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Predictive mathematical modelling of recurrence periods for the secondary distant metastases in patients with ER/PR/HER2/Ki-67 subtypes of breast cancer
Ch. S60. P. 60–61.
P108 - Predictive mathematical modelling of recurrence periods for the secondary distant metastases in patients with ER/PR/HER2/Ki-67 subtypes of breast cancer
In book
Vol. 56. Issue Supplement 1. , Switzerland: Elsevier, 2021.
Sofya Nartova-Bochaver, Zolotareva A., Delvecchio E. et al., International Journal of Psychology 2025 Vol. 60 No. 5 Article 70096
Hedonic and eudaimonic well-being were studied depending on indicators of distress in countries with cultures differing in survival/self-realisation values. A total of 2216 respondents from Chile, China, Italy, Russia and the United States participated. The Psychological Well-Being Scale, the Satisfaction With Life Scale, and the Depression, Anxiety, Stress Scale were used. Findings provided evidence that in countries with high survival ...
Added: August 3, 2025
Silkina M., Razumovskaya A., Timur Kulagin et al., Biochimie 2025 Vol. 234 P. 48–61
Breast cancer remains a major challenge and new therapeutic approaches are needed for its treatment. Ferroptosis is considered a promising alternative cell death mechanism to eliminate resistant cancer cells. In previous works, we identified that lower IGFBP6 gene expression in tumor tissue corresponds to a worse prognosis for breast cancer patients and, at the same, time makes ...
Added: April 9, 2025
Razumovskaya A., Кулагин Т. А., Fatkulin A. et al., Биотехнология 2024 Т. 40 № 6 С. 74–83
To date, breast cancer is the most common oncological pathology among the female population both in Russia and worldwide. Previously, our laboratory team identified a significant prognostic marker for breast cancer, namely the ELOVL5 gene, the expression level of which in couple with the IGFBP6 gene allowed to predict the probability of breast cancer recurrence ...
Added: November 11, 2024
Заридзе Д. Г., Popovich L., Мукерия А. Ф. et al., Общественное здоровье 2024 Т. 4 № 3 С. 30–38
Introduction. In 2021, the results of the first large-scale prospective cohort study were published showing the negative impact of post-diagnosis smoking on the prognosis of non-small cell lung cancer (I-IIIа). The purpose of the study is to assess the possible benefits of postdiagnosis smoking cessation of patients with non-small cell lung cancer (NSLC) stage I–IIIa ...
Added: October 1, 2024
Shkurnikov M., Darya Averinskaya, Stekolshchikova E. et al., Biochimie 2024 Vol. 227 P. 77–85
Breast cancer recurrence is associated with the growth of disseminated cancer cells that separate from the primary tumor before surgical treatment and hormonal therapy and form a metastatic niche in distant organs. We previously demonstrated that IGFBP6 expression is associated with the risk of early relapse of luminal breast cancer. Knockdown of IGFBP6 in MDA-MB-231 breast cancer ...
Added: August 14, 2024
Власенко А. О., Sukharev A., Урюпин И. В., Управление большими системами: сборник трудов 2023 № 104 С. 73–99
The aim of this article is to define and to describe the calculation methodology for both on-point and general quantitative indicators of air transportation system quality for a passenger. The indicators can be based on any of the three common measures of path-passing (time, cost, and distance). The pair of values that is proposed to ...
Added: January 12, 2024
Osiyevskyy O., Shirokova G., Ehsani M., International Journal of Entrepreneurial Behaviour and Research 2023 Vol. 29 No. 7 P. 1664–1697
Purpose – Economy-wide crises create major challenges for small and medium enterprises (SMEs). Existing studies emphasize the crucial role of contrasting behavioral strategies, effectuation and causation in SMEs’ adaptation to crisis conditions. Yet, prior literature concentrated predominantly on exploring the impact of effectuation and causation on firm performance rather than survival. The authors present and ...
Added: July 14, 2023
Смирнов И. А., Черкесова Л. В., Поркшеян В. М. et al., IEEE, 2019.
In the offered examination the mathematical modelling of interaction processes of electromagnetic waves with composite substances nanostructures and electrodynamic structures on the base of graphene and carbon nanotubes is made. Models are grounded on solution of diffraction boundary-value 3D problems for Maxwell's equations with electrodynamic boundary conditions. Principles of subTHz and THz frequency bands controlled ...
Added: May 10, 2023
Nikulin S., Razumovskaya A., Poloznikov A. et al., Frontiers in Molecular Biosciences 2023 Vol. 10 Article 1075704
Relapse of breast cancer is one of the key obstacles to successful treatment. Previously we have shown that low expression of ELOVL5 and IGFBP6 genes in breast cancer tissue corresponded to poor prognosis. ELOVL5 participates directly in the elongation of polyunsaturated fatty acids (PUFAs) that are considered to play an important role in cancer cell metabolism. Thus, in this work we ...
Added: February 22, 2023
Cham: Springer, 2021.
Introduces new results in methods, problems and applications of operator theory and harmonic analysis by leading researchers
Presents the fundamentals of theory followed by recent developments in PDE’s, mathematical modelling, bioinformatics, and a discussion of real-world problems
Focuses on the very new trends in operator theory and function spaces theory, such as variable exponent spaces and objects ...
