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Editorial: Pharmacological approaches targeting neutrophilic inflammation: Volume II
Frontiers in Pharmacology. 2022. No. 13. Article 1084026.
Neutrophils are essential for maintaining homeostasis and the functioning of the innate immune system. Neutrophils are the first immune cells to respond, and they release numerous types of substances that are crucial for eliminating microbes. However, it can also result in collateral tissue damage if neutrophilic activity is overdone. Thus, regulation of neutrophilic activity is of great importance for the treatment of many pathological conditions. The Research Topic aims to highlight the ongoing advancement in the pharmacological approaches targeting neutrophilic inflammation.
Гаврилова С. А., Буравков С. В., Кошелев В. Б. et al., Регионарное кровообращение и микроциркуляция 2013 Т. 12 № 3 (47) С. 39–46
In our work the dynamics of brain-derived neurotrophic factor expression and neuroprotective effects of Semax were investigated for the focal ischemia and focal ischemia with carotid artery reperfusion. BDNF mRNA expression dynamics is complex: BDNF reduced in the injured hemisphere at 3 and 7 hours after ischemia and increased expression of BDNF in the intact ...
Added: October 28, 2026
Четверикова М. М., Потемкин А. Н., Stepanova E., Бюллетень экспериментальной биологии и медицины 2026 Т. 182 № 9 С. 242–247
Gemcitabine, a first-line chemotherapeutic agent for bladder cancer (BC), often loses clinical efficacy due
to the development of drug resistance, the underlying mechanisms of which remain poorly understood. In
this work, a highly gemcitabine-resistant RT112/GR cell line was obtained by long-term selection. The MTT
assay revealed a 9312-fold decrease in gemcitabine sensitivity and moderate resistance to cisplatin (2.60-fold,
p ...
Added: October 26, 2026
Maltseva D., Tonevitsky A., Frontiers in Molecular Biosciences 2026 Vol. 13 P. 1–28
MicroRNA (miRNA) genes are frequently located in close proximity within the genome, forming so-called clusters. These clusters are transcribed as polycistronic units, suggesting coordinated transcriptional regulation of the miRNAs they contain. However, individual mature miRNAs from the same cluster often accumulate at varying levels and exhibit distinct tissue-specific expression patterns, indicating the presence of regulatory ...
Added: October 23, 2026
Vasilyev A., Svirin EP, Dubynin I. et al., Cortex 2025 Vol. 189 P. 76–96
Added: October 22, 2026
Karina V. Klycheva, Mariia O. Silkina, Dmitry M. Hushpulian et al., Biochemistry. Biokhimiia 2026 Vol. 91 P. 1842–1858
Involvement of the transcription factor Bach1 in various scenarios of cellular regulation is reviewed herein. To date, the most extensively studied role of Bach1 is that of a repressor of the antioxidant genetic program initiated by the Nrf2 factor. This program counteracts oxidative stress, which triggers both ferroptosis and the intrinsic apoptotic pathway. Bach1 functions unrelated ...
Added: October 22, 2026
Svirin E., Бердышев Д. А., Шишкин С. Л., Вестник Российского государственного медицинского университета 2026 № 3 С. 42–50
Quasi-movements (QMs), which are movement attempts minimized to the point of movement extinction, evoke EEG patterns similar to those of real movement. QMs can model attempted movement in healthy subjects and are therefore of interest as an alternative to motor imagery (MI) in rehabilitation brain–computer interfaces (BCIs), in which the attempted movement of the paralyzed ...
Added: October 22, 2026
Sitdikova K., Tsoy A., Chaprov K. et al., Journal of Neuropathology and Experimental Neurology 2026 Article nlag078
Understanding the earliest pathological changes in Alzheimer disease (AD) is critical for improving early intervention strategies. However, the relationship between amyloid plaque characteristics and early behavioral and molecular alterations remains unclear. We used 6-month-old female APPswe/PS1dE9 mice, a model of early amyloid-dominant pathology, to assess cognition and emotionality across a battery of behavioral tests. Amyloid ...
