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  • Поиск связи носительства различных вариантов гена СОМТ c проявлением некоторых черт личности и успешностью в бизнесе

Article

Поиск связи носительства различных вариантов гена СОМТ c проявлением некоторых черт личности и успешностью в бизнесе

Патогенез. 2017. Т. 15. № 4. С. 62-68.
Богданенко Е., Власов А. В., Нурбеков М.

In recent time, differences in manifestations of some personality traits have been associated with single nucleotide substitutions in genes, polymorphisms. Specifically, the Met/Met genotype of Val158Met polymorphisms in the catechol-O-methyltransferase (COMT) gene is associated with higher ability to learn and be satisfied with life and reduced ability to cope with stress and anxiety as compared with the Val/Val genotype. Therefore, carriage of a certain genotype might influence success of a person in his/her activity. To test this hypothesis, 91 people success fully engaged in the same kind of activity, business, underwent psychological and genetic tests. The Mini-Mult (MMPI), TAS-20, and SWLS psychological tests did not detect any significant differences between Val/Val and Val/Met genotype carriers in levels of anxiety and difficulties in interpersonal communication, ability to express their feelings, and life satisfaction. However, the differences between the Val/Val and Met/Met genotype frequencies in businessmen and other populations (1.5 times higher and 25 times lower, respectively) suggested that a successful career in business might be related with a definite genotype. Significant life success as a beneficial environmental factor might neutralize via epigenetic regulation manifestations of congenital depressive personality traints associated with the Val/Val genotype.