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Identification of key genes of the ccRCC subtype with poor prognosis
Scientific Reports. 2022. Vol. 12. No. 1. Article 14588.
Grigory Andreevich Puzanov
Clear cell renal carcinoma has been reported in many research studies as a rather heterogeneous disease. Identification of different subtypes and their molecular characteristics can help in choosing a more effective treatment and predicting a response to it. In this study, using multi-omics clustering of RNA-Seq data of patients with clear cell renal carcinoma from TCGA. Specific genes were identified for the most aggressive ccRCC subtype associated with metastasis and a subtype associated with a more favorable course of the disease. Among them were genes associated with blood clotting (FGA, FGG) and genes associated with changes in the immune characteristics of a tumor (ENAM, IGFBP1, IL6). In addition, an association of hub genes of poor survival ccRCC subtype with the levels of infiltration of endothelial cells, hematopoietic stem cells, T cells NK and mast cells was revealed. It was shown that MFI2, CP, FGA, and FGG expression can predict the response to sunitinib, while the APOB, ENAM, IGFBP1, and MFI2 expression predict the response to nivolumab. The results obtained provide insight into the genetic characteristics underlying the aggressive subtype of ccRCC and may help develop new approaches to the treatment of this disease.
Вохминцев И. В., Вестник международных организаций: образование, наука, новая экономика 2026 Т. 21 № 2
The EAEU and the CSTO are Russia’s principal regional international organisations. Understanding, assessing, and analysing the foreign-policy positions of the countries that belong to them is a matter of the state’s national interests. This determines the purpose of the study: to identify the level and the form of cohesion in the voting of EAEU and ...
Added: September 7, 2026
Alshanskaia E., Portnova G., Liaukovich K. et al., Frontiers in Neuroscience 2024 Vol. 18
Added: September 7, 2026
Зуенко Д. О., Trofimova E., Хайдарова И., IEEE Access 2026 Vol. 14 P. 121339–121357
Oil spill segmentation in Synthetic Aperture Radar (SAR) images is limited by noisy annotations in publicly available datasets and by architectural choices that interact with label quality in opposing directions. First, we introduce a manually refined version of the Deep-SAR Oil Spill (SOS) dataset, in which 36.25% of masks are corrected for false positives, missed ...
Added: September 7, 2026
Неверов В. Д., Красавин А. В., Vagov A. et al., Physical Review B: Condensed Matter and Materials Physics 2026 Vol. 113 P. 1–6
We develop a neural network approach to solve the self-consistent Bogoliubov-de Gennes equations in strongly disordered s-wave superconductors. The method accurately reproduces inhomogeneous gap distributions and generalizes to system sizes far larger than those used in training. It reduces computational scaling from O(N6 ) to O(N2), enabling quantitative analysis of percolation phenomena and the superconductor-insulator ...
Added: September 5, 2026
Sheshukova M., Durmus A., Khusainov M. et al., Statistics 2026 P. 1–25
In this paper, we consider the problem of Gaussian approximation for the online linear regression task. We derive the corresponding rates for the setting of a constant stepsize and study the explicit dependence of the convergence rate on the problem dimension d and quantities related to the design matrix. When the number of iterations n is known in advance, ...
Added: September 4, 2026
Proceedings of Machine Learning Research , 2026.
Added: September 4, 2026
Khodadoust J., Kulikova S., Khodadoust F., Biomedical Signal Processing and Control 2027 Vol. 129 P. 111284–111284
Acute ischemic stroke (AIS) analysis from two-dimensional (2D) clinical imaging is hindered by uncontrolled slice tilt and geometric inconsistencies that violate the assumptions of pose-agnostic deep learning (DL) models. This paper proposes a unified geometry-aware, frequency-domain framework for tilted slice localization and ischemic stroke segmentation that explicitly decouples pose estimation from lesion analysis. The method ...
Added: September 2, 2026
IEEE, 2026.