Added: October 22, 2026
Effects of Wheat Malt Extract on Molecular and Behavioral Markers in Aged APP/PS1 and Wild-Type Mice
Kassenova A., Svirin E., Sitdikova K. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 11 Article 4994
Added: October 22, 2026
Cespuglio R., Schmitt-Böhrer A., Deykin A. et al., Metabolites 2026 Vol. 16 No. 2 Article 117
Added: October 22, 2026
Logvenkov S. A., Известия РАН. Механика жидкости и газа 2026 № 3 С. 59–75
The problem of the evolution of cell volume fraction in a spherical aggregate composed of cells,
extracellular matrix, and fluid is considered. The aggregate is surrounded by extracellular matrix. The
problem formulation employs a multiphase model of a biological continuum, previously developed by the
author, consisting of two actively interacting solid phases and a fluid. The propagation of ...
Added: October 20, 2026
Liaukovich K., Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova 2026 Vol. 76 No. 5 P. 587–598
Added: October 19, 2026
Nersisyan A., Frontiers in Molecular Biosciences 2026 Vol. 13 Article 1995001
Antiviral activity is commonly summarized using endpoint measures such as EC50 or EC90, yet these quantities emerge from a dynamic biological system and depend on viral replication kinetics, host-cell properties, experimental design, and the assay used to quantify infection. Infectious-virus titers, viral RNA, infected-cell fractions, viability measurements, and immune readouts capture different components of the ...
Added: October 15, 2026
Тукачев Н. В., González-Jiménez M., Ramakrishnan G. et al., Physical Chemistry Chemical Physics 2021 Vol. 23 No. 23 P. 13250–13260
Low-frequency vibrations play an essential role in biomolecular processes involving DNA such as gene expression, charge transfer, drug intercalation, and DNA–protein recognition. However, understanding the vibrational basis of these mechanisms relies on theoretical models due to the lack of experimental evidence. Here we present the low-frequency vibrational spectra of G-quadruplexes (structures formed by four strands ...
Added: October 14, 2026
Батова О. Н., Савинецкая Л. Е., Проявка С. В. et al., Nature Conservation Research. Заповедная наука 2026 Т. 11 № 4 С. 25–39
Spermophilus suslicus is a threatened species listed in Red Data Books at all levels (from regional Red Data
Books to the IUCN Red List of Threatened Species), and it currently requires special conservation activity.
Over the past 30–50 years, its range has changed from continuous to mosaic, and its population has declined
everywhere. In 2015, in Russia experimental ...
Added: October 13, 2026
Temereva E., Zoologischer Anzeiger 2026 Vol. 325 P. 182–195
Brachiopoda is a group of animals, that is still insufficiently studied at the ultrastructural level, despite the significance of ultrastructure of tissues and organs for analysing the functional morphology, reconstructing the organisation and biology of numerous extinct brachiopods, and establishing relationships among major taxa. In the present study, we provide a revised reconstruction of the ...
Added: October 11, 2026
Urban dust nanoparticles drive inflammatory activation of human neutrophils and macrophages in vitro
Pavlyuchenkova A., Vorobjeva N., Ivaneev A. et al., Environmental Science and Pollution Research 2025 Vol. 32 P. 26541–26553
Today, the majority of the world’s population lives in urban environments, where they are constantly exposed to dust particles of varying sizes, including urban dust nanoparticles (NPs). The minute size of NPs ensures their quick and efficient penetration into inner body parts, where they can interact with many cell types, including epithelial, endothelial, and immune ...
Added: March 20, 2026
Chernyak B., Sokolov A., Hwang T. et al., Frontiers in Pharmacology (Швейцария) 2021 Vol. 12 Article 763140
Neutrophils are actively involved in the protection of our body against pathogen infection, but the consequences of their activation contribute significantly to pathogenesis of various diseases. This is why neutrophil-mediated responses should be finely tuned, and therapeutic interventions should balance between targeting neutrophil functions and uncontrolled neutrophil activation. Several decades ago, Elmer Becker wrote a ...
Added: December 10, 2022
Khashchenko E., Vysokikh M., Uvarova E. et al., Journal of Clinical Medicine 2020 Vol. 9 No. 5 P. 1399
Relevance: Mitochondrial dysfunction and systemic inflammation are believed to play pivotal role in the pathogenesis of polycystic ovary syndrome (PCOS) and related complications of metabolic disorders in adult patients. Though such researches are limited or almost absent in adolescents. The aim of the study is to evaluate the impact of mitochondrial dysfunction and systemic inflammation ...
Added: May 12, 2020