Tumour-like Druggable Gene Expression Pattern of CaCo2 Cells in Microfluidic Chip
Biochip Journal. 2016. Vol. 10. No. 3. P. 215-220.
Biochip Journal 2016 Vol. 10 No. 3 P. 215-220
The human-on-chip technology provides an efficient basis for preclinical studies and has potentially a greater predictive power for human drug response than classical 2D cell culture. Here we report the expression profile of druggable genes in the human colon cancer cells CaCo2 in static culture and within a microfluidic chip. We identified gene expression pattern ...
Added: September 11, 2016
Biochip Journal 2017 No. 11 P. 262-269
Added: November 19, 2020
Towards embedding Caco-2 model of gut interface in a microfluidic device to enable multi-organ models for systems biology
BMC Systems Biology 2019 Vol. 13 No. 19 P. 3-11
A cancer cell line originating from human epithelial colorectal adenocarcinoma (Caco-2 cells) serves as a high capacity model for a preclinical screening of drugs. Recent need for incorporating barrier tissue into multi-organ chips calls for inclusion of Caco-2 cells into microperfused environment. This article describes a series of systems biology insights obtained from comparing Caco-2 models ...
Added: October 30, 2018