On behalf of the Organizing Committee, it is my great pleasure to extend a warm
welcome to all participants of the Fourth International IEEE Conference on
Distributed Computing and High-Performance Computing (DCHPC 2026), held
in Tehran from May 10–11, 2026. This conference is jointly organized by the
School of Computer Science at the Institute for Research in Fundamental
Sciences (IPM) ...
Added: September 2, 2026
Avdoshin S.M., Patrushev K. A., Proceedings of the Institute for System Programming of the RAS 2026 No. 4 часть 2 P. 245–256
The cardinality-constrained Markowitz problem is NP-hard and traditionally solved with commercial MIQP solvers. Following the 2022 export restrictions that rendered both commercial MIQP software and cloud quantum platforms (IBM Quantum, D-Wave Leap) inaccessible from the Russian Federation, practitioners require open-source alternatives. This paper systematically compares three solver families for the discrete mean-variance problem: two open-source ...
Added: August 27, 2026
Zaikin A., Vlasenko D., Zakharov D. et al., Diagnostics 2026 Vol. 16 No. 17 P. 1–15
Background/Objectives: Synolitic graphs (SGs) were developed for task-based fMRI, where
edge weights encode the discriminative power of pairwise regional features; whether similar
information can be recovered from resting-state data was untested. We benchmarked
SGs for autism spectrum disorder (ASD) classification using the multisite ABIDE-I dataset
(871 subjects: 403 subjects with ASD, 468 typical controls; 17 sites; CC200 atlas). Methods:
Using ...
Added: August 27, 2026
Тула: Тульский государственный педагогический университет им. Л.Н. Толстого, 2025.
Сборник содержит материалы, представленные на XXIV Международной конференции «Алгебра, теория чисел, дискретная геометрия и многомасштабное моделирование: современные проблемы, приложения и проблемы истории», посвящённой 110-летию со дня рождения академика Юрия Владимировича Линника и 110-летию со дня рождения профессора Андрея Борисовича Шидловского и 80-летию со дня рождения профессора Геннадия Ивановича Архипова. Материалы конференции будут полезны научным работникам, ...
Added: August 27, 2026
Eduard Sopin, Nazarin A., Begishev V. et al., IEEE Transactions on Vehicular Technology 2026 Vol. 75 No. 6 P. 10995–11007
Aimed at rate-greedy applications having extreme requirements for the data rate at the air interface, 5G New Radio (NR) systems may experience problems when the number of user equipment (UE) in the coverage of the cell increases due to limited capacity of the physical downlink control channel (PDCCH).The aim of this study is to explore ...
Added: August 26, 2026
Джонов А. Т., Avdoshin S. M., Информационные технологии 2026 Т. 32 № 8 С. 421–427
This systematic review presents an analysis of the "Vibe Coding" methodology — a contemporary approach to the iterative software development process using Large Language Models (LLMs). Code generation tools are transforming software development by enabling programmers to formulate tasks and describe the desired behavior of software in natural language, while LLMs generate source code corresponding ...
Added: August 25, 2026
Melman A., Evsyutin O., Journal of the Franklin Institute 2026 Vol. 363 No. 15 Article 109005
Open access to images creates opportunities for violation of the authors' rights. Digital watermarks can be used to securely publish images online. They are invisibly added into the images before publication and can be extracted at any time to verify ownership. However, achieving a balance between embedding imperceptibility and robustness to image processing operations is ...
Added: August 25, 2026
IEEE, 2026.
It is with great pleasure that we welcome all the participants of the 12th Conference on Control, Decision and Information Technologies (CoDIT 2026) at the Polytechnic University of Bari – Orabona Street 4, 70125 Bari, Italy, July 13-16, 2026. CoDIT has grown to become one of the largest conferences organized in Europe and in the ...
Added: August 24, 2026
Лукьяненко Д. В., Ragimova A., Мухорина А. et al., European Physical Journal: Special Topics 2026 P. 1–24
Electronic health records (EHRs) contain vast volumes of clinical information that encode complex relationships between diseases. Traditional approaches to the analysis of interrelated or co-occurring diseases have focused on pairwise associations between diagnoses, missing the higher-order structures that characterise multimorbid patients. The present paper offers a narrative review of existing statistical, machine-learning, and artificial intelligence ...
