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Propagating Dynamics of Interictal Spikes Reconstructed From MEG Recordings
P. 190–190.
Publication based on the results of:
Vorobyova A., Feurra M., Pavone E. F. et al., Frontiers in Human Neuroscience 2025 Article 1509163
Introduction: The hippocampus plays a crucial role in episodic memory. Given its complexity, the hippocampus participates in multiple aspects of higher cognitive functions, among which are semantics-based encoding and retrieval. However, the “where,” “when” and “how” of distinct aspects of memory processing in the
hippocampus are still under debate.
Methods: Here, we employed a visual associative memory task that involved ...
Added: February 20, 2025
Iurina E., Bailles E., Carreño M. et al., Epilepsy Research 2021 Vol. 177 Article 106784
Objective: To determine changes in dimensions of personality in a sample of patients suffering from drug-resistant epilepsy at the 1-year follow-up following surgery, compared to non-surgically treated controls.
Methods: We conducted a prospective comparative controlled study, including drug-resistant epilepsy surgery candidates. Demographic, psychiatric, neurological, and psychological data were recorded. Presurgical and 12-months follow-up evaluations were performed. Personality dimensions ...
Added: January 29, 2025
Белокопытов А. С., Kleeva D., Ossadtchi A., , in: Advances in Neural Computation, Machine Learning, and Cognitive Research VIII.: Springer, 2024. P. 317–326.
Added: October 23, 2024
Gerstl J. ., Alina Kiseleva, Imbach L. et al., Scientific Reports 2023 No. 13 Article 21313
We evaluate whether interictal spikes, epileptiform HFOs and their co-occurrence (Spike + HFO) were
included in the resection area with respect to seizure outcome. We also characterise the relationship
between high frequency oscillations (HFOs) and propagating spikes. We analysed intracranial EEG of
20 patients that underwent resective epilepsy surgery. The co-occurrence of ripples and fast ripples
was considered an ...
Added: March 13, 2024
Karpychev V., Malyutina S., Zhuravleva A. et al., Epilepsy and Behavior 2023 Vol. 147 Article 109407
Objective
Temporal lobe epilepsy (TLE) is a network disorder that alters the total organization of the language-related network. Task-based functional magnetic resonance imaging (fMRI) aimed at functional connectivity is a direct method to investigate how the network is reorganized. However, such studies are scarce and represented mostly by the resting-state analysis of the individual connections between ...
Added: October 21, 2023
Sitovskaya D., Zabrodskaya Y., Parshakov P. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 19 Article 14490
The European Commission of the International League Against Epilepsy (ILAE) has identified glial mechanisms of seizures and epileptogenesis as top research priorities. The aim of our study was to conduct a comparative analysis of the expression levels of cytoskeletal proteins (glial fibrillar acidic protein (GFAP) and vimentin), protective protein S100, and proapoptotic caspase-3 protein in ...
Added: October 2, 2023
Vitobello A., Mazel B., Lelianova V. et al., American Journal of Human Genetics 2022 Vol. 109 No. 8 P. 1436–1457
ADGRL1 (latrophilin 1), a well-characterized adhesion G protein-coupled receptor, has been implicated in synaptic development, maturation, and activity. However, the role of ADGRL1 in human disease has been elusive. Here, we describe ten individuals with variable neurodevelopmental features including developmental delay, intellectual disability, attention deficit hyperactivity and autism spectrum disorders, and epilepsy, all heterozygous for ...
Added: November 23, 2022
Chirkov V., Kryuchkova A., Koptelova A. et al., Plos One 2022 Vol. 17 No. 10 Article e0275063
The reliable identification of the irritative zone (IZ) is a prerequisite for the correct clinical evaluation of medically refractory patients affected by epilepsy. Given the complexity of MEG data, visual analysis of epileptiform neurophysiological activity is highly time consuming and might leave clinically relevant information undetected. We recorded and analyzed the interictal activity from seven ...
Added: November 14, 2022
O. Dogonasheva, Kasatkin D., Boris Gutkin et al., Chaos 2022 Vol. 32 No. 10 Article 101101
Over the past decades, one of the most exciting and fast developed area of modern synchronization theory is the study of chimera states. Such chimera states states are characterized by the coexistence of multiple synchronous and asynchronous domains, despite that the network topology does not at all predict such structures. Moreover, these states are of interest ...
Added: September 16, 2022
Kleeva D., Soghoyan G., Komoltsev I. et al., Journal of Neural Engineering 2022 Vol. 19 No. 3 Article 036003
Objective. Epilepsy is a widely spread neurological disease, whose treatment often requires resection of the pathological cortical tissue. Interictal spike analysis observed in the non-invasively collected EEG or MEG data offers an attractive way to localize epileptogenic cortical structures for surgery planning purposes. Interictal spike detection in lengthy multichannel data is a daunting task that ...
Added: May 29, 2022
Dogonasheva O., Касаткин Д. В., Гуткин Б. С. et al., Chaos, Solitons and Fractals 2021 Vol. 153 Article 111541
We propose a robust universal approach to identify multiple network dynamical states, including stationary and travelling chimera states based on an adaptive coherence measure. Our approach allows automatic disambiguation of synchronized clusters, travelling waves, chimera states, and asynchronous regimes. In addition, our method can determine the number of clusters in the case of cluster synchronization. ...
Added: November 1, 2021
Karpychev V., , in: 33rd international Epilepsy Congress Bangkok, Thailand | 22–26 June 2019 Satellite Symposia AbstractsVol. 60. Issue S2.: Wiley Online Library, 2019. P. 86–87.
Purpose: High frequency oscillations (HFO 80–500 Hz) are recognized as biomarkers for epileptogenic brain tissue to be resected in epilepsy surgery. While several studies describe group level statistics, assessment in the individual patient still needs further validation. Here we compare automated HFO analysis with routine pre- surgical evaluation.
Method: We analyzed long- term stereo EEG recordings ...
Added: November 17, 2020
Fedele T., Ramantani G., