IITP RAS, 2023
В сборнике представлены тезисы работ участников 11-ой Московской конференции по вычислительной молекулярной биологии MCCMB'23. Работы посвящены актуальным вопросам анализа аминокислотных и нуклеотидных последовательностей, структур биополимеров, молекулярной эволюции, методов высокопроизводительного секвенирования, системной биологии и биоалгоритмов. ...
Added: November 30, 2023
Здоровье всегда являлось весомым капиталом человека, а грамотное распоряжением им всегда приносило ощутимые инвестиции. В современном мире с его темпами, задачами и вызовами у большинства людей все меньше времени остается на сохранение, поддержание и тем более укрепление здоровья. Но на возникающий запрос, формируется решение, продиктованное самим обществом, а именно, его цифровым отражением. Оцифровка общественной и ...
Added: May 15, 2023
Lubashevsky I., Gafiychuk V., Lviv : VNTL Publishers, 1999
In the present monograph we formulate mathematical model for heat transfer in living tissue with self-regulation. Basing on the well known equivalence of the diffusion type process and random walks, we develop a certain regular procedure that enables us to average the mesoscopic equations describing heat transfer in living tissue practically over all scales of ...
Added: November 5, 2021
Ragimova A., Петелин Д. С., Захарова Н. В. et al., М. : Центральная государственная медицинская академия Управления делами Президента Российской Федерации, 2019
This training manual contains information about the features of the use of transcranial magnetic stimulation (TMS) in the main mental and neuropsychiatric disorders. The manual discusses in detail the main mechanisms of action of TMS, legal, organizational and sanitary norms of this procedure, indications and contraindications for its implementation, the peculiarities of combining TMS with ...
Added: December 11, 2020
Кудрявая Н. В., Зорин К. В., Смирнова Н. Б. et al., Алматы : ССК, 2018
В учебном пособии коллектива авторов представлены содержательные материалы по актуальной проблеме - нравственно-просветительской работе врача. Эта проблема анализируется с точки зрения антропологии, педагогики и психологии. Подробно рассматриваются взгляды ученых и мыслителей на соотношение духовного, душевного и телесного в человеке. на развитие личности, на взаимосвязь высших ценностей, смыслов и самоактуализации в профессиональной деятельности.. Особое внимание в ...
Added: July 21, 2020
М. : Издательство "Медицинское информационное агентство", 2019
Издание может быть использовано в качестве учебного пособия для студентов, обучающихся по специальностям 30.05.02 "Медицинская биофизика", 30.05.01 "Медицинская биохимия", 31.05.01 "Лечебное дело (врач-исследователь)" в соответствии с учебными программами ФГОС-3.1.
Для врачей клиницистов, эпидемиологов и биофизиков. ...
Added: December 11, 2018
EasyChair, 2018
This volume contains proceedings of the first Workshop on Data Analysis in Medicine held in May 2017 at the National Research University Higher School of Economics, Moscow. The volume contains one invited paper by Dr. Svetla Boytcheva, 6 regular contributions and 2 project proposals, carefully selected and reviewed by at least two reviewers from the ...
Added: June 8, 2018
Krivonosov M., Nazarenko T., Bacalini M. G. et al., Chaos, Solitons and Fractals 2022 Vol. 165 Article 112863
Despite the fact that the cause of Down Syndrome (DS) is well established, the underlying molecular mechanisms that contribute to the syndrome and the phenotype of accelerated aging remain largely unknown. DNA methylation profiles are largely altered in DS, but it remains unclear how different methylation regions and probes are structured into a network of interactions. We ...
Added: March 12, 2024
Sushentsev N., Rundo L., Abrego L. et al., European Radiology 2023 Vol. 33 No. 6 P. 3792-3800
Serial MRI is an essential assessment tool in prostate cancer (PCa) patients enrolled on active surveillance (AS). However, it has only moderate sensitivity for predicting histopathological tumour progression at follow-up, which is in part due to the subjective nature of its clinical reporting and variation among centres and readers. In this study, we used a ...
Added: February 28, 2024
Nené N. R., Ney A., Nazarenko T. et al., Communications Medicine 2023 Vol. 3 No. 1 Article 10
Nene et al. construct machine learning models based on serum protein biomarker data to detect pancreatic ductal adenocarcinoma in a nested case-control study from the UKCTOCS cohort. Their ensemble modelling approach outperforms existing combinations of biomarkers.
BackgroundEarlier detection of pancreatic ductal adenocarcinoma (PDAC) is key to improving patient outcomes, as it is mostly detected at advanced ...