Added: August 20, 2026
CEUR-WS.org, 2026.
The second edition of the Generative Code Intelligence Workshop (GeCoIn 2026) was held in conjunction with the 35th International Joint Conference on Artificial Intelligence (IJCAI-ECAI 2026), in Bremen, Germany, August 16, 2026. The workshop arose from the desire to bring together a research community that has, in recent years, witnessed rapid progress in the application ...
Added: August 20, 2026
Ryumina E., Aksenov A., Koryakovskaya D. et al., IEEE Access 2026 Vol. 14 P. 124759–124778
Psychological characteristic estimation from multimodal in-the-wild behavior is usually studied using separate corpora, each annotated for a single target task. Such annotation fragmentation limits cross-task learning and cross-domain generalization across affective, dispositional, and interactional phenomena. To address this problem, we use emotion, apparent personality trait, and ambivalence recognition as representative tasks and introduce MM-PSYCHE, a ...
Added: August 20, 2026
Beknazarov N., , in: Parallel Computational Technologies, 19th International Conference, PCT 2025, Moscow, Russia, April 8–10, 2025, Revised Selected Papers. (CCIS, volume 2891)Vol. 2891.: Springer, 2026. P. 3–16.
This paper addresses the challenge of efficiently training Large Language Models (LLMs) on large-scale, sparse omics datasets in high-performance computing (HPC) environments. Using over 1000 BED tracks as a representative data source, we propose a method combining interval-based chunked storage, sparse matrix transformation, and parallel data loading, integrated within a PyTorch Lightning training framework. Our ...
Added: May 19, 2026
Arteaga Moreano B. D., Chervov N., Poptsova M., Scientific Reports 2026 Vol. 16 No. 1 Article 4772
Accurate prediction of protein-protein interactions (PPIs) is fundamental to understanding biological processes and disease mechanisms. While deep learning offers a powerful alternative to costly experimental methods, existing approaches often overlook critical protein-surface information and rely on simplistic feature fusion techniques, thereby limiting performance. To address this, we introduce GSMFormer-PPI, a novel multimodal framework that integrates ...
Added: February 4, 2026
David Arteaga, Poptsova M., Computational and Structural Biotechnology Journal 2026 Vol. 31 P. 82–93
Accurate predictions and large-scale identification of protein-protein interactions (PPIs) are crucial for understanding their inherent biological mechanisms and protein functions in virtually all biological processes. Nowadays, graph-based deep learning models have made significant contributions in modeling proteins with physicochemical and geometric features. However, most of these models rely on conventional graph construction methods, such as ...
Added: December 22, 2025
Budkina A., Korneenko E., Kotov I. et al., Viruses 2021 No. 10 P. 2006
According to various estimates, only a small percentage of existing viruses have been discovered, naturally much less being represented in the genomic databases. High-throughput sequencing technologies develop rapidly, empowering large-scale screening of various biological samples for the presence of pathogen-associated nucleotide sequences, but many organisms are yet to be attributed specific loci for identification. This ...
Added: September 19, 2025
KUDRYAVTSEVA A., Cancers 2023
Liver metastasis is a significant factor contributing to mortality associated with colorectal cancer. Establishing the biological mechanisms of metastasis is crucial for refining diagnostics and identifying therapeutic windows for interventions. Currently, little is known of the processes that govern the development of liver metastases, the role of the tumor microenvironment, the role of epigenetics, and ...
Added: July 1, 2025
Аксенова А. Ю., Жук А. С., Степченкова Е. И. et al., Экологическая генетика 2025 Т. 23 № 2 С. 1–14
Биоинформатика — это быстро развивающаяся дисциплина на стыке биологии, информатики и математики. Научно-технический прогресс в области биологических и биомедицинских наук за последние годы привел к стремительному росту объемов данных. Для анализа и интерпретации больших данных нужны мощные вычислительные инструменты и специалисты с глубокими знаниями в различных областях, включая молекулярную биологию, генетику, программирование и математику. В ...
Added: May 20, 2025