Без выбросов и отходов. Вклад Олимпийских игр – 2012 в устойчивое развитие: уроки для России.
Many environmental stimuli present a quasi-rhythmic structure at different timescales that the brain needs to decompose and integrate. Cortical oscillations have been proposed as instruments of sensory de-multiplexing, i.e., the parallel processing of different frequency streams in sensory signals. Yet their causal role in such a process has never been demonstrated. Here, we used a neural microcircuit model to address whether coupled theta–gamma oscillations, as observed in human auditory cortex, could underpin the multiscale sensory analysis of speech. We show that, in continuous speech, theta oscillations can flexibly track the syllabic rhythm and temporally organize the phoneme-level response of gamma neurons into a code that enables syllable identification. The tracking of slow speech fluctuations by theta oscillations, and its coupling to gamma-spiking activity both appeared as critical features for accurate speech encoding. These results demonstrate that cortical oscillations can be a key instrument of speech de-multiplexing, parsing, and encoding.
The given study is devoted to the issues of searching the ways for adaptation to climate change, mitigation of its impact on the economy and population, as well as to the role of increasing energy efficiency in the economies of some countries of Eastern Europe, Caucasus and Central Asia (EECCA). It also relates to the issues of responding to negative trends and emerging challenges caused by climate change. The Report represents several case studies on the above topics implemented in Moldova, Tadjikistan, Kazakhstan, Azerbaijan and the Russian Federation by the network of regional enviuronmental centres. It also contains consideration of possible methodological approaches and recommendations on addressing the above issues in the EECCA region.
In the past decades Foresight has been significantly developed as a tool for long-term forecasting in the field of power generation and energy efficiency. Such research aims at investigation of the most promising innovation strategies in this area, identifying various (including alternative) ways to achieve technological and market goals with the participation of best qualified experts. Such Foresight method as Roadmapping is widespread in the world practice. It helps to shape complex and interrelated views on prospects of innovation development in specific areas of energy efficiency, it links R&D programmes with creation of technologies and products, as well as their subsequent commercialization. The paper provides an overview of the world Foresight experience aimed at creating vision of the future and building innovation strategies related to energy efficiency. Special attention is paid to the Russian research practice, in particular to different types of Foresight projects implemented by the specialists of State University - Higher School of Economics. The authors describe the results of main projects dedicated to shape the future of energy-efficient technologies and to develop of innovation strategies on their application.
Hypoxia of trophoblast cells is an important regulator of normal development of the placenta. However, some pathological states associated with hypoxia, e.g. preeclampsia, impair the functions of placental cells. Oxyquinoline derivative inhibits HIF-prolyl hydroxylase by stabilizing HIF-1 transcription complex, thus modeling cell response to hypoxia. In human choriocarcinoma cells BeWo b30 (trophoblast model), oxyquinoline increased the expression of a core hypoxia response genes along with up-regulation of NOS3, PDK1, and BNIP3 genes and down-regulation of the PPARGC1B gene. These changes in the expression profile attest to activation of the metabolic cell reprogramming mechanisms aimed at reducing oxygen consumption by enabling the switch from aerobic to anaerobic glucose metabolism and the respective decrease in number of mitochondria. The possibility of practical use of the therapeutic properties of oxyquinoline derivatives is discussed.