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Взаимосвязь генотипа главного комплекса гистосовместимости класса I с летальностью COVID-19 у пациентов с сахарным диабетом
ДОКЛАДЫ РОССИЙСКОЙ АКАДЕМИИ НАУК. НАУКИ О ЖИЗНИ.. 2022. Т. 507. № 1. С. 515–519.
Shkurnikov M., Averinskaya D., Комаров А. Г., Карбышев И. А., Спешилов Г. И., Штинова И. А., Дорошенко Д. А., Вечорко В. И., Драпкина О. М.
Numerous studies have shown that diabetes mellitus (DM) increases the risk of death from COVID-19 by five
times. It is generally accepted that the high lethality of COVID-19 against the background of DM is due to
the main complications of this disease: micro- and macroangiopathies, heart and kidney failure. In addition,
it has been shown that acute respiratory viral infection increases interferon-gamma production and muscle
resistance to insulin, modulating the activity of effector CD8+ T-lymphocytes. The ability of CD8+ T lym-
phocytes to recognize SARS-CoV-2 infected cells depends on the individual set of major histocompatibility
complex class I (MHC-I) molecules. In this study, on a sample of 222 patients, the association of the MHC-
I genotype of patients with diabetes aged less than 60 years with the outcome of COVID-19 was studied. It
has been shown that lethal outcomes of COVID-19 in patients with DM are associated with the low affinity
of the interaction of an individual set of MHC-I molecules with SARS-CoV-2 peptides.
Ratnikov F., European Physical Journal: Special Topics 2026 P. 1–10
EEG recordings are often affected by the loss or corruption of individual channels due to electrode detachment, poor scalp contact, or external interference. Such channels must be accurately reconstructed before further analysis. In this study, we investigate Next-Generation Reservoir Computing (NG-RC) as a data-driven approach for reconstructing corrupted EEG channels and compare its performance with ...
Added: August 12, 2026
Lucas J., Hebbar P., Ryabov F. et al., / Series 10.64898/2026.07.21.739710 "10.64898/2026.07.21.739710". 2026.
A pangenome reference overcomes the inherent limitation of any individual reference genome by integrating the variation present in a population. We present the Human Pangenome Reference Consortium’s (HPRC) Release 2 (HPRC2), an openly available, second phase pangenome that is an approximately fivefold expansion in genome number over HPRC Release 1 (HPRC1) and measurable improvement in ...
Added: August 10, 2026
Sandlerskiy R., Elsevier USA, 2026.
Encyclopedia of Ecology, Third Edition, Four Volume Set - with over 300 chapters - once again provides a comprehensive reference work covering the current ideas and practices in ecology.
Ecology is the ideal field for studying complex, adaptive, and self-organizing systems and by observing and understanding ecosystems, it provides valuable insights into creating sustainable systems. This knowledge is ...
Added: August 9, 2026
Dadinova L., Petoukhov M., Mozhaev A. et al., Crystallography Reports 2026 Vol. 71 P. 52–58
Bacterial chromosomes are tightly packed in the cells due to interactions with specific nucleoid-associated proteins. Among them, the IHF protein draws attention due to its presumed influence on intracellular crystallization processes, leading to bacterial resistance to drugs. The crystal structure of the IHF heterodimer is known only in complex with a short DNA fragment, whereas ...
Added: August 6, 2026
Radygina A., Kulikova S., Herald of the Russian Academy of Sciences 2025 Vol. 95 No. 6 P. 963–970
Musical training has a significant impact on brain organization, leading to functional and structural
adaptations that enhance auditory, visual, motor, and cognitive processes. This study investigates how
extensive musical training shapes functional brain connectivity by comparing professional musicians and
non-musicians. Using EEG phase-locking value (PLV) analysis, we examined neural synchronization across
alpha, beta, and gamma frequency ranges during music ...
Added: August 5, 2026
Mikhaylets E. V., Razorenova A. М., Chernyshev V. L. et al., Scientific Reports 2026 Vol. 16 Article 23560
Meditation offers a naturalistic paradigm for studying introspection, yet the neural dynamics of advanced tantric practices remain largely unexplored. Buddhist Highest Yoga Tantra (BHYT) comprises a sequence of eight dissolution stages culminating in the “clear light” state. We recorded EEG during eyes-closed BHYT meditation performed in monasteries and hermitages (51 sessions from 36 male practitioners; ...
Added: July 29, 2026
Sun Z., Khvostikov A., Krylov A. et al., Machine Learning and Knowledge Extraction 2026 Vol. 8 No. 1 Article 8
Whole-slide histology images (WSIs) can exceed 100 k × 100 k pixels, making direct pixel-level segmentation infeasible and requiring patch-level classification as a practical alternative for downstream WSI segmentation. However, most approaches either treat patches independently, ignoring spatial and biological context, or rely on deep graph models prone to oversmoothing and loss of local tissue ...
