Историко-культурный атлас Верхнеуслонского района Республики Татарстан. Карта культурного наследия
The Sebezh History museum’s collection contains two stones that resemble anthropomorphic figures. Unfortunately, their origin is known only from the words of K.M. Gromov, the museum director in the 1953–1970s. According to K.M. Gromov, one stone was found in a swamp near the village of Tekhomichi, 6 km from Sebezh. The only testimony of the idol veneration is the note by peasant of this village E.E. Glushakov, dating back to 1906. It describes the veneration of the stone by the villagers as giving healing, in particular from infertility. Unfortunately, its source is not known. Having already become a museum piece, the statue acquired the name Sebezhsky idol and the name Pestun (Fosterer), grammatically male, despite the fact that, according to the remarks of the museum staff, it is a female figure. Museum staff since the 1960s–1970s support the idea that the idol heals infertility and gives children. In the 1990s–2000s rites with the idol acquire some new details and prescriptions. So, now we have not only a formed ritual of worshiping a museum exhibit, but also the structure of his cult and a program of ritual practices, persistently proposed by the museum staff.
The article is a publication of some results of the EU project 2011 (Nordic Dimension, Partnership for Culture) – the study of Viking heritage objects in contemporary Russia. The potential of such objects, the existing infrastructure, possibilities to develop are under consideration.
One of the key advances in genome assembly that has led to a significant improvement in contig lengths has been improved algorithms for utilization of paired reads (mate-pairs). While in most assemblers, mate-pair information is used in a post-processing step, the recently proposed Paired de Bruijn Graph (PDBG) approach incorporates the mate-pair information directly in the assembly graph structure. However, the PDBG approach faces difficulties when the variation in the insert sizes is high. To address this problem, we first transform mate-pairs into edge-pair histograms that allow one to better estimate the distance between edges in the assembly graph that represent regions linked by multiple mate-pairs. Further, we combine the ideas of mate-pair transformation and PDBGs to construct new data structures for genome assembly: pathsets and pathset graphs.
Papers about natural protection territories
Many environmental stimuli present a quasi-rhythmic structure at different timescales that the brain needs to decompose and integrate. Cortical oscillations have been proposed as instruments of sensory de-multiplexing, i.e., the parallel processing of different frequency streams in sensory signals. Yet their causal role in such a process has never been demonstrated. Here, we used a neural microcircuit model to address whether coupled theta–gamma oscillations, as observed in human auditory cortex, could underpin the multiscale sensory analysis of speech. We show that, in continuous speech, theta oscillations can flexibly track the syllabic rhythm and temporally organize the phoneme-level response of gamma neurons into a code that enables syllable identification. The tracking of slow speech fluctuations by theta oscillations, and its coupling to gamma-spiking activity both appeared as critical features for accurate speech encoding. These results demonstrate that cortical oscillations can be a key instrument of speech de-multiplexing, parsing, and encoding.
Neuronal nicotinic acetylcholine receptors (NNRs) of the α7 subtype have been shown to contribute to the release of dopamine in the nucleus accumbens. The site of action and the underlying mechanism, however, are unclear. Here we applied a circuit modeling approach, supported by electrochemical in vivo recordings, to clarify this issue. Modeling revealed two potential mechanisms for the drop in accumbal dopamine efflux evoked by the selective α7 partial agonist TC-7020. TC-7020 could desensitize α7 NNRs located predominantly on dopamine neurons or glutamatergic afferents to them or, alternatively, activate α7 NNRs located on the glutamatergic afferents to GABAergic interneurons in the ventral tegmental area. Only the model based on desensitization, however, was able to explain the neutralizing effect of coapplied PNU-120596, a positive allosteric modulator. According to our results, the most likely sites of action are the preterminal α7 NNRs controlling glutamate release from cortical afferents to the nucleus accumbens. These findings offer a rationale for the further investigation of α7 NNR agonists as therapy for diseases associated with enhanced mesolimbic dopaminergic tone, such as schizophrenia and addiction