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October 14, 2026
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Genome-wide association study of depression symptoms using online self-questionnaires in the Russian population cohort: preliminary results

European Psychiatry. 2022. Vol. 65. No. S1. P. 327–327.
Kibitov A., Rakitko A., Kasyanov E., Yermakovich D., Kibitov A., Rukavishnikov G., Ilinsky V., Golimbet V., Shmukler A., Neznanov N., Mazo G.

Introduction: Depression is a chronic, recurrent mental disorder with a moderate level of genetic impact. Modern GWAS of depression require extra-large sample sizes and new effective, clinically sensitive, objective and simple to fill online phenotyping tools for population studies are necessary today.

Objectives

Aim: to test online phenotyping tools based on clinical and psychometric instruments to evaluate depressive symptoms in population cohort for using in GWAS

Methods

Participants: 2610 Russian-speaking respondents-clients of Genotek Ltd., provider of genetic testing services in Russian Federation. The online survey included HADS-D (Hospital Anxiety and Depression Scale-depression subscale), original questionnaire adapted for self-report from major depression DSM-5 criteria, questions about sex and age. Three research phenotypes were defined: quantitative “HADS-D score” and two categorical “HADS-D depression”(cut-off 8 points)-20.63%,“DSM depression” 16.73%. DNA samples obtained from saliva were genotyped on Illumina Infinium GSA v1. 0/v2. 0/v3. 0 microarrays. GWAS analysis was performed independently for each of the research phenotypes.

Language: English
DOI
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Keywords: depressionGWASphenotyping
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