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July 13, 2026
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Researchers at the International Laboratory of Microphysiological Systems of the HSE Faculty of Biology and Biotechnology investigated how different isoforms of the same microRNA influence gene function in prostate adenocarcinoma. The study found that in some cases, microRNAs can reinforce each other’s effects by targeting and suppressing the same genes. This finding offers a fresh perspective on the molecular mechanisms underlying tumour development and on the search for disease biomarkers. The results have been published in PeerJ.
July 13, 2026
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?

New measure of defensive and constructive optimism towards COVID-19 pandemic

European Psychiatry. 2021. Vol. 64. No. 4. P. 283–283.
Gordeeva T. O., Sychev O.

Introduction

Individuals’ beliefs about COVID-19 pandemic may affect their health-related behavior including self-isolation. “Positive” beliefs may be realistic (constructive belief that efforts help to prevent infection and spread of the virus) or rose-colored glasses (defensive belief that coronavirus problem is exaggerated aimed to cope with anxiety) with different consequences for behavior and mental health.

Objectives

Objectives: The aim was to develop the scales of defensive and constructive optimism towards COVID-19 pandemic (DCO-Covid) and analyze their psychometric properties, factor structure using CFA, internal consistency and validity.

Methods

The sample comprised 1403 university students (68% women, M=20.59, SD=3.66) from large cities of Russia. Online survey conducted from 10/4/2020 till 25/4/2020. Test battery included the scales of constructive and defensive optimism (each of 3 items) and measure of dispositional optimism (LOT-R, Scheier et al., 1994). Part of the sample (N=306) completed anxiety in a pandemic questionnaire (Tkhostov, Rasskazova, 2020).

Results

CFA indicated a good fit for the two-factor model (χ2=27.11, df=8, p<.001, CFI =.985, TLI=.971, RMSEA = .041, p[RMSEA≤.05] = .78) with negative correlations between factors (–.28). Cronbach’s alpha for defensive optimism and constructive optimism were α=.75 and α=.70 respectively. As expected constructive and defensive optimism correlated with dispositional optimism (r=.24; p < .001 and r=–.06; p<.05 respectively) and anxiety (fear of infection, r=.08; n.s and r= –.23; p < .001).

Conclusions

The results show that DCO-C is a reliable measure of defensive and constructive optimism towards COVID-19 pandemic. The construct validity of these scales is confirmed by CFA and obtained correlations.

Research target: Psychology
Language: English
DOI
Text on another site
Keywords: COVID-19 pandemicdefensive optimismconstructive optimism
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