• A
  • A
  • A
  • АБВ
  • АБВ
  • АБВ
  • A
  • A
  • A
  • A
  • A
Обычная версия сайта
  • RU
  • EN
  • HSE University
  • Publications
  • Articles
  • A Mathematical Model of in vitro Hepatocellular Cholesterol and Lipoprotein Metabolism for Hyperlipidemia Therapy
  • RU
  • EN
Расширенный поиск
Высшая школа экономики
Национальный исследовательский университет
Priority areas
  • business informatics
  • economics
  • engineering science
  • humanitarian
  • IT and mathematics
  • law
  • management
  • mathematics
  • sociology
  • state and public administration
by year
  • 2028
  • 2027
  • 2026
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007
  • 2006
  • 2005
  • 2004
  • 2003
  • 2002
  • 2001
  • 2000
  • 1999
  • 1998
  • 1997
  • 1996
  • 1995
  • 1994
  • 1993
  • 1992
  • 1991
  • 1990
  • 1989
  • 1988
  • 1987
  • 1986
  • 1985
  • 1984
  • 1983
  • 1982
  • 1981
  • 1980
  • 1979
  • 1978
  • 1977
  • 1976
  • 1975
  • 1974
  • 1973
  • 1972
  • 1971
  • 1970
  • 1969
  • 1968
  • 1967
  • 1966
  • 1965
  • 1964
  • 1963
  • 1958
  • More
Subject
News
September 11, 2026
How to Assess Students Knowledge in the Age of AI
A researcher at HSE University has proposed a flowchart to help lecturers decide how to assess students who use artificial intelligence. It shows where the use of AI should be restricted and where it can be incorporated into the learning process. The article has been published in IT Professional.
September 9, 2026
‘Balkan Hospitality Opens Doors: Studying Dialects on the Verge of Extinction
You cannot study spoken dialects from books. Instead, you need to go to a village, seek out its elders, and earn the trust of local residents before you can record hours of spontaneous stories. This is how Natalia Muravleva, Associate Professor at the Faculty of Humanities, conducts her research. Her internship in Serbia continued her long-standing study of dialects spoken by Macedonian settlers. In this interview, she discusses how diaspora cultural centres help researchers reach informants, why native speakers need to be interviewed only in their own language (otherwise, as she puts it, they may 'break'), and how a single field season helped her finalise her monograph. She also shares warm memories of autumn in Belgrade and of colleagues with whom grammar can be discussed in three languages at once.
September 9, 2026
Scientists Train Neural Network to Generate Process Plans from 3D Models
Researchers at the HSE FCS AI and Digital Science Institute have developed CAD2TechSpec, a framework that converts 3D models of mechanical parts into machining process plans—step-by-step instructions for machine tools. The solution aims to reduce the time required for the design and preparation of technical process documentation in mechanical engineering, aircraft manufacturing, and other high-tech industries. The study findings have been published in PeerJ Computer Science.

 

Have you spotted a typo?
Highlight it, click Ctrl+Enter and send us a message. Thank you for your help!

Publications
  • Books
  • Articles
  • Chapters of books
  • Working papers
  • Report a publication
  • Research at HSE

?

A Mathematical Model of in vitro Hepatocellular Cholesterol and Lipoprotein Metabolism for Hyperlipidemia Therapy

Plos One. 2022. Vol. 17. No. 6.
Efremov Y., Ermolaeva A., Vladimirov G., Гордлеева С. Ю., Svistunov A., Zaikin A., Timashev P.

Cardiovascular diseases associated with high cholesterol (hypercholesterolemia) and low-density lipoproteins (LDL) levels are significant contributors to total mortality in developing and developed countries. Mathematical modeling of LDL metabolism is an important step in the development of drugs for hypercholesterolemia. The aim of this work was to develop and to analyze an integrated mathematical model of cholesterol metabolism in liver cells and its interaction with two types of drugs, statins and PCSK9 inhibitors. The model consisted of 21 ordinary differential equations (ODE) describing cholesterol biosynthesis and lipoprotein endocytosis in liver cells in vitro. The model was tested for its ability to mimic known biochemical effects of familial hypercholesterolemia, statin therapy, and PCSK9 inhibitors. The model qualitatively reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in initial testing of new drugs for cardiology.

