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Найдено 6 публикаций
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Статья
Smith R. T., Mirkin B., Muchnik I. Journal of Computational Biology. 1995. No. 2(4).
Добавлено: 1 ноября 2010
Статья
Nurk S., Bankevich A., Antipov D. et al. Journal of Computational Biology. 2013. Vol. 20. No. 10. P. 714-737.
Добавлено: 21 марта 2014
Статья
Mirkin B., Eulenstein O., Vingron M. Journal of Computational Biology. 1995. No. 5(1).
Добавлено: 29 октября 2010
Статья
Pham S. K., Antipov D., Sirotkin Alexander et al. Journal of Computational Biology. 2013. Vol. 20. No. 4. P. 359-371.
Добавлено: 21 марта 2014
Статья
Pirogov S., et a., Gelfand M. S. Journal of Computational Biology. 2016. Vol. 23. No. 9. P. 711-717.
Добавлено: 13 марта 2017
Статья
Bankevich A., Nurk S., Antipov D. et al. Journal of Computational Biology. 2012. Vol. 19. No. 5. P. 455-477.

The lion's share of bacteria in various environments cannot be cloned in the laboratory and thus cannot be sequenced using existing technologies. A major goal of single-cell genomics is to complement gene-centric metagenomic data with whole-genome assemblies of uncultivated organisms. Assembly of single-cell data is challenging because of highly non-uniform read coverage as well as elevated levels of sequencing errors and chimeric reads. We describe SPAdes, a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V−SC assembler (specialized for single-cell data) and on popular assemblers Velvet and SoapDeNovo (for multicell data). SPAdes generates single-cell assemblies, providing information about genomes of uncultivatable bacteria that vastly exceeds what may be obtained via traditional metagenomics studies. SPAdes is available online (http://bioinf.spbau.ru/spades). It is distributed as open source software.

Добавлено: 13 февраля 2013