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September 7, 2026
Biologists Discover 'Molecular Fingerprint' of Preeclampsia
Researchers at HSE University employed a new method to model hypoxia in placental cells during pregnancies complicated by preeclampsia and identified molecular markers of tissue hypoxia. Since hypoxia is one of the key mechanisms underlying preeclampsia, these findings are important for a more accurate and timely diagnosis of the disease and for the development of effective treatment methods. The paper has been published in Placenta.
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Synthesis of multilevel knowledge graphs: Methods and technologies for dynamic networks

Engineering Applications of Artificial Intelligence. 2023. Vol. 123. Article 106244.
Man T., Vodyaho A., Ignatov D. I., Kulikov I., Zhukova N.

Knowledge Graphs is one of the most popular techniques for knowledge-based modelling in various subdomains of modern AI technologies ranging from natural language processing to e-commerce recommendations and cyberphysical systems. Even complex technical systems like telecommunication networks could be modelled by means of Knowledge Graphs. However, there are serious challenges when we deal with such systems having a huge number of interconnected elements (e.g. technical objects and their groups) that change over time. Thus, up-to-date there is no adequate solution for not only telecommunication networks but for any complex dynamic systems where inductive and deductive synthesis of large Knowledge Graph based models that are easily reconfigurable and scalable is required. We state and solve the problem of building such models for one of the most common types of objects where models can be represented as hierarchical re-configurable structures. This representation enables recent advances in multilevel inductive–deductive synthesis for model building. From a methodological viewpoint, we propose a novel complex approach to multilevel synthesis for objects with dynamic hierarchical structure based on modified methods for inductive and deductive synthesis of Knowledge Graphs. From a practical perspective we present a real case-study on an interactive service for digital cable TV networks – which is especially interesting for data engineers and scientists – where various problems ranging from network health monitoring to channel advertising can be solved with the same hierarchical model. We release an openly available domain benchmark, which features two realistic datasets (namely, for SPARQL querying performance analysis, and for our case study on dynamic network monitoring). Last but not least, our experiments with recent state-of-the-art approaches to knowledge graph querying Abdelaziz et al. (2017) show that the developed models of multilevel synthesis reduce the time complexity up to 73% on practice compared to the baselines, and are lossless and able to beat their competitors based on parallel knowledge graph processing from 4% to 91% in terms of computational time (depending on the query type). Further parallelisation of our multilevel models is even more efficient (the reduction of query processing time is about 40%–45%) and opens promising prospects for the creation and exploitation of dynamic Knowledge Graphs in practice.

Research target: Computer Science
Language: English
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Keywords: ontologyknowledge graphsMultilevel object modelInductive synthesisDeductive synthesisTelecommunication benchmark
Publication based on the results of:
Models and method for analysis of unstructured data, data mining and recommender systems (2023)
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