Use of magnetoencephalography (MEG) for the functional motor cortex localization: extraction and localization of the motor component in movement preparation processes by Independent Component Analysis

Pronko Platon K.; Chayanov N.V.; Prokofyev A.O.; Chernyshev V. Boris; Stroganova T.A.

Book chapter

Use of magnetoencephalography (MEG) for the functional motor cortex localization: extraction and localization of the motor component in movement preparation processes by Independent Component Analysis

P. 41-42.

Pronko P. K., Chayanov N., Prokofyev A., Chernyshev V. Boris, Stroganova T.

The problem of non-invasive preoperative localization of motor areas in human cortex has not been solved yet. In clinical practice, localization of the hand representation in the primary motor cortex often becomes one of the main goals of the pre-surgical evaluation. In healthy subjects the area of the motor hand representation usually corresponds to certain standard anatomical landmarks (hand knob in the precentral gyrus), which can be easily found in sMRI images. Unfortunately, in patients with various brain lesions these landmarks may be absent or not corresponding to the area of the motor cortex. In such cases, location of irreplacable areas must be determined according to their functional and/or temporal dynamical characteristics.

It might become a promising method of localizing primary motor area by way of taking into account the characteristic properties of the primary motor cortex temporal dynamics during movement preparation.

Language: English

Keywords: non-invasive preoperative localization motor areas human cortex Independent Component Analysis MEG motor component

Publication based on the results of: The Psychophysiology of Sustained Attention and Perception in Conditions of Impeded Decision Making in Relation to Individual Differences(2012)

In book

International Symposium on Functional Neuroimaging: Basic Research and Clinical Applications. Abstracts

Edited by: S. Novikova,. MSUPE, 2012.

Phase shift invariant imaging of coherent sources (PSIICOS) from MEG data.

Ossadtchi A., Altukhov D., Jerbi K. Neuroimage. 2018. Vol. 183. P. 950-971.

Increasing evidence suggests that neuronal communication is a defining property of functionally specialized brain networks and that it is implemented through synchronization between population activities of distinct brain areas. The detection of long-range coupling in electroencephalography (EEG) and magnetoencephalography (MEG) data using conventional metrics (such as coherence or phase-locking value) is by definition contaminated by spatial leakage. Methods such as imaginary coherence, phase-lag index or orthogonalized amplitude correlations tackle spatial leakage by ignoring zero-phase interactions. Although useful, these metrics will by construction lead to false negatives in cases where true zero-phase coupling exists in the data and will underestimate interactions with phase lags in the vicinity of zero. Yet, empirically observed neuronal synchrony in invasive recordings indicates that it is not uncommon to find zero or close-to-zero phase lag between the activity profiles of coupled neuronal assemblies. Here, we introduce a novel method that allows us to mitigate the undesired spatial leakage effects and detect zero and near zero phase interactions. To this end, we propose a projection operation that operates on sensor-space cross-spectrum and suppresses the spatial leakage contribution but retains the true zero-phase interaction component. We then solve the network estimation task as a source estimation problem defined in the product space of interacting source topographies. We show how this framework provides reliable interaction detection for all phase-lag values and we thus refer to the method as Phase Shift Invariant Imaging of Coherent Sources (PSIICOS). Realistic simulations demonstrate that PSIICOS has better detector characteristics than existing interaction metrics. Finally, we illustrate the performance of PSIICOS by applying it to real MEG dataset recorded during a standard mental rotation task. Taken together, using analytical derivations, data simulations and real brain data, this study presents a novel source-space MEG/EEG connectivity method that overcomes previous limitations and for the first time allows for the estimation of true zero-phase coupling via non-invasive electrophysiological recordings.

Added: Nov 30, 2018

MEG evidence for surround suppression effect in human early visual cortex during illusory contour processing

Chernyshev B. V., Pronko P. K., Kravchenko A. et al. In bk.: Cognitive control, communication and perception (CCCP): Psychological and neurobiological aspects. M.: Higher School of Economics Publishing House, 2014. P. 27-27.

MEG evidence for surround suppression effect in human early visual cortex during illusory contour processing

Added: Dec 22, 2014

Methods of data processing in EEG/MEG/ Applied aspects of magneto- and electroencephalographic neuroimaging

Edited by: A. Butorina. M.: MSUPE, 2013.

The Abstract book contains the abstracts of the posters presentations of the participants of the Methodological school: Methods of data processing in EEg and MEG, Moscow, 16-30th of April, 2013. The School was devoted to the theoretical and practical aspects of the contemporary methods of the dynamic mapping of brain activity by analysis of multichannel MEG and EEG.

Added: Nov 17, 2013

Brain routes for reading in adults with and without autism: EMEG evidence

Moseley R., Pulvermuller F., Mohr B. et al. Journal of Autism and Developmental Disorders. 2014. Vol. 44. No. 1. P. 137-153.

Reading utilises at least two neural pathways. The temporal lexical route visually maps whole words to their lexical entries, whilst the nonlexical route decodes words phonologically via parietal cortex. Readers typically employ the lexical route for familiar words, but poor comprehension plus precocity at mechanically 'sounding out' words suggests that differences might exist in autism. Combined MEG/EEG recordings of adults with autistic spectrum conditions (ASC) and controls while reading revealed preferential recruitment of temporal areas in controls and additional parietal recruitment in ASC. Furthermore, a lack of differences between semantic word categories was consistent with previous suggestion that people with ASC may lack a 'default' lexical-semantic processing mode. These results are discussed with reference to dual-route models of reading.