Added: February 28, 2024
Peasley R., Rangel L. A., Casagrandi D. et al., Ultrasound in Obstetrics and Gynecology 2023 Vol. 62 No. 1 P. 106-114
ObjectivesThere is limited prospective evidence to guide the management of late-onset fetal growth restriction (FGR) and its differentiation from small-for-gestational age. The aim of this study was to assess prospectively a novel protocol in which ultrasound criteria were used to classify women with suspected late FGR into two groups: those at low risk, who were ...
Added: February 28, 2024
Yong H. E., Katarzyna M., Yusoff M. A. et al., Cells 2023 Vol. 12 No. 7
Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Altered placental formation and functional capacity are major contributors to FGR pathogenesis. Relating placental structure to function across the placenta in healthy and FGR pregnancies remains largely unexplored but could improve understanding of placental diseases. We investigated integration of these parameters spatially ...
Added: February 28, 2024
Pulkova N. V., Zyrina A. N., Mnafki N. A. et al., Bulletin of Experimental Biology and Medicine 2022 Vol. 173 No. 1 P. 146-150
Most drugs are metabolized in the liver, which can lead to their activation or inactivation with a change in the parent compound pharmacology, as well as liver damage by active metabolites. Preclinical animal studies of drug safety do not always predict its effect on humans due to species specificity. Thus, for the rapid drug screening, ...
Added: February 17, 2024
Lebedeva S., Margaryan A., Smolyarchuk E. et al., Frontiers in Endocrinology 2023 Vol. 14 Article 1176199
The diabetic kidney disease (DKD) is the major cause of the chronic kidney disease (CKD). Enhanced plasma vasopressin (VP) levels have been associated with the pathophysiology of DKD and CKD. Stimulation of VP release in DKD is caused by glucose-dependent reset of the osmostat leading to secondary pathophysiologic effects mediated by distinct VP receptor types. ...
Added: December 5, 2023
Ali S., Faizi B., Waqas H. et al., Kybernetes 2023 Vol. 52 No. 3 P. 1149-1170
The present study aims to identify and evaluate the socioeconomic barriers to effective COVID-19 pandemic transmission control in Pakistan.The study identifies multiple socio-economic barriers through an extensive literature review. The preliminary analysis unveiled 15 socio-economic barriers. Nine experts were contacted to collect data and finalize the most prominent barriers to COVID-19 transmission control using the ...
Added: November 18, 2023
Kuzin A., Chernyshev V., Kovalyuk V. et al., Applied Physics Letters 2023 Vol. 123 P. 1-5
Today, the search for disease biomarkers and techniques for their detection is one of the most important focuses in modern healthcare. Extracellular vesicles (EVs) are known to be related to the pathogenesis of various illnesses, such as cancer, neurodegenerative disease, and cardiovascular disease. Specific EV detection and potential control of their amount in biological fluids ...
Added: November 8, 2023
Kolosnitsyna M., Макарова М. В., Vladimirskaya A. et al., Электронный научный журнал "Социальные аспекты здоровья населения" 2023 № 5(69) Статья 14
Background. Malignant neoplasms can be caused by a genetic predisposition. The identification of clinically significant mutations enables to determine the risk of developing neoplasms of other localizations in patients and primary tumors in unaffected relatives. Besides, diagnosis of oncological diseases at an early stage increases the effectiveness of their treatment. One of the objectives of ...
Added: October 31, 2023
Sitovskaya D., Zabrodskaya Y., Parshakov P. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 19 Article 14490
The European Commission of the International League Against Epilepsy (ILAE) has identified glial mechanisms of seizures and epileptogenesis as top research priorities. The aim of our study was to conduct a comparative analysis of the expression levels of cytoskeletal proteins (glial fibrillar acidic protein (GFAP) and vimentin), protective protein S100, and proapoptotic caspase-3 protein in ...
Added: October 2, 2023
Introduction: In this study we examine whether social health markers measured at baseline are associated with differences in cognitive capability and in the rate of cognitive decline over an 11-to-18-year period among older adults and compare results across studies. Methods: We applied an integrated data analysis approach to 16,858 participants (mean age 65 years; 56% ...
Added: September 15, 2023
Knyazev E. N., Kalinin R. S., Abrikosova V. A. et al., Bulletin of Experimental Biology and Medicine 2023 Vol. 175 No. 1 P. 150-156
We studied the effect of KDM5 family demethylase inhibitors (JIB-04, PBIT, and KDOAM-25) on the penetration of SARS-CoV-2 pseudotyped viruses into differentiated Caco-2 cells and HEK293T cells with ACE2 hyperexpression. The above drugs were not cytotoxic. Only KDOAM-25 significantly reduced virus entry into the cells. The expression of ACE2 mRNA in Caco-2 significantly increased, while TMPRSS2 expression did not significantly change ...