Research target: Mathematics Biology
Language: English
Full text
DOI
Text on another site
Keywords: mathematical modelcholesterol and lipoprotein metabolismhyperlipidemia
Similar publications
Характеристические алгебры и интегрируемые системы экспоненциального типа
Смирнов С. В., Миллионщиков Д. В., Уфимский математический журнал 2021 Т. 13 № 2 С. 44–73
В данной работе изучаются характеристические алгебры для систем экспоненциального типа, соответствующих вырожденным матрицам Картана. Эти системы обобщают хорошо известные в теории интегрируемых систем гиперболические уравнения синус-Гордон и Цицейки. Для таких систем, соответствующих матрицам Картана ранга 2, характеристические алгебры описаны явно в терминах образующих и соотношений, и доказано, что они имеют линейный рост. Исследуется связь между ...
Added: September 11, 2026
Darboux formulae for linear hyperbolic equations in the discrete case
Смирнов С. В., Glasgow Mathematical Journal 2026 Vol. 68 No. 2 P. 299–316
In the second half of the 19th century Darboux obtained determinant formulae that provide the general solution for a linear hyperbolic second order PDE with finite Laplace series. These formulae played an important role in his study of the theory of surfaces and, in particular, in the theory of conjugate nets. During the last three ...
Added: September 11, 2026
Integral preserving discretization of 2D Toda lattices
Смирнов С. В., Journal of Physics A: Mathematical and Theoretical 2023 Vol. 56 No. 26 Article 265204
There are different methods of discretizing integrable systems. We consider semi-discrete analog of two-dimensional Toda lattices associated to the Cartan matrices of simple Lie algebras that was proposed by Habibullin in 2011. This discretization is based on the notion of Darboux integrability. Generalized Toda lattices are known to be Darboux integrable in the continuous case ...
Added: September 11, 2026
ВЕРОЯТНОСТНЫЕ МОДЕЛИ РАЗМЕЩЕНИЯ ПО ЯЧЕЙКАМ СЛУЧАЙНОГО ЧИСЛА ЧАСТИЦ
Enatskaya N., Труды Карельского научного центра РАН. Серия 10: Математическое моделирование и информационные технологии 2026 № 6 С. 132–138
In schemes S for placing r particles in n distinguishable cells, their placement in selected m cells – schemes S∗ is studied, for which the analysis is carried out by a new enumerative method (EM) in extended areas of enumerative combinatorics: finding the number of outcomes and, based on the construction of a model of ...
Added: September 11, 2026
КОМБИНАТОРНЫЙ АНАЛИЗ СХЕМ РАЗМЕЩЕНИЯ ЧАСТИЦ С ЗАДАННЫМ МАКСИМАЛЬНЫМ УРОВНЕМ ЗАПОЛНЕНИЯ ЯЧЕЕК
Enatskaya N., Труды Карельского научного центра РАН. Серия 10: Математическое моделирование и информационные технологии 2026 № 6 С. 139–147
The class of particle cell arrangements under consideration is characterized by the introduction of an upper limit on the filling levels of the cells, which must be achieved in at least one cell of each outcome of each arrangement. The circuits are distinguished by the paired qualities of their constituent elements (cells and particles) according ...
Added: September 11, 2026
Многокритериальные задачи с упорядоченными по важности группами критериев (II). Решающие правила
Podinovskiy V. V., Нелюбин А. П., Автоматика и телемеханика 2026 № 8 С. 110–123
Для многокритериальных задач принятия решений по аналогии с качественной вероятностью введены понятия полной и частичной качественной важности как бинарных отношений, обладающих постулируемыми свойствами. Предложено новое определение отношения нестрогого предпочтения на множестве вариантов решений, порождаемое качественной важностью. Исследованы его свойства. Указаны аналитические правила, позволяющие попарно сравнивать варианты по предпочтительности. Проведено сравнение новых отношений предпочтения с разработанными ранее для задач, ...
Added: September 9, 2026
Теоретические основы и методы анализа решений в условиях неопределенности при качественных оценках вероятностей и предпочтений
Podinovskiy V. V., Нелюбин А. П., Автоматика и телемеханика 2026 № 7 С. 113–126
Рассматриваются задачи принятия решений, когда предпочтения оцениваются в порядковой шкале, а возможности реализации значений неопределенного фактора описываются качественной вероятностью (полной или только частичной). Вводятся определения отношений предпочтения и безразличий на множестве стратегий. Предлагаются простые решающие правила, позволяющие сравнивать стратегии по предпочтительности, и приводятся иллюстративные примеры. ...
Added: September 9, 2026
Degree-based topological co-indices for QSPR modelling of benzenoid hydrocarbons: a comparative computational study
Chemical Papers 2026
