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Regular version of the site

Book

Methionine dependence of cancer and aging: methods and protocols

Humana Press, 2019.
Манухов И. В.

Cancer cells require exogenous methionine for survival and therefore methionine restriction is a promising
avenue for treatment. The basis for methionine dependence in cancer cells is still not entirely clear. While
the lack of the methionine salvage enzyme methylthioadenosine phosphorylase (MTAP) is associated with
methionine auxotrophy in cancer cells, there are other causes for tumors to require exogenous methionine.
Restricting methionine by diet or by enzyme depletion, alone or in combination with certain chemotherapeutics,
is a promising antitumor strategy.






Chapters
Methionine dependence of cancer and aging: methods and protocols