Added: Oct 23, 2014

MEG study of social conformity

Zubarev I., Shestakova A., Klucharev V. et al. In bk.: The 19th Annual Meeting of the Organization for Human Brain Mapping (OHBM), June 16-20, 2013 at the Washington State Convention Center in Seattle, WA, USA. Seattle: 2013.

Added: Jan 28, 2014

MEG signature of social conformity: evidence from evoked and induced responses.

Zubarev I., Ossadtchi A., Klucharev V. et al. 1. 1. Центр Нейроэкономики и когнититвных исследований, 2014

Humans often adjust their behavior to match the group norms. In this study, we used magnetoencephalographic (MEG) source imaging to investigate the electromagnetic responses to the perceived mismatch between individual and group opinions. After participants were exposed to group opinion that conflicted with their own, we observed an evoked response in the posterior medial prefrontal cortex (pMPFC) occurring around 200 ms, corresponding to the feedback-related negativity (FRN) – a component of the evoked response associated with processing negative feedback and reinforcement learning. This response was accompanied by an increase in power of theta oscillations (4-8 Hz) over a number of frontal sites (including OFC and pMPFC). The magnitude of both evoked and induced responses to the perceived conflict with social norms was stronger in participants who showed relatively low conformity. Overall, our results suggest that the activation of the pMPFC following conflicts with group opinion, as recoded by MEG, may reflect an enhanced control state – a process complimentary to the reinforcement learning signal in the ventral striatum reported in previous studies of social conformity

Added: Oct 29, 2014

The modification of judgments in a group situation: MEG correlates of conformity

Zubarev I., Shestakova A., Ossadtchi A. et al. In bk.: Society for Neuroeconomics Annual Meeting, 27-29 September at EPFL, 2013, Lausanne, Switzerland. Lausanne: 2013.

Added: Jan 28, 2014

Methodological school: Methods of data processing in EEG and MEG. Applied aspects of magneto-and electroencephalographic neuroimaging. April, 16-30, 2013

M.: МГУ, 2013.

The Abstract book contains the abstracts of the posters presentations of the participants of the Methodological school: Methods of data processing in EEG and MEG, Moscow, 16-30th of April, 2013. The School was devoted to the theoretical and practical aspects of the contemporary methods of the dynamic mapping of brain activity by analysis of multichannel MEG and EEG.

Added: Jun 4, 2013

Exploratory meg study of the illusory contour perception: positive and inverted effects

Evina E., Pronko P. K., Goyaeva D. E. et al. PSYCHOLOGY. WP BRP. Издательский дом НИУ ВШЭ, 2013. No. 07/PSY/2013.

The illusory contour is one of the most often used models in studies of Gestalt perception. In our MEG study we observed the so-called illusory contour effect (IC-effect): the activity of non-primary visual and associative cortical areas was increased during the 150-250 ms time window after a stimulus onset in response to illusory stimulus, compared with the control stimulus. In addition to the positive IC-effect, the inverted IC-effect was revealed for the first time in adults. In our study it was manifested during the 60-120 ms window after the onset of stimulus. The in-verted IC-effect is an early decrease in the activity of the visual cortex in response to the illusory contour compared with the control stimulus. The mechanism of the inverted IC-effect is yet un-clear. The “bottom-up” and “top-down” hypotheses of the origin of the inverted IC-effect are discussed.

Added: Mar 4, 2013

Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study

Papadelis C., Ahtam B., Nazarova M. et al. Frontiers in Human Neuroscience. 2014.

Although cerebral palsy (CP) is among the most common causes of physical disability in early childhood, we know little about the functional and structural changes of this disorder in the developing brain. Here,we investigated with three different neuroimaging modalities [magnetoencephalography (MEG), diffusion tensor imaging (DTI), and resting-state fMRI] whether spastic CP is associated with functional and anatomical abnormalities in the sensorimotor network. Ten children participated in the study: four with diplegic CP (DCP), three with hemiplegic CP (HCP), and three typically developing (TD) children. Somatosensory (SS)-evoked fields (SEFs) were recorded in response to pneumatic stimuli applied to digits D1, D3, and D5 of both hands. Several parameters of water diffusion were calculated from DTI between the thalamus and the pre-central and post-central gyri in both hemispheres. The sensorimotor resting-state networks (RSNs) were examined by using an independent component analysis method. Tactile stimulation of the fingers elicited the first prominent cortical response at ~50 ms, in all except one child, localized over the primary SS cortex (S1). In five CP children, abnormal somatotopic organization was observed in the affected (or more affected) hemisphere. Euclidean distances were markedly different between the two hemispheres in the HCP children, and between DCP and TD children for both hemispheres. DTI analysis revealed decreased fractional anisotropy and increased apparent diffusion coefficient for the thalamocortical pathways in the more affected compared to less affected hemisphere in CP children. Resting-state functional MRI results indicated absent and/or abnormal sensorimotor RSNs for children with HCP and DCP consistent with the severity and location of their lesions. Our findings suggest an abnormal SS processing mechanism in the sensorimotor network of children with CP possibly as a result of diminished thalamocortical projections.

Added: Oct 23, 2014