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Статья

Copper-promoted C-Se Cross-Coupling of 2-selenohydantoins with Arylboronic Acids in an Open Flask

ACS Combinatorial Science. 2019. Vol. 21. No. 6. P. 456-464.
Vyhivskyi O., Dlin E., Finko A., Stepanova S., Ivanenkov Y., Skvortsov Dmitry, Mironov A., Zyk N., Majouga A., Beloglazkina E.

The modification of Chan–Lam–Evans cross-coupling reaction for the selective Se-arylation of 2-selenohydantoins under base-free mild conditions via aryl boronic acids is described herein. This approach was used to synthesize novel 5-arylidene-3-substituted-2-(arylselanyl)-imidazoline-4-ones with high yields. The anticancer activity of the final compounds was evaluated in vitro against different cancer cells, and thus, the possibility of 5-arylidene-3-substituted-2-(arylselanyl)-imidazoline-4-ones successful application as cytotoxic agents was demonstrated.