Added: July 16, 2026
Turkina A., Vinogradova O., Lomaia E. et al., Annals of Hematology 2025 Vol. 104 P. 2707–2715
Vamotinib (PF-114) is a 3rd -generation, ATP-competitive oral tyrosine kinase inhibitor (TKI) active against wild-type and mutated BCR::ABL1 isoforms including BCR::ABL1T315I. We present final results of a phase-1 vamotinib dose-escalation study to identify maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) followed by expansion cohorts. 51 subjects with chronic myeloid leukaemia (CML) failing ≥ 1 2nd generation TKI or with BCR::ABL1T315I were ...
Added: July 16, 2026
Окнина Л. Б., Подлепич В. В., Sieber I. et al., Физиология человека 2026 Т. 52 № 3 С. 5–15
The aim of this study was to evaluate the frequency following response (FFR) for the analysis of the intact perception of syllables in humans. For this purpose, event-related potentials (ERPs) in response to isolated Russian syllables were recorded and analyzed in 29 healthy persons in two frequency ranges, standard (1-40 Hz) and high frequency (70-150 ...
Added: June 30, 2026
Ryskina H., Лобаева Т. А., Ануркина А. И., Ваш формат, 2025.
Я
Эволюция, экология, генетика человека, медицинская паразитология. Практикум. Аннотация
Аннотация к практикуму «Эволюция, экология, генетика человека, медицинская паразитология»
Учебное пособие «Эволюция, экология, генетика человека, медицинская паразитология. Практикум» (авторы: Лобаева Т. А., Рыскина Е. А., Ануркина А. И.; издательство «Ваш формат», 2025 год, 194 страницы) предназначено для студентов высших учебных заведений. Цель практикума — обеспечить комплексное освоение ключевых разделов биологии с акцентом на их прикладное значение в медицине. ...
Added: June 23, 2026
Herbert A., Cherednichenko O., Lybrand T. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 6 Article 2422
The double-stranded RNA editing enzyme ADAR1 connects two forms of genetic programming, one based on codons and the other on flipons. ADAR1 recodes codons in pre-mRNA by deaminating adenosine to form inosine, which is translated as guanosine. ADAR1 also plays essential roles in the immune defense against viruses and cancers by recognizing left-handed Z-DNA and ...
Added: June 22, 2026
Kyrchanova O., Kudryashova K., Ibragimov A. et al., Development 2025 Vol. 152 No. 19 Article dev205051
Drosophila homeotic gene Abdominal-B (Abd-B) is controlled throughout development by four infraabdominal (iab) regulatory domains, the active or repressed state of which is determined by initiators that have parasegment-specific enhancer activity at an early stage of embryonic development. For this reason, it has long been assumed that the enhancer activity and initiation function of these elements are synonymous. ...
Added: June 20, 2026
Kyrchanova O., Ksenia Kudryashova, Dubrovskaya V. et al., Open Biology 2025 Vol. 15 No. 11 Article 250192
The specification of abdominal segments A5 to A9 depends on the expression of Abdominal-B (Abd-B), which is regulated by four infraabdominal domains: iab-5 through iab-8,9. Each iab domain contains an initiation element that determines its active state, along with enhancers responsible for tissue-specific activation of Abd-B. These iab domains function autonomously due to their flanking boundaries, Fab-6, Fab-7 and Fab-8, which both block crosstalk between adjacent iab domains (insulator function) and facilitate long-range ...
Added: June 20, 2026
Kudryashova K.S., Deriglazova I. O., Osadchiy I. S. et al., Genes 2025 Vol. 16 No. 1 Article 3
Background/Objectives: Transcriptional promoters play an essential role in regulating protein expression. Promoters with weak activity generally lead to low levels of expression, resulting in fewer proteins being produced. At the same time, strong promoters are commonly used in studies using transgenic organisms as model systems. This approach can have various negative consequences for the organism, ...
Added: June 20, 2026
Ksenia Kudryashova, Filippova E., Kryukova E. et al., Archives of Biochemistry and Biophysics 2025 Vol. 769 Article 110437
β-Bungarotoxins (β-BuTx), consisting of covalently bound phospholipase A2 subunit (A-chain), a member of group Ia of secretory phospholipases A2, and non-enzymatic subunit (B-chain) structurally related to Kunitz-type protease inhibitors, block presynaptic neuromuscular transmission via a not completely defined mechanism of action. In vivo physiological studies revealed that the B-chain is targeting voltage-gated potassium channels of not identified subtypes. In our work, six β-BuTx isoforms were ...
