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Thiophene-based water-soluble C70 fullerene derivatives as novel antioxidant agents
Chetyrkina M. R., Umriukhin P., Ershova E., Proskurnina E., Sergeeva V., Savinova E., Kostyuk S. E., Kameneva L., Kraevaya O., Bolshakova V., Troshin P., Salimova T., Rodionov I., Kutsev S., Veiko N., Kostyuk S. V.
Chernov K., Savin A., Otvodnikova D. et al., Oncology Research 2026 Vol. - No. -
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Chernov K. V., Savin A. M., Otvodnikova D. E. et al., Oncology Research 2026 Vol. 34 No. 5 P. 1–40
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Margarita Chetyrkina, Umriukhin P., Ershova E. et al., Biomaterials Translational 2025 Vol. 6 No. 3 P. 359–370
Fullerenes are one of the most popular nanomaterials, and C70 fullerene is the second most common fullerene after C60 buckminsterfullerene. Minor modification of fullerenes derivatives can change their biological effects and antioxidant properties. A plethora of water-soluble derivatives can be synthesised based on buckminsterfullerenes. In the present study, we synthesised three water-soluble C70 fullerene derivatives ...
Added: February 12, 2026
Ероховец Н. Ю., Вестник Московского университета. Серия 1: Математика. Механика 2021 № 2 С. 61–72
The paper is a review of the results of the eponymous cycle of author's works marked by the I. I. Shuvalov I degree prize 2018 for scientific research and recent results. We study families of three-dimensional simple polytopes defined by the condition of cyclic k-edge-connectivity, in particular, flag polytopes and Pogorelov polytopes, as well as related families of ...
Added: November 26, 2025
Балакина А. А., Приходченко Т. Р., Якушев И. А. et al., Известия Академии наук. Серия химическая 2023 Т. 72 № 7 С. 1618–1632
The structure of 3-hydroxy-6-methyl-2-ethylpyridinium nitroxysuccinate (2), its cytotoxicity, and its ability to influence the content of intracellular nitrogen monoxide, as well as the formation of reactive oxygen species and lipid peroxidation processes under conditions of induced oxidative stress were studied. It was demonstrated that compound 2 had low cytotoxicity in vitro in both non-cancerous and ...
Added: September 14, 2025
M. R. Yanova, A. P. Zhiyanov, I. D. Antipenko et al., Doklady Biochemistry and Biophysics 2023 Vol. 513 P. 324–327
Gemcitabine monophosphate (dFdCMP), one of the intracellular forms of phosphorylated gemcitabine, determines its antitumor activity. A pharmaco-molecular model for determining relative gemcitabine monophosphate level based on the assessment of the activity of ENT1 and ENT2 channels as well as dCK and CDA enzymes in tumor tissue was developed. Relative gemcitabine monophosphate level is a more ...
Added: January 23, 2025
Krasnov L., Tatarin S., Daniil S. et al., Scientific data 2024 Vol. 11 Article 870
Iridium(III) complexes nowadays became rising stars in various health-related applications. Thus, there is a necessity to assess cytotoxicity of the synthesized molecules against cancer/normal cell lines. In this report, we present a dataset of 2694 experimental cytotoxicity values of 803 iridium complexes against 127 different cell lines. We specify the experimental conditions and provide representation ...
Added: September 16, 2024
Ozerova V., Mumyatov A., Goryachev A. et al., Inorganics 2023 Vol. 11 No. 4 Article 153
Perovskite solar cells (PSCs) with p-i-n architecture attracted particular attention from the research community due to their simple and scalable fabrication at low temperatures. However, the operational stability of p-i-n PSCs has to be improved, which requires the development of advanced charge transport interlayers. Fullerene derivatives such as phenyl-C61-butyric acid methyl ester (PC61BM) are commonly ...
Added: June 19, 2023
Bolshakova V. S., Sinegubova E. O., Esaulkova Y. L. et al., Chinese Journal of Chemistry 2023 Vol. 41 No. 15 P. 1803–1808
Herein, we present a facile synthesis of amide-type water-soluble fullerene derivatives decorated with five residues of amino acids. As compared to the previously developed approaches, the proposed method enables usage of a broad range of amino acids, includ-ing those unstable under Friedel-Crafts reaction conditions. Furthermore, it is fully tolerant to the nature of the sixth ...
Added: June 19, 2023
Razumovskaya A., Nikulin S., Алексеев Б. Я. et al., Биотехнология 2021 Т. 37 № 1 С. 87–94
A comparative study of the toxicity of two unsubstituted calixarenes consisting of 4 and 6 phenolic fragments, as well as their p-sulfated derivatives, was carried out on the HT-29 colorectal adenocarcinoma cells cultured in two-dimensional (2D) and three-dimensional (3D) formats. It was shown that both unsubstituted calixarenes decrease the viability of tumor cells; calix[4]arene and ...
Added: February 22, 2023
Fedorov A., Chelombitko M., Chernyavskij D. et al., Cells 2022 Vol. 11 No. 21 Article 3441
Mitochondria-targeted antioxidants have become promising candidates for the therapy of various pathologies. The mitochondria-targeted antioxidant SkQ1, which is a derivative of plastoquinone, has been successfully used in preclinical studies for the treatment of cardiovascular and renal diseases, and has demonstrated anti-inflammatory activity in a number of inflammatory disease models. The present work aimed to investigate ...
