Взаимосвязь генотипа главного комплекса гистосовместимости класса I с летальностью COVID-19 у пациентов с сахарным диабетом

ДОКЛАДЫ РОССИЙСКОЙ АКАДЕМИИ НАУК. НАУКИ О ЖИЗНИ.. 2022. Т. 507. № 1. С. 515–519.

Shkurnikov M., Averinskaya D., Комаров А. Г., Карбышев И. А., Спешилов Г. И., Штинова И. А., Дорошенко Д. А., Вечорко В. И., Драпкина О. М.

Numerous studies have shown that diabetes mellitus (DM) increases the risk of death from COVID-19 by five

times. It is generally accepted that the high lethality of COVID-19 against the background of DM is due to

the main complications of this disease: micro- and macroangiopathies, heart and kidney failure. In addition,

it has been shown that acute respiratory viral infection increases interferon-gamma production and muscle

resistance to insulin, modulating the activity of effector CD8+ T-lymphocytes. The ability of CD8+ T lym-

phocytes to recognize SARS-CoV-2 infected cells depends on the individual set of major histocompatibility

complex class I (MHC-I) molecules. In this study, on a sample of 222 patients, the association of the MHC-

I genotype of patients with diabetes aged less than 60 years with the outcome of COVID-19 was studied. It

has been shown that lethal outcomes of COVID-19 in patients with DM are associated with the low affinity

of the interaction of an individual set of MHC-I molecules with SARS-CoV-2 peptides.

Keywords: сахарный диабет, главный комплекс гистосовместимости, COVID-19, HLA