On Statistical Relationship between ADRA2A Expression and the Risk of Breast Cancer Relapse

Bulletin of Experimental Biology and Medicine. 2014. Vol. 157. No. 4. P. 454–458.

Shkurnikov M. Y., V. V. Galatenko, Lebedev A. E., Podol’skii V. E., Tonevitskii E. A., Mal’tseva D. V.

The search for novel parameters to predict the risk of relapse in breast cancer was conducted. Significant correlation between the risk of relapse and α-2A adrenergic receptor (ADRA2A) expression was revealed using public microarray datasets. This relationship was confirmed by validation on independent microarray dataset. It was found that when assessing the risk of BC relapse, the accuracy of prediction based solely on the expression of ADRA2A gene is close to that made using OncotypeDX and MammaPrint test systems. In this case, addition of only one or two supplemental prognostic markers (for instance, expression of SQLE gene or SQLE andDSCC1genes) to ADRA2A ensures the accuracy of prediction not inferior to reliability of these test systems.

Ключевые слова: Gene expression, Рак молочной железы, Breast cancer, risk of relapse, α-2A adrenergic receptor, экспрессия гена, риск рецидива, α-адренорецептор 2A