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July 13, 2026
Biologists Discover Unique Properties of MiR-93-5p MicroRNA in Prostate Cancer
Researchers at the International Laboratory of Microphysiological Systems of the HSE Faculty of Biology and Biotechnology investigated how different isoforms of the same microRNA influence gene function in prostate adenocarcinoma. The study found that in some cases, microRNAs can reinforce each other’s effects by targeting and suppressing the same genes. This finding offers a fresh perspective on the molecular mechanisms underlying tumour development and on the search for disease biomarkers. The results have been published in PeerJ.
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Numerical simulation of lightning channel reactivation in recoil leader process

Atmospheric Research. 2025. Vol. 323. Article 108187.
D.I. Iudin, N.L. Aleksandrov, Syssoev A. A., A.A. Ponomarev

Lightning development involves transient events that produce non-stationary, abrupt changes in lightning structure. The most prominent (and most studied) examples of reactivation of lightning side branches are recoil leaders that are initiated near the tips of previously decayed positive leader channels. This study proposes a numerical model that, among other things, takes into account evolution of channel temperature profile and is aimed at simulation the recoil leader inception. The model is based on the paradigm of reversal point meandering, which is a consequence of the macroscale asymmetry of development of positive and negative lightning poles. Simulation results allow one for the first time to formulate a physically-based and well-founded mechanism of a negative recoil leader initiation. In particular, it is shown that the channel reactivation is pro vided by the wave of electric field that starts from the branching point and propagates along a previously decayed (but still heated) leader channel when its per-unit-length resistance does not exceed several thousand Ohms per meter. This resistance corresponds to the channel temperature no less than ∼3500 K under equilibrium conditions. It is shown that channel reactivation starts somewhere between the branching point and the previ ously decayed leader tip, in agreement with observations. Additionally, the plasma chemical aspects of the leader channel reactivation are discussed.

Research target: Physics
Language: English
DOI
Text on another site
Keywords: численное моделированиеNumerical simulationRecoil leaderionization waveионизационная волнаLightning channel reactivationReversal point driftChannel thermodynamicsТермодинамика молниевого каналареактивация молниевого канала
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