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Ламинины и метастазирование опухолей
Молекулярная биология. 2018. Т. 52. № 3. С. 411–434.
Laminins are a family of extracellular heterotrimeric glycoproteins that are the main structural component of basement membranes (BMs), perform a barrier function, and are important for adhesion, dif- ferentiation, migration, and resistance to apoptosis of various cells, including cancer cells. The review sum- marizes the current knowledge of how laminins produced by cancer and normal cells inf luence the key stages of carcinogenesis. Laminin 332 (LN-332) and LN-111 enhance proliferation of certain cancer cells and increase the tumour growth. LN-111 increases resistance to apoptosis, induces differentiation, and inhibits the epithelial–mesenchymal transition (EMT) of cancer cells. LN-332 is associated with higher adhesion and higher migration potential of cancer cells. LN-411 and LN-421 significantly increase motility of cancer cells. LN-332 and LN-511 facilitate cell–cell adhesion and affect the efficacy of cell–cell interactions. The laminin chains α4 and α5 are important for the development and function of blood and lymphatic vessels. The expres- sion ratio of the α4 and α5 laminin chains defines the BM permeability to leukocytes and, presumably, cancer cells in blood and lymphatic vessels. Interactions between LN-511 and α2-containing laminins enhance self- renewal and survival of circulating cancer stem cells. Moreover, laminins are involved in the formation of premetastatic niches and new colonies. Endogenous expression of the α4 laminin chain stimulates prolifera- tion of individualised circulating cancer cells in vitro and in vivo and facilitates micrometastasis.
Keywords: эпителиально-мезенхимальная трансформация lamininsMetastasisметастазированиеlaminin receptorstumor growthinvasionextravasationlymphatic metastasispremetastatic niche formationepithelial–mesenchymal transitionламининырецепторы ламининоврост опухолиинвазияэкстравазациялимфогенное метастазированиеформирование преметастатических ниш
Kashevnik A., Glekler E., Artemenko E. et al., Scientific data 2026 Article 7209
We present a multimodal dataset containing electroencephalography (EEG), electrocardiography (ECG), and video recordings from 49 participants. Each participant completed a single session lasting approximately 45 minutes. During each session they performed five tasks: resting state, inward concentration (focusing on the center of the forehead), outward concentration (visual search), and mind-wandering. EEG data were recorded from ...
Added: April 23, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
G.V.Klink, Gulov D. M., Elumeeva T. G. et al., Журнал общей биологии 2024 Т. 85 № 2 С. 83–94
Plant functional traits are important for the formation of plant communities and for the ability of plants to dominate there. The comparison of mean trait values of organisms within community with that for the random samples of the local biota allows estimating the importance of the trait for the formation of the community composition. The ...
Added: April 19, 2026
G.V.Klink, Semenkov I. N., Enchilik P. R., Science of the Total Environment 2025 Vol. 998 Article 180219
Natural regeneration of forest soils affected by agricultural practices is a common phenomenon in many regions worldwide, particularly in boreal ecosystems. Affecting soil quality, the partitioning of extractable fractions of heavy metals and metalloids (HMMs) is not studied during natural regeneration. The following stages of natural regeneration after plowing have been identified in the Smolenskoye ...
Added: April 19, 2026
Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026
Introduction:
While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception).
Methods:
In 15 healthy adults, motor-evoked potentials (MEPs) were ...
Added: April 17, 2026
Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 P. 48544–48557
Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...
Added: April 15, 2026
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Pogodaeva S., Miletina O., Antipova N. et al., Cancers 2025 Vol. 17 No. 19 Article 3228
Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcriptional burden’, surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to form ...
Added: April 15, 2026
Chernov K., Savin A., Otvodnikova D. et al., Oncology Research 2026 Vol. - No. -
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Kochetkova E., Мачинская Р. И., Журнал высшей нервной деятельности им. И.П. Павлова 2025 Т. 75 № 2 С. 170–188
The review provides an analysis of modern cognitive psychological theories of emotions and neural basis
of mechanisms standing behind retention of emotional information in working memory. The tendency seen
in modern neurocognitive theories is characterized by the rejection of localization for any psychological
functions in favor of network models, where higher-order processes are supported by distributed neural
networks connecting ...
Added: April 15, 2026
Chernov K. V., Savin A. M., Otvodnikova D. E. et al., Oncology Research 2026 Vol. 34 No. 5 P. 1–40
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Kochetkova E., Machinskaya R., Human Physiology 2025 Vol. 51 No. 6 P. 580–590
Growing evidence suggests the specific systems for emotional information maintenance and processing in working memory, highlighting the role of cognitive domains in emotional awareness. The question of neural basis of social-emotional processing in working memory remains open. We hypothesized that the neural systems supporting working memory for emotional processing may rely on shared ‘core’ networks ...
Added: April 15, 2026
Barskaya E. S., Savin A. M., Chernov K. V. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 6 Article 2800
Copper–organic compounds are being investigated as antitumor candidates. Besides their efficacy as cytotoxic agents alone, the oxidative potential of electrochemical Cu2+-to-Cu1+ transition emerges as an attractive approach for elimination of tumor cells otherwise resistant to chemotherapy. To minimize side effects of the potent oxidative burst upon Cu(II) reduction, the metal cations should be delivered to the ...
Added: April 15, 2026
S. V. Nikulin, Olkhovik D., A.V. Razumovskaya et al., Doklady Biochemistry and Biophysics 2026
A novel trend in anticancer therapy is based on the combination of cytotoxic and metabolic drugs. Bach1 is a transcription factor activating glycolysis and increasing proliferation and metastatic potential in cancer cells. The cytotoxic effect was evaluated for a combination of rotenone, an inhibitor of mitochondrial respiration, and two different inhibitors of Bach1 transcription factor ...
Added: April 13, 2026
Everest-Dass A., Nersisyan S., Maar H. et al., Molecular Oncology 2024 Vol. 18 No. 1 P. 62–90
Hematogenous metastasis limits the survival of colorectal cancer (CRC) patients. Here, we illuminated the roles of CD44 isoforms in this process. Isoforms 3 and 4 were predominantly expressed in CRC patients. CD44 isoform 4 indicated poor outcome and correlated with epithelial-mesenchymal transition (EMT) and decreased oxidative phosphorylation in patients; opposite associations were found for isoform 3. Pan-CD44 ...
Added: November 1, 2023
Shelov-Kovedyaev F. V., Stratum Plus 2020 № 6 С. 203–211
The paper publishes some new and summarizes earlier known evidences demonstrating the presence of the Sarmatians in the North Black Sea Region and Crimea in the 3rd cent. B. C. The new evidence includes: the Attic black lacquer plate from the excavations on acropolis of Panticapaeum with a spell against the Sarmatians cast as late ...
Added: October 27, 2022
Brovkina O., Пронина И. В., Бурденный А. М. et al., Бюллетень экспериментальной биологии и медицины 2021 Т. 172 № 12 С. 764–768
Late diagnosis of ovarian cancer is one of the most important problems in its treatment. Long noncoding RNAs (lncRNAs) are poorly studied, nevertheless they are promising as diagnostic biomarkers. In the current study, the interactome of lncRNA was studied to identify biomarkers with potential significance for molecular diagnostics of ovarian cancer. By screening the TCGA ...
Added: June 20, 2022
Arnold S., Cortland J., Maltseva D. et al., Journal of Cancer Research and Clinical Oncology 2021 Vol. 148 No. 6 P. 1525–1542
Purpose:
The transcription factor Fra-2 affects the invasive potential of breast cancer cells by dysregulating adhesion molecules in vitro. Previous results suggested that it upregulates the expression of E- and P-selectin ligands. Such selectin ligands are important members of the leukocyte adhesion cascade, which govern the adhesion and transmigration of cancer cells into the stroma of ...
Added: October 23, 2021
Shkurnikov M., Nikulin S., Nersisyan S. et al., Frontiers in Molecular Biosciences 2019 Vol. 6 No. 122 P. 1–7
Specificity of RNAi to selected target is challenged by off-target effects, both canonical and non-canonical. Notably, more than half of all human microRNAs are co-expressed with hosting them proteincoding genes. Here we dissect regulatory subnetwork centered on IGFBP6 gene, which is associated with low proliferative state and high migratory activity of basal-like breast cancer. We ...
Added: April 28, 2020
Maltseva D., Tonevitsky A., Britisch of Journal Cancer 2014 Vol. 110 No. 3 P. 753–763
Background:
C-Fos was initially described as oncogene, but was associated with favourable prognosis in ovarian cancer (OvCa) patients. The molecular and functional aspects underlying this effect are still unknown.
Methods:
Using stable transfectants of SKOV3 and OVCAR8 cells, proliferation, migration, invasion and apoptotic potential of c-FOS-overexpressing clones and controls were compared. Adherence to components of the extracellular matrix ...
Added: April 16, 2020
Tonevitsky A., Maltseva D., Biochimie 2017 Vol. 142 P. 197–206
Purpose: Ovarian cancer (OvCa) progression mainly takes place by intraperitoneal spread. Adhesion of tumor cells to the mesothelial cells which form the inner surface of the peritoneum is a crucial step in this process. Cancer cells use in principle different molecules of the leukocyte adhesion cascade to facilitate adhesion. This cascade is initiated by selectin-ligand interactions ...
Added: April 16, 2020
Мальцева Д. В., Макарова Ю. А., Хритиченко А. Ю. et al., Молекулярная биология 2019 Т. 53 № 2 С. 330–338
The necessary stage of epithelial-mesenchymal transformation (EMT) is the loss of apical-basal polarization by cells, in the formation of which an important role is played by the interaction of cells with the basement membrane and its laminins. The effect of the transition of colorectal cancer cell lines from the polarized state (2D) to the absence ...
Added: December 13, 2018