 No. 7 Article e28892
The aim of this study is to investigate the course of the acute period of COVID-19 and devise a prognostic scale for patients hospitalized.
Materials and methods
The ACTIV registry encompassed both male and female patients aged 18 years and above, who were diagnosed with COVID-19 and subsequently hospitalized. Between June 2020 and March 2021, a total ...
Added: September 28, 2026
Арутюнов Г. П., Тарловская Е. И., Батлук Т. И. et al., Российский кардиологический журнал 2025 Т. 30 № 10 С. 111–120
The use of beta-blockers (BB) plays a crucial role in the treatment of cardiovascular diseases. However, there are significant discrepancies with current guidelines in real-world practice. The main issues related to suboptimal dosing regimens and poor medication adherence reduce the effectiveness of therapy and worsen the prognosis of patients. Under the auspices of the Eurasian ...
Added: September 28, 2026
Арутюнов Г. П., Батлук Т. И., Башкинов Р. А. et al., Клиническая медицина 2025 Т. 103 № 4 С. 309–313
Recurrent Pericarditis (RP) is a significant medical issue despite advancements in modern cardiology. The management of patients with this condition is associated with several challenges due to the variety of clinical manifestations, difficulties in differential diagnosis, lack of standardized treatment protocols, and a high likelihood of recurrences. Furthermore, there is insufficient data in the literature ...
Added: September 28, 2026
Lin Z., Duan K., Wan R. et al., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Volynsky P., Urban A., Pavlov K. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 2 Article 553
Alzheimer’s disease (AD) pathogenesis is correlated with the membrane content
of various lipid species, including cholesterol, whose interactions with amyloid precursor
protein (APP) have been extensively explored. Amyloid-β peptides triggering AD are
products of APP cleavage by secretases, which differ depending on the APP and secretase location
relative to ordered or disordered membrane microdomains. We used high-resolution
NMR to probe ...
Added: October 12, 2025
Petrova A., Mamin G., Gnezdilov O. et al., Polymers 2023 Vol. 15 No. 22 P. 4445–4460
The synthesis of biocompatible and bioresorbable composite materials, such as a “polymer matrix-mineral constituent,” stimulating the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine and materials science. Composite films of bioresorbable polymer of polyvinylpyrrolidone (PVP) and hydroxyapatite (HA) were obtained. ...
Added: August 13, 2025
Konshina A., Bocharov E., Konovalova E. et al., International Journal of Molecular Sciences (Швейцария) 2024 Vol. 25 No. 21 Article 11370
Non-immunoglobulin-based scaffold proteins (SPs) represent one of the key therapeutic
target-specific and high-affinity binders in modern medicine. Among their cellular targets are signaling
receptors, in particular, receptor tyrosine kinases, whose dysfunction leads to the development
of cancer and other serious diseases. Successful applications of SPs have been reported for
HER receptor type 2 (HER2), a member of the human ...
Added: December 9, 2024
El-Mowafi S. A., Konshina A. G., Mohammed E. H. et al., Molecules 2023 Vol. 28 No. 24 Article 8049
In our ongoing quest to design effective antimicrobial peptides (AMPs), this study aimed to elucidate the mechanisms governing cyclic amphiphilic AMPs and their interactions with membranes. The objective was to discern the nature of these interactions and understand how peptide sequence and structure influence antimicrobial activity. We introduced modifications into the established cyclic AMP peptide, ...
Added: September 15, 2024
Gippius A. A., Gunbin A. V., Tkachev A. V. et al., Intermetallics 2023 Vol. 163 Article 108063
A comprehensive study of the intermetallic superconductor Mo8Ga41 was conducted by means of HRPXRD, abinitio calculations, NMR and NQR spectroscopy on 69Ga and 71Ga nuclei, as well as tunneling spectroscopy. All experimental methods used demonstrated the presence of an inherent surface superconducting phase in addition to the bulk superconducting phase. For the latter, the s-wave ...
Added: April 9, 2024
Загорский Д. Л., Долуденко И. М., Хайбулин Р. И. et al., Физика твердого тела 2022 Т. 64 № 9 С. 1153–1161
Исследованы различные типы нанопроволок, полученных методом матричного синтеза — гомогенные
(из железа) и гетерогенные (слоевые). Разработана и описана методика получения массивов слоевых
нанопроволок, с чередующимися тонкими слоями магнитных и немагнитных металлов (Co/Cu, Ni/Cu).
Методами микроскопии (СЭМ и ПЭМ с элементным анализом) изучена топография получаемых структур,
диаметры нанопроволок и толщины отдельных слоев, особенности межслоевых интерфейсов. Предложены
способы синтеза нанопроволок с тонкими ...
Added: December 6, 2023
Bershatsky Y., Kuznetsov A., Idiatullina A. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 4 Article 3906
Human InsR, IGF1R, and IRR receptor tyrosine kinases (RTK) of the insulin receptor
subfamily play an important role in signaling pathways for a wide range of physiological processes
and are directly associated with many pathologies, including neurodegenerative diseases. The
disulfide-linked dimeric structure of these receptors is unique among RTKs. Sharing high sequence
and structure homology, the receptors differ dramatically ...
Added: May 19, 2023
Чеботарева О. Е., В кн.: Международные Четвериковские чтения: сборник трудов конференции (26-27 апреля 2021 г., Пущино, Московская область, Россия).: Пущино: Фонд "Предприниматели за развитие города Пущино", 2021. С. 53–57.
Рекомбинантный белок - это белок, претерпевший определённые модифицикации и кодирующийся рекомбинантной (модифицированной) ДНК. Рекомбинантная ДНК как правило представляет собой плазмиду, в которой ген (или гены - их может быть несколько) целевого белка, располагается после промоторной области. Когда плазмида вводится в систему экспрессии хозяина, его белок-синтезирующий аппарат обеспечивает продукцию 54 выбранного белка. Это позволяет получить большие ...
Added: May 13, 2023
Voronin A., Sofya P. Balabanova, Fedyanin I. et al., Molecules 2022 Vol. 27 No. 19 Article 6287
A strategy for the synthesis of 5-((2-cyanoethyl)-X-amino)-[1,2,3]triazolo[4,5-c][1,2,5]oxadiazol-5-ium-4-ides (X = H; CH2CH2CN; NO2 (4a); CN (4b); CO2Et (4c)) starting from 3-amino-4-azido-1,2,5-oxadiazole was developed. The key step in this strategy is the intramolecular thermolytic cyclization of the azido group and the bis(2-cyanoethyl)triazene group. Removal of the 2-cyanoethyl protecting group from amides 4a–c gave potassium salt of the corresponding nitramide and ...
Added: January 31, 2023
Goncharuk M., Baleeva N., Nolde Dmitry E. et al., Communications Biology 2022 Vol. 5 Article 706
“Fluorescence-Activating and absorption-Shifting Tag” (FAST) is a well-studied fluorogenactivating
protein with high brightness and low size, able to activate a wide range of
fluorogens. This makes FAST a promising target for both protein and fluorogen optimization.
Here, we describe the structure-based rational design of the enhanced FAST mutants,
optimized for the N871b fluorogen. Using the spatial structure of the ...
Added: August 1, 2022
Novikov V., Нелюбина Ю. В., Успехи химии 2021 Т. 90 № 10 С. 1330–1358
Many paramagnetic metal complexes have emerged as unique magnetic materials (single-molecule magnets), which behave as conventional magnets at the single-molecule level, thereby making it possible to use them in modern devices for data storage and processing. The rational design of these complexes, however, requires a deep understanding of the physical laws behind a single-molecule magnet ...
Added: March 18, 2022