Added: December 10, 2022
Yaroslavov A. A., A. A. Efimova, Krasnikov E. A. et al., International Journal of Biological Macromolecules (Нидерланды) 2021 Vol. 177 P. 455–462
Anionic liposomes were electrostatically adsorbed onto the surface of cationic chitosan particles cross-linked by sulfate anions, forming multi-liposomal containers (MLCs) for encapsulation and delivery of bioactive substances. An increase in molecular mass of chitosan from 30 to 300 kDa results in a size increase of chitosan particles, from 200 to 400 nm. Being saturated by ...
Added: October 5, 2022
Olyanich D. A., Mararov V. V., Utas T. V. et al., Applied Surface Science 2018 Vol. 456 P. 801–807
The Si(111)5×2-Au surface comprises a quasi-one-dimensional surface reconstruction consisting of Au stripes mediated by honeycomb Si chains. In the present study, using STM observations we explored adsorption of thallium (Tl) onto Si(111)5×2-Au surface as well as growth of C60 layers on Tl-modified and intact Si(111)5×2-Au surfaces. Analysis of the results was based on the recently ...
Added: September 15, 2022
V. E. Antonov, Bazhenov A. V., Bashkin I. O. et al., Journal of Surface Investigation: X-Ray, Synchrotron and Neutron Techniques 2020 Vol. 14 No. 5 P. 995–1002
This paper is a brief summary of the results of long-term experimental studies of C60Hx hydrofullerites
with a hydrogen content of up to x ~ 60 or more, obtained by loading C60 fullerites with hydrogen at
pressures up to 9 GPa and temperatures up to 500°C. Basically, this is an overview of already published data.
Some results for ...
Added: November 17, 2021
Massey Products in the Cohomology of the Moment-Angle Manifolds Corresponding to Pogorelov Polytopes
E. G. Zhuravleva, Mathematical notes 2019 Vol. 105 No. 4 P. 519–527
Nontrivial Massey products in the cohomology of the moment-angle manifolds corresponding to polytopes in the Pogorelov class are constructed. This class includes the dodecahedron and all fullerenes, i.e., simple 3-polytopes with only 5- and 6-gonal faces. The existence of nontrivial Massey products implies that the spaces under consideration are not formal in the sense of ...
Added: October 31, 2021
Skvortsov D., Kalinina M., Zhirkina I. et al., Frontiers in Pharmacology 2021 Vol. 12 Article 713103
For the search of anticancer compounds in modern large chemical libraries, new approaches are of great importance. Cocultivation of the cells of tumor and non-tumor etiology may reveal specific action of chemicals on cancer cells and also take into account some effects of the tumor cell’s microenvironment. The fluorescent cell cocultivation test (FCCT) has been ...
Added: October 29, 2021
Victor M. Buchstaber, Nikolay Yu. E., Structural Chemistry 2016 Vol. 28 No. 1 P. 225–234
We study the well-known problem of combinatorial classification of fullerenes. By a (mathematical) fullerene we mean a convex simple three-dimensional polytope with all facets pentagons and hexagons. We analyse approaches of construction of arbitrary fullerene from the dodecahedron (a fullerene C 20). A growth operation is a combinatorial operation that substitutes the patch with more facets and ...
Added: June 17, 2021
Orekhov N. D., Ostroumova G., Stegailov V., Carbon 2020 Vol. 170 P. 606–620
Molecular dynamics with reactive interatomic potentials is the only computationally feasible approach for modeling at the atomistic level the formation of carbon nanoparticles from gas state. Such models require thousands of atoms and millions of time steps that is beyond the current capabilities of first principles electronic structure calculations. A continuously growing variety of available ...
Added: October 31, 2020
Dobrynin A., Vesnin A., Mathematics 2019 Vol. 7 No. 11 P. 1–17
Fullerenes are molecules that can be presented in the form of cage-like polyhedra, consisting only of carbon atoms. Fullerene graphs are mathematical models of fullerene molecules. The transmission of a vertex v of a graph is a local graph invariant defined as the sum of distances from v to all the other vertices. The number ...
Added: October 27, 2020
Titov, IY, Novikov, FN, European Journal of Medicinal Chemistry 2020 Vol. 198 No. 15 P. 112331–112344
TheMDR1/P-glycoprotein (Pgp)/ABCB1 multidrug transporter is being investigated as a druggable targetfor antitumor therapy for decades. The natural product curcumin is known to provide an efficient scaffoldfor compounds capable of blocking Pgp mediated efflux and sensitization of multidrug resistant (MDR)cells to the Pgp transported drug doxorubicin (Dox). We performed molecular dynamics simulations anddocking of curcumin derivatives ...
Added: October 15, 2020
Machulkin A., Skvortsov D., Ivanenkov Y. et al., Bioorganic and Medicinal Chemistry Letters 2019 Vol. 29 No. 16 P. 2229–2235
Prostate cancer (PC) is the second most commonly occurring cancer in men. Conventional chemotherapy has wide variety of disadvantages such as high systemic toxicity and low selectivity. Targeted drug delivery is a promising approach to decrease side effects of therapy. Prostate specific membrane antigen (PSMA) is overexpressed in prostate cancer cells while low level of ...
Added: March 13, 2020