Benzenoid hydrocarbons are structurally regular aromatic compounds, which makes them well suited for quantitative structure–property relationship (QSPR) studies. This study presents a QSPR analysis of nineteen benzenoid hydrocarbon species using degree-based topological co-indices. We developed a Python program to compute eleven degree-based topological co-indices from molecular graphs and evaluated their ability to explain variations in ...
Added: September 8, 2026
Разработка методик на основе айтрекинга для диагностики когнитивных функций у детей
Ребрейкина А. Б., Liaukovich K., Современная зарубежная психология 2024 Т. 13 № 2 С. 33–43
Создание методик диагностики на основе анализа движений глаз является особенно актуальным для оценки когнитивных функций у детей, которые не могут дать речевой или моторный ответ в силу своего возраста или из-за нарушений развития. Для таких детей использование объективных методов оценки когнитивных функций на основе айтрекинга может стать полезным диагностическим инструментом, дополняющим традиционные поведенческие опросники и ...
Added: September 8, 2026
Развитие когнитивных функций детей с помощью методик, использующих видеоокулографию
Ребрейкина А. Б., Liaukovich K., Современная зарубежная психология 2023 Т. 12 № 4 С. 51–61
Активное развитие метода видеоокулографии, т. е. регистрации движений глаз, создает возможности для создания новых подходов для развития когнитивных функций и обучения. Методики, основанные на видеоокулографии, могут быть полезны не только для детей с серьезными нарушениями моторных функций, но и детей с нарушениями развития когнитивных функций, прежде всего внимания, так как контроль движений глаз тесно связан ...
Added: September 8, 2026
Вегетативные и поведенческие показатели при увеличении когнитивной нагрузки у здоровых добровольцев
Портнова Г. В., Liaukovich K., Васильева Л. Н. et al., Журнал высшей нервной деятельности им. И.П. Павлова 2022 Т. 72 № 4 С. 504–519
Когнитивная и эмоциональная нагрузка в ходе увеличения сложности задач приводит к активации различных звеньев вегетативной нервной системы и может сопровождаться как увеличением эффективности решения задач, так и способствовать дестабилизации эмоционального состояния и уменьшению продуктивности. Увеличение когнитивной нагрузки при условии высокой мотивации испытуемых является стрессовым фактором и выражается в различной реакции симпатического и парасимпатического звеньев в ...
Added: September 8, 2026
On phase-lock area parquet in a special slow-fast limit of model of Josephson junction.
Glutsyuk A., / Series arXiv "math". 2026.
B.Josephson (Nobel Prize, 1973) predicted a tunnelling effect for a system of two superconductors separated by a narrow dielectric (such a system is called Josephson junction): existence of a supercurrent through it and equations governing it. The overdamped Josephson junction is modeled by the family of differential equations on the 2-torus, dθdτ=1ω(cosθ+B+Acosτ), which is known as ...
Added: September 8, 2026
On exotic rationally integrable dual billiards I. Complex geometry and type of dynamics.
Glutsyuk A., / Series arXiv "math". 2026.
A planar dual billiard is a planar curve γ equipped with a family (σP)|P∈γ of projective involutions of the projective lines LP tangent to γ at P that fix P. A dual billiard is called rationally integrable, if there exists a rational function R(x,y) of two variables (called first integral) whose restriction to each tangent ...
Added: September 8, 2026
Dynamical systems on torus related to general Heun equations: phase-lock areas and constriction breaking
Alexandrov A., Glutsyuk A., Journal of Differential Equations 2026 Vol. 465 Article 114178
The overdamped Josephson junction in superconductivity theory can be modeled by the family of dynamical systems on the torus, which is known as the RSJ model. This family admits an equivalent description by a family of second-order differential equations: special double confluent Heun equations. In the present paper, we construct two new families of dynamical systems on ...
Added: September 8, 2026
On rationally integrable planar dual and projective billiards
Glutsyuk A., Inventiones Mathematicae 2026 Vol. 245 P. 977–1058
A caustic of a strictly convex planar bounded billiard is a smooth curve whose tangent lines are reflected from the billiard boundary to its tangent lines. The famous Birkhoff Conjecture, studied by many mathematicians, states that if the billiard boundary has an inner neighborhood foliated by closed caustics, then it is an ellipse. In the paper we study ...
Added: September 8, 2026
Rational p-adic Hodge theory for d-de Rham-proper stacks
Prikhodko Artem, Kubrak D., Compositio Mathematica 2026 Vol. 162 No. 6 P. 1377–1438
