Bioeconomy global trends in agriculture and food safety
Globalization is characterized not only by economic growth and prosperity but also by increasing pressure on natural resources, unsustainable patterns of consumption and production and increasing inequality. To study these global challenges and their impact on development processes authors identified modern trends in the field of bioeconomy and biotechnology developments, analyzed the main government programs, strategies, funds and statistical information from open sources. The basic principles of bioeconomy methods in agro, food and food security in European countries and in Russian Federation were determined and Genetic engineered organisms statistic, policy and public attitudes from open sources in Russia and European countries were compared
In the article the legal problems of safety of the products created by means of use of new grades of plants, containing GMOs are considered. The suggessions concerning some legal ways of strengthening of a guarantee of safety of health of the population of Russia are made.
The paper discusses the general problems of legal regulation on products containing genetically modified organisms. The author also analyzes existing international and Russian legal instruments regulating this field, reveals differences between the legal concepts of "environmental information" and "information about the usage of GMOs.
The article argues that the results of modernization are determined by the growth of innovation potential. The success of modernization depends on the coherence of technological, educational and communication strategies.
One of the key advances in genome assembly that has led to a significant improvement in contig lengths has been improved algorithms for utilization of paired reads (mate-pairs). While in most assemblers, mate-pair information is used in a post-processing step, the recently proposed Paired de Bruijn Graph (PDBG) approach incorporates the mate-pair information directly in the assembly graph structure. However, the PDBG approach faces difficulties when the variation in the insert sizes is high. To address this problem, we first transform mate-pairs into edge-pair histograms that allow one to better estimate the distance between edges in the assembly graph that represent regions linked by multiple mate-pairs. Further, we combine the ideas of mate-pair transformation and PDBGs to construct new data structures for genome assembly: pathsets and pathset graphs.
Many environmental stimuli present a quasi-rhythmic structure at different timescales that the brain needs to decompose and integrate. Cortical oscillations have been proposed as instruments of sensory de-multiplexing, i.e., the parallel processing of different frequency streams in sensory signals. Yet their causal role in such a process has never been demonstrated. Here, we used a neural microcircuit model to address whether coupled theta–gamma oscillations, as observed in human auditory cortex, could underpin the multiscale sensory analysis of speech. We show that, in continuous speech, theta oscillations can flexibly track the syllabic rhythm and temporally organize the phoneme-level response of gamma neurons into a code that enables syllable identification. The tracking of slow speech fluctuations by theta oscillations, and its coupling to gamma-spiking activity both appeared as critical features for accurate speech encoding. These results demonstrate that cortical oscillations can be a key instrument of speech de-multiplexing, parsing, and encoding.
Papers about natural protection territories
Hypoxia of trophoblast cells is an important regulator of normal development of the placenta. However, some pathological states associated with hypoxia, e.g. preeclampsia, impair the functions of placental cells. Oxyquinoline derivative inhibits HIF-prolyl hydroxylase by stabilizing HIF-1 transcription complex, thus modeling cell response to hypoxia. In human choriocarcinoma cells BeWo b30 (trophoblast model), oxyquinoline increased the expression of a core hypoxia response genes along with up-regulation of NOS3, PDK1, and BNIP3 genes and down-regulation of the PPARGC1B gene. These changes in the expression profile attest to activation of the metabolic cell reprogramming mechanisms aimed at reducing oxygen consumption by enabling the switch from aerobic to anaerobic glucose metabolism and the respective decrease in number of mitochondria. The possibility of practical use of the therapeutic properties of oxyquinoline derivatives is discussed.