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Наноразмерные системы фолиевая кислота-амфифильный сополимер N-винилпирролидона с метакриловой кислотой, разветвленный диметакрилатом триэтиленгликоля
Известия Академии наук. Серия химическая. 2023. Т. 72. № 6. С. 1349–1365.
Курмаз С. В., Иванова И., Фадеева Н. В., Игнатьев В. М., Емельянова Н. С., Лапшина М. А., Балакина А. А., Terentiev A.
Polymer compositions of folic acid based on an amphiphilic copolymer of N-vinylpyrrolidone with methacrylic acid branched with triethylene glycol dimethacrylate have been developed and characterized by the methods of DLS, 1H NMR, IRS, DSC and TGA in solutions and in solid state. The effective binding constants of folic acid to copolymer in isopropyl alcohol and in aqueous media were determined using electron absorption spectroscopy. The behavior of nanoscale systems in water as a function of the temperature and pH of the medium has been studied, and their hydrodynamic radii have been determined. Quantum chemical modeling of the structure of intermolecular complexes has been performed and it has been shown that hydrogen bonds formed by oxygen atoms of carboxyl groups of either folic acid or a unit of methacrylic acid with hydrogen atoms are weak. The cytotoxicity of polymer compositions with different folic acid content (0.5-4 wt.%) was studied in non-cancerous (FetMSC, Vero) and tumor cells HeLa (human cervical adenocarcinoma, clone M-HeLa) and HepG2 (human liver carcinoma) and it was found that they exhibited high biocompatibility. The dynamics of accumulation of polymer particles loaded with folic acid and fluorescent dye zinc tetraphenylporphyrinate in Vero and HeLa cells has been studied by fluorescence microscopy. The conclusion was made about the prospects of the developed compositions as targeted delivery systems.
Keywords: цитотоксичностьfluorescenceфлуоресценцияfolic acidcytotoxicityфолиевая кислотаN-vinylpyrrolidonetriethylene glycol dimethacrylatequantum chemical modelingN-винилпирролидондиметакрилат триэтиленгликоляквантовохимическое моделированиеmethacrylic acidamphiphilic copolymerscellular accumulationметакриловая кислотаамфифильные сополимерыклеточное накопление
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Ryskina H., Лобаева Т. А., Ануркина А. И., Ваш формат, 2025.
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Эволюция, экология, генетика человека, медицинская паразитология. Практикум. Аннотация
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