Added: June 22, 2023
Kantserova A. O., Oknina L. B., Pitskhelauri D. I. et al., Neuroscience and Behavioral Physiology 2023 Vol. 53 No. 3 P. 358-364
Studies of neuron activity in animals have shown that the brainstem is involved in processing the ends of sounds. We report here an analysis of the reaction of the human midbrain to the ends of sound stimuli. Electrical activity was recorded using a depth electrode located in the cerebral aqueduct. The study was conducted as ...
Added: May 18, 2023
Discourse Diversity Database (3D) is a corpus designed for clinical linguistics research. It consists of oral speech samples of three different genres: picture-elicited narratives, personal stories, and picture-based instructions. The sub-sections of 3D include recordings by Russian speakers from three independent groups: people with brain tumors before and after tumor removal, people with schizophrenia, and neurologically ...
Added: January 25, 2023
Bezuglov E., Morgans R., Lazarev A. et al., Nutrients 2022 Vol. 14 No. 23 Article 5036
The purpose of this study was to evaluate the effect of a single intake of citrulline at 3 g and 6 g doses in adult elite soccer players performing sport-specific exercise. Materials and Methods: This randomized double-blind placebo-controlled study analyzed 18 soccer players from the top divisions of three European countries. Participants were randomized into ...
Added: December 27, 2022
Ntoumanis I., Agranovich O., Anna N. Shestakova et al., Journal of Personalized Medicine 2022 Vol. 12 No. 11 Article 1841
Embodied cognition theory suggests that motor dysfunctions affect cognition. We examined this hypothesis by inspecting whether cerebral processing of movies, featuring both goal-directed movements and content without humans, differ between children with congenital motor dysfunction and healthy controls. Electroencephalography was recorded from 23 healthy children and 23 children with limited or absent arm movement due ...
Added: December 9, 2022
Blagoveshchensky E., Агранович О. Е., Корякина М. М. et al., Журнал высшей нервной деятельности им. И.П. Павлова 2022 Т. 72 № 5 С. 690-696
Learning new movement skills is a critical factor in the treatment of certain motor disorders. For example, in the treatment of children with congenital biceps atrophy (arthrogryposis), an innovative technique is used involving autografting of donor muscles, which begin the role of the non-functioning biceps. In this case, after surgery, the patient is faced with ...
Added: December 8, 2022
Exact p-value (XPV)-based methods for dot product-like score functions -- such as the XCorr score implemented in Tide, SEQUEST, Comet or shared peak count-based scoring in MSGF+ and ASPV -- provide a fairly well calibration for peptide-spectrum-match (PSM) scoring in database searching-based MS/MS spectrum data identification. Unfortunately, standard XPV methods, in principle, cannot utilize the ...
Added: December 2, 2022
Acquaye F. L., Kertesz-Farkas A., Stafford Noble W., Journal of Proteome Research 2023 Vol. 22 No. 2 P. 577-584
The first step in the analysis of protein tandem mass spectrometry data typically involves searching the observed spectra against a protein database. During database search, the search engine must digest the proteins in the database into peptides, subject to digestion rules that are under user control. The choice of these digestion parameters, as well as ...
Added: December 2, 2022
Bazykin G., Danilenko D., Komissarov A. et al., / Research Square Company. Series ResearchSquare "Research Square". 2022.
Added: January 13, 2022
Klink G. V., Safina K. R., Nabieva E. et al., / Cold Spring Harbor Laboratory. Series 005140 "Medrxiv". 2021.
Background Delta has outcompeted most preexisting variants of SARS-CoV-2, becoming the globally predominant lineage by mid-2021. Its subsequent evolution has led to emergence of multiple sublineages, many of which are well-mixed between countries.
Aim Here, we aim to study the emergence and spread of the Delta lineage in Russia.
Methods We use a phylogeographic approach to infer imports of Delta ...
Added: December 6, 2021
Shchur V., Spirin V., Pokrovskiy V. et al., / Cold Spring Harbor Laboratory. Series 005140 "Medrxiv". 2021.
As an effort to help contain the COVID-19 pandemic, large numbers of SARS-CoV-2 genomes have been sequenced from all continents. More than one million viral sequences are publicly available as of April 2021. Many studies estimate viral genealogies from these sequences, as these can provide valuable information about the spread of the pandemic across time ...
Added: April 27, 2021
Komissarov A. B., Safina K. R., Garushyants S. K. et al., / Cold Spring Harbor Laboratory. Series 005140 "Medrxiv". 2020.
The ongoing pandemic of SARS-CoV-2 presents novel challenges and opportunities for the use of phylogenetics to understand and control its spread. Here, we analyze the emergence of SARS-CoV-2 in Russia in March and April 2020. Combining phylogeographic analysis with travel history data, we estimate that the sampled viral diversity has originated from 67 closely timed ...
Added: July 17, 2020