Biochemical basis of skin disease Mal de Meleda: SLURP-1 mutants differently affect keratinocyte proliferation and apoptosis

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Biochemical basis of skin disease Mal de Meleda: SLURP-1 mutants differently affect keratinocyte proliferation and apoptosis

Journal of Investigative Dermatology. 2021. P. 1–9.

Shulepko M., Bychkov M., Shenkarev Z., Kulbatskii D., Makhonin A., Paramonov A., Чугунов А. О., Kirpichnikov M., Lyukmanova E.

Научное направление: Химия Биология

Язык: английский

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Centromeres ensure chromosome segregation, but their chromatin organization within repetitive alpha-satellite DNA has been difficult to resolve. To address this, we generated haplotype-resolved satellite DNA annotations for the complete diploid T2T-HG002 human genome assembly, then we mapped centromere protein A (CENP-A), H3K9me3, and CpG methylation on ultra-long, adaptively sampled nanopore reads using directed methylation with ...

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Three new Hg(II) bromide complexes, HgBr2L (1–3) (L1 = N′-(pyridin-2-ylmethylene)isonicotinohydrazide, L2 = N′-(1-(pyridin-2-yl)ethylidene)isonicotinohydrazide, L3 = N′-(phenyl(pyridin-2-yl)methylene)isonicotinohydrazide), have been synthesized in good yields and thoroughly characterized. Single-crystal X-ray diffraction analyses unveil that complexes 1 and 3 are mononuclear, while complex 2 is dinuclear. All complexes further assemble into one-dimensional supramolecular chains mediated by N–H···N hydrogen bonds, which are reinforced by π···π stacking and Br···Br halogen interactions. Systematic variation ...

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Structural Insight into Specificity of Interactions between Non-conventional Three-Finger Toxin WTX and Muscarinic Acetylcholine Receptors

Lyukmanova E., Shenkarev Z., Shulepko M. и др., Journal of biological chemistry 2015 Vol. 290 P. 23616–23630

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Central loop of non-conventional toxin WTX from Naja kaouthia is important for interaction with nicotinic acetylcholine receptors.

Lyukmanova E., Shulepko M., Shenkarev Z. и др., Toxicon 2016 Vol. 119 P. 274–279

Добавлено: 14 марта 2017 г.

Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors

Lyukmanova E. N., Shulepko M. A., Shenkarev Z. O. и др., Scientific Reports 2016 Vol. 6 No. 30698 P. 1–17

Human-secreted Ly-6/uPAR-related protein-2 (SLURP-2) regulates the growth and differentiation of epithelial cells. Previously, the auto/paracrine activity of SLURP-2 was considered to be mediated via its interaction with the α3β2 subtype of the nicotinic acetylcholine receptors (nAChRs). Here, we describe the structure and pharmacology of a recombinant analogue of SLURP-2. Nuclear magnetic resonance spectroscopy revealed a ...

Добавлено: 6 октября 2016 г.

Central loop of non-conventional toxin WTX from Naja kaouthia is important for interaction with nicotinic acetylcholine receptors

Lyukmanova E. N., Shulepko M. A., Shenkarev Z. O. и др., Toxicon 2016 Vol. 119 No. September P. 274–279

Highlights • Mutagenesis of non-conventional toxin WTX from Naja kaouthia is performed. • Activity of WTX and its mutants on muscle-type and α7-type of nAChRs was studied. • R31 and R32 from the loop II is important for binding to both types of receptors. • Modeling revealed the loop II entering into the orthosteric site of the α7 nAChRs. <hr /> Abstract ‘Three-finger’ toxin WTX from Naja kaouthia interacts with ...

Добавлено: 14 сентября 2016 г.