Highly informative marker sets consisting of genes with low individual degree of differential expression
Genes with significant differential expression are traditionally used to reveal the genetic background underlying phenotypic differences between cancer cells. We hypothesized that informative marker sets can be obtained by combining genes with a relatively low degree of individual differential expression. We developed a method for construction of highly informative gene combinations aimed at the maximization of the cumulative informative power and identified sets of 2–5 genes efficiently predicting recurrence for ER-positive breast cancer patients. The gene combinations constructed on the basis of microarray data were successfully applied to data acquired by RNA-seq. The developed method provides the basis for the generation of highly efficient prognostic and predictive gene signatures for cancer and other diseases. The identified gene sets can potentially reveal novel essential segments of gene interaction networks and pathways implied in cancer progression.
It is proved that any SOо(1, d)-valued cocycle over an ergodic (probability) measurepreserving automorphism is cohomologous to a cocycle having one of three special forms; the recurrence property of such cocycles is also studied.
The question about possibilities to use Twitter users’ moods to increase accuracy of stock price movement prediction draws attention of many researchers. In this paper we examine the possibility of analyzing Twitter users’ mood to improve accuracy of predictions for Gold and Silver stock market prices. We used a lexicon-based approach to categorize the mood of users expressed in Twitter posts and to analyze 755 million tweets downloaded from February 13, 2013 to September 29, 2013. As forecasting technique, we select Support Vector Machines (SVM), which have shown the best performance. Results of SVM application to prediction the stock market prices for Gold and Silver are discussed.
The paper proves the recurrence of measurable cocycles with values in the subgroup of SL(2, C) of diagonal and skew-diagonal matrices over an ergodic transformation preserving the probability measure.
We propose a new mathematical growth model of primary tumor and primary metastases which may help to improve predicting accuracy of breast cancer process using an original mathematical model referred to CoM-IV and corresponding software. The CoM-IV model and predictive software: a) detect different growth periods of primary tumor and primary metastases; b) make forecast of patient survival; c) have higher average prediction accuracy than the other tools; d) can improve forecasts on survival of BC and facilitate optimisation of diagnostic tests. The CoM-IV enables us, for the first time, to predict the whole natural history of primary tumor and primary metastases growth on each stage (pT1, pT2, pT3, pT4) considering only on primary tumor sizes. Summarising: CoM-IV a) describes correctly primary tumor and primary distant metastases growth of IV (T1-4N0-3M1) stage with (N1-3) or without regional metastases in lymph nodes (N0); b) facilitates the understanding of the appearance period and manifestation of primary metastases.
The series Lecture Notes in Computer Science (LNCS), including its subseries Lecture Notes in Artificial Intelligence (LNAI) and Lecture Notes in Bioinformatics (LNBI), has established itself as a medium for the publication of new developments in computer science and information technology research and teaching - quickly, informally, and at a high level.
The two-volume set LNCS 11508 and 11509 constitutes the refereed proceedings of of the 18th International Conference on Artificial Intelligence and Soft Computing, ICAISC 2019, held in Zakopane, Poland, in June 2019.
The 122 revised full papers presented were carefully reviewed and selected from 333 submissions. The papers included in the first volume are organized in the following five parts: neural networks and their applications; fuzzy systems and their applications; evolutionary algorithms and their applications; pattern classification; artificial intelligence in modeling and simulation.
The papers included in the second volume are organized in the following five parts: computer vision, image and speech analysis; bioinformatics, biometrics, and medical applications; data mining; various problems of artificial intelligence; agent systems, robotics and control.
Development of linguistic technologies and penetration of social media provide powerful possibilities to investigate users’ moods and psychological states of people. In this paper we discussed possibility to improve accuracy of stock market indicators predictions by using data about psychological states of Twitter users. For analysis of psychological states we used lexicon-based approach, which allow us to evaluate presence of eight basic emotions in more than 755 million tweets. The application of Support Vectors Machine and Neural Networks algorithms to predict DJIA and S&P500 indicators are discussed.
Previously, a mathematical model of primary tumor (PT) growth and secondary distant metastasis (sdMTS) growth in breast cancer (BC) (CoMPaS), considering the TNM classification, was presented. Nowadays, the updated model CoMPaS and the corresponding software tool can help to optimize the process of detecting the different diagnostic periods for sdMTSs in BC patients with different tumor subtypes ER/PR/HER2/Ki-67 and the growth rate of the PT and sdMTSs.
PRIMARY THERAPY OF EARLY BREAST CANCER
Evidence, Controversies, Consensus
The present research addresses the phenomenon of recurrence at structural, semantic and metatext levels and aims to analyze its impact on the author’s argumentative line and text identity. The paper focuses on the use of prospective and retrospective iteration that plays a particularly significant role in scholarly literature where an academic text is due to comply with specific regulations and to report on the research results in the most objective way. To achieve the goal academic writers rely on employing a system of concepts typical of a particular science, providing unquestionable arguments and critical approach to convince the readers and win their trust. Scholarly articles related to management studies have been exposed to content analysis methodology and the findings reveal that recurrence as a multifunctional phenomenon is an integral part of narrative since it structures the composition, discloses the author’s intention, supplements well justified reasoning through clarification, interpretation, explanation, accentuation and contributes to text consistency, cohesion and coherence.
A model for organizing cargo transportation between two node stations connected by a railway line which contains a certain number of intermediate stations is considered. The movement of cargo is in one direction. Such a situation may occur, for example, if one of the node stations is located in a region which produce raw material for manufacturing industry located in another region, and there is another node station. The organization of freight traﬃc is performed by means of a number of technologies. These technologies determine the rules for taking on cargo at the initial node station, the rules of interaction between neighboring stations, as well as the rule of distribution of cargo to the ﬁnal node stations. The process of cargo transportation is followed by the set rule of control. For such a model, one must determine possible modes of cargo transportation and describe their properties. This model is described by a ﬁnite-dimensional system of diﬀerential equations with nonlocal linear restrictions. The class of the solution satisfying nonlocal linear restrictions is extremely narrow. It results in the need for the “correct” extension of solutions of a system of diﬀerential equations to a class of quasi-solutions having the distinctive feature of gaps in a countable number of points. It was possible numerically using the Runge–Kutta method of the fourth order to build these quasi-solutions and determine their rate of growth. Let us note that in the technical plan the main complexity consisted in obtaining quasi-solutions satisfying the nonlocal linear restrictions. Furthermore, we investigated the dependence of quasi-solutions and, in particular, sizes of gaps (jumps) of solutions on a number of parameters of the model characterizing a rule of control, technologies for transportation of cargo and intensity of giving of cargo on a node station.