Added: June 20, 2026
Cherednichenko O., Herbert A., Poptsova M., Computational and Structural Biotechnology Journal 2025 Vol. 27 P. 992–1000
Large language models (LLMs) in genomics have successfully predicted various functional genomic elements. While their performance is typically evaluated using genomic benchmark datasets, it remains unclear which LLM is best suited for specific downstream tasks, particularly for generating whole-genome annotations. Current LLMs in genomics fall into three main categories: transformer-based models, long convolution-based models, and state-space models ...
Added: June 19, 2026
Cherednichenko O., Poptsova M., Briefings in Bioinformatics 2025 Vol. 26 No. 2 Article bbaf129
Kolmogorov–Arnold networks (KANs) emerged as a promising alternative for multilayer perceptrons (MLPs) in dense fully connected networks. Multiple attempts have been made to integrate KANs into various deep learning architectures in the domains of computer vision and natural language processing. Integrating KANs into deep learning models for genomic tasks has not been explored. Here, we ...
Added: June 19, 2026
Aly Ismailov, Spallone A., Belogurov A. et al., Frontiers in Immunology 2025 Vol. 16 Article 1530305
Glioblastomas are the most prevalent primary brain tumors and are associated with a dramatically poor prognosis. Despite an intensive treatment approach, including maximal surgical tumor removal followed by radio- and chemotherapy, the median survival for glioblastoma patients has remained around 18 months for decades. Glioblastoma is distinguished by its highly complex mechanisms of immune evasion ...
Added: June 17, 2026
Lifshits A., Святохина Е. В., Одиссей: Человек в истории 2026 № 1 С. 156–173
This article introduces a new source for scholarly discussion on the history of Russian language, science, and culture in the late 17th century. Numerous Russian captions for engravings were discovered in a copy of the "Travnik" (Herbal) by the great Renaissance botanist and pharmacist Pietro Andrea Mattioli, published in Prague in German in 1563. In ...
Added: June 15, 2026
Madison A., Plandin F., Kuzmina T. et al., Palaeogeography, Palaeoclimatology, Palaeoecology 2026 Vol. 697 Article 113864
Unlike most other brachiopods, craniiforms lack a prominent pedicle, cement to a hard substrate by their ventral valve, and thereby can be easily distinguished in paleontological materials. In this study, we describe a new genus and species from the Porkuni Regional Stage of Northeastern Estonia (Baltica), corresponding to the lower part of the Hirnantian Stage ...
Added: June 15, 2026
Plandin F., Temereva E., Zoological Journal of the Linnean Society 2025 Vol. 205 No. 2 Article zlaf139
Although Brachiopoda represent a relatively small phylum, they exhibit significant morphological diversity. One of the central issues in understanding the evolution of the ancestral brachiopod body plan pertains to the homologies among body compartments across the different brachiopod subphyla: Craniiformea, Linguliformea, and Rhynchonelliformea. In this context, the pedicle stands out as one of the most ...
Added: June 15, 2026
Namsaraev Z., Nanzatov B., Kozlova A. et al., Scientific Reports 2026 Vol. 16 No. 1 Article 17769
Distilled fermented milk beverages are rare in food technology, despite the global prevalence of plant-based spirits. Currently, the production of distilled strong alcoholic beverages from fermented milk using traditional technologies is known only among Mongolic-speaking peoples and their Siberian neighbors. This study provides the first interdisciplinary analysis of darasun, a traditional Buryat spirit made from fermented ...
Added: June 10, 2026
Dvoynikova A., Маркитантов М. В., Рюмина Е. В. et al., Информатика и автоматизация (Труды СПИИРАН) 2021 Т. 20 № 5 С. 1116–1152
Начиная с 2019 года все страны мира столкнулись со стремительным распространением пандемии, вызванной коронавирусной инфекцией COVID-19, борьба с которой продолжается мировым сообществом и по настоящее время. Несмотря на очевидную эффективность средств индивидуальной защиты органов дыхания от заражения коронавирусной инфекцией, многие люди пренебрегают использованием защитных масок для лица в общественных местах. Поэтому для контроля и своевременного ...
Added: April 24, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Общественное здоровье 2024 Т. 4 № 4 С. 4–15
Introduction. The study is devoted to the analysis of the dynamics of the tobacco and alcohol use prevalence among the adult population during the COVID-19 pandemic.
The purpose of the study: to analyze the impact of the COVID-19 pandemic on the prevalence of tobacco and nicotine-containing products consumption among the adult population of the Russian Federation, men and ...
Added: April 9, 2026