Added: December 25, 2022
Springer, 2022.
Presents the latest research in the field of reliability engineering applications. Signposts areas for useful future research. A Useful reference to engineers, researchers and advanced students in reliability engineering ...
Added: December 16, 2022
Морозов Н. Ю., Гришин Е. М., Правдивец Н. А. et al., Управление большими системами: сборник трудов 2022 № 99 С. 135–156
В связи с ростом объема мультимодальных перевозок ОАО «РЖД» требуется более эффективное использование имеющихся ресурсов. В наши дни наиболее востребованной разновидностью международного грузооборота является доставка морским транспортом с последующей перегрузкой на железную дорогу для доставки до пункта назначения на материке. В настоящей статье предлагается комплексная математическая модель, включающая две подзадачи: задачу назначения причалов (BAP) и ...
Added: December 7, 2022
Nersisyan S., Zhiyanov A., Еngibaryan N. et al., Frontiers in Genetics 2022 Vol. 13 Article 1070528
A widely used procedure for selecting significant miRNA-mRNA or isomiR-mRNA pairs out of predicted interactions involves calculating the correlation between expression levels of miRNAs/isomiRs and mRNAs in a series of samples. In this manuscript, we aimed to assess the validity of this procedure by comparing isomiR-mRNA correlation profiles in sets of sequence-based predicted target mRNAs ...
Added: December 1, 2022
Tikhonov N. A., Tokmachev M., Bakhia T. et al., Journal of Mathematical Chemistry 2021 Vol. 59 No. 4 P. 1054–1067
An electrochemical cell was created and experimentally tested and the process of intense capacitive deionization (CDI) of aqueous solutions in a cyclic mode was studied. The paper presents a developed mathematical model for CDI process on electrodes with complex structure of pore space. This allows to describe the process and obtain results that are in ...
Added: November 17, 2022
Beniaminov A., Grigory A. Puzanov, Krasnov G. et al., Frontiers in Genetics 2018 Vol. 9 No. 169
Hypermethylation of promoter CpG islands is generally recognized epigenetic mechanism responsible for gene silencing in cancer. However, molecular details on how this epigenetic mark triggers the process of gene downregulation are still elusive. Here, we used deep bisulfite sequencing and qPCR analysis to investigate the pattern of CpG methylation of ALDH1L1 promoter region and its association with ...
Added: October 11, 2022
Sergey Smetanin, Mathematics 2022 Vol. 10 No. 16 Article 2947
Policymakers and researchers worldwide are interested in measuring the subjective well-being (SWB) of populations. In recent years, new approaches to measuring SWB have begun to appear, using digital traces as the main source of information, and show potential to overcome the shortcomings of traditional survey-based methods. In this paper, we propose the formal model for ...
Added: August 15, 2022
Shigapova L., Chudakova D., Gordiev M. et al., Frontiers in Oncology 2018 Vol. 8
The Russian population consists of more than 100 ethnic groups, presenting a unique opportunity for the identification of hereditary pathogenic mutations. To gain insight into the landscape of heredity pathogenic variants, we employed targeted next-generation sequencing to analyze the germline mutation load in the DNA damage response and repair genes of hereditary breast and ovary ...
Added: June 20, 2022
Nikitin A., Chudakova D., Enikeev R. et al., Frontiers in Oncology 2020 Vol. 10 Article 666
Genome instability—the increased tendency of acquiring mutations in the genome and ability of a cell to tolerate high mutation burden—is one of the drivers of cancer. Genome instability results from many causes including defects in DNA repair systems. Previously, it has been shown that germline pathogenic mutations in DNA Mismatch Repair (MMR) pathway cause cancer-predisposing ...
Added: June 20, 2022
Kirillova A., Kovalskaya E., Brovkina Olga et al., Journal of Assisted Reproduction and Genetics 2020 Vol. 37 No. 4 P. 905–911
With the increased rate of stable remission after gonadotoxic cancer treatment, new methods of fertility preservation are required in order to provide the best possible care for oncological patients. Here, we report an original case of euploid blastocyst cryopreservation after in vitro maturation of ovarian tissue oocytes (OTO IVM). Thirty-three oocytes were obtained from the ...
Added: June 20, 2022
Nadon J., Epshtein V., Cameron E. et al., Communications Biology 2022 Vol. 5 No. 1 Article 457
Transcriptional pausing is crucial for the timely expression of genetic information. Biochemical methods quantify the half-life of paused RNA polymerase (RNAP) by monitoring restarting complexes across time. However, this approach may produce apparent half-lives that are longer than true pause escape rates in biological contexts where multiple consecutive pause sites are present. We show here ...
Added: May 13, 2022
Ksenia Gonchar, Greve M., Economic Systems 2022 Vol. 46 No. 2 Article 100975
Do political risks drive exit decisions by multinational companies (MNC)? What mechanisms can
protect a multinational subsidiary in a host country that is characterized by weak institutions and
high political risks? Using multinational plant-level data for Russia in the period 2000-2016 and
applying the Cox proportional hazard model, we find significant effects from elevated hostcountry
political risk when we ...
Added: April 19, 2022