Absolute and relative reliability of TMS motor mapping – how much could we trust the results of TMS somatotopy?
In practical medicine, a diagnostic procedure is used only when it can be interpreted at the individual level. The aim of this work was to systematically investigate the relative and absolute reliability of different TMS motor maps parameters. 18 young healthy male right-handed volunteers were enrolled. Two TMS motor mapping sessions of three right-hand muscles were separated by 6-10 days. The analysis was performed using TMSmap software (http://tmsmap.ru). For reliability assessment, intra-class correlation coefficient (ICC) and smallest detectable changes (SDC) were calculated, while for quantitative comparison of the excitability profiles we used a novel earth mover's distance metrics (EMD), the convergence of the parameters depending on the number of stimuli was estimated.