In this follow-up paper we show that smooth Hodge-proper stacks over O𝐾 are ℚ𝑝-locally acyclic: namely the natural map between étale ℚ𝑝-cohomology of the algebraic and Raynaud generic fibers is an equivalence. This establishes the ℚ𝑝-case of general conjectures made in D. Kubrak and A. Prikhodko [p-adic Hodge theory for Artin stacks, Mem. Amer. Math. ...
Added: September 7, 2026
Lower Bounds on the Measure of the Support of Positive and Negative Parts of Trigonometric Polynomials
Ismailov A., Constructive Approximation 2026
The measure of the positivity set {x ∈ [0; 2π] | f (x) > 0} of a trigonometric polynomial f  is bounded from below by the Motzkin density. We generalize the bound to polynomials in several variables and almost periodic functions. We then use these generalizations to extend known results on Taikov’s problem. ...
Added: September 7, 2026
DSCA-HLAII: A dual-stream cross-attention model for predicting peptide–HLA class II interaction and presentation
Shaitan A., Ke Y., Hongjun Y. et al., PLoS Computational Biology 2026 Article e1013836
The interaction between peptides and human leukocyte antigen class II (HLA-II) molecules plays a pivotal role in adaptive immune responses, as HLA-II mediates the recognition of exogenous antigens and initiates T cell activation through peptide presentation. Accurate prediction of peptide-HLA-II binding serves as a cornerstone for deciphering cellular immune responses, and is essential for guiding the optimization of antibody therapeutics. ...
Added: September 7, 2026
Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder
Proskurnina E., Liaukovich K., Bychkovskaya L. et al., Metabolites 2023 Vol. 13 No. 1 P. 73
Added: September 7, 2026
Event-Related Potential Study of Recovery of Consciousness during Forced Awakening from Slow-Wave Sleep and Rapid Eye Movement Sleep
Liaukovich K., Sazhin S., Bobrov P. et al., International Journal of Molecular Sciences 2022 Vol. 23 No. 19 P. 11785
Added: September 7, 2026
Implicit auditory perception of local and global irregularities in passive listening condition
Liaukovich K., Ukraintseva Y., Martynova O., Neuropsychologia 2022 Vol. 165 P. 108129
Added: September 7, 2026
Pupillometry and autonomic nervous system responses to cognitive load and false feedback: an unsupervised machine learning approach
Alshanskaia E., Portnova G., Liaukovich K. et al., Frontiers in Neuroscience 2024 Vol. 18
Added: September 7, 2026
Biological and Social Phases of Big History and Complexity Growth
Leonid Grinin, Alexander M., Korotayev A., , in: Complexity in Universal Evolution. A Big History Perspective.: Springer, 2026. Ch. 12 P. 283–355.
In the first half of this chapter, Grinin et al. survey general similarities and differences between biological and social macroevolution. They undertake a systematic comparison between biological and social evolution at different levels of analysis and in various aspects, formulating a considerable number of general principles and rules of evolution, and working to develop a ...
Added: August 10, 2026
ИССЛЕДОВАНИЕ АССОЦИАЦИИ ГЕНЕТИЧЕСКИХ ВАРИАНТОВ С РАЗВИТИЕМ МУЗЫКАЛЬНЫХ СПОСОБНОСТЕЙ ЧЕЛОВЕКА
Kazantseva A. V., A.V. Toropova, Khusnutdinova E. K. et al., ВАВИЛОВСКИЙ ЖУРНАЛ ГЕНЕТИКИ И СЕЛЕКЦИИ, Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук» (ИЦиГ СО РАН) (Новосибирск) 2025 Vol. 30 No. 3 P. 470–481
The development of musical abilities, including absolute pitch, musical memory, rhythm sense, and musicality, at a high degree is determined by a hereditary component (up to 68 %). The studies implementing a genome-wide linkage and association approach to musical aptitude have revealed more than 100 genetic loci. This spectrum is comprised of the genes encoding ...
Added: May 29, 2026
  • About
  • About
  • Key Figures & Facts
  • Sustainability at HSE University
  • Faculties & Departments
  • International Partnerships
  • Faculty & Staff
  • HSE Buildings
  • HSE University for Persons with Disabilities
  • Public Enquiries
  • Studies
  • Admissions
  • Programme Catalogue
  • Undergraduate
  • Graduate
  • Exchange Programmes
  • Summer University
  • Summer Schools
  • Semester in Moscow
  • Business Internship
  • Research
  • International Laboratories
  • Research Centres
  • Research Projects
  • Monitoring Studies
  • Conferences & Seminars
  • Academic Jobs
  • Yasin (April) International Academic Conference on Economic and Social Development
  • Media & Resources
  • Publications by staff
  • HSE Journals
  • Publishing House
  • iq.hse.ru: commentary by HSE experts
  • Library
  • Economic & Social Data Archive
  • Video
  • HSE Repository of Socio-Economic Information
  • HSE1993–2026
  • Contacts
  • Copyright
  • Privacy Policy
  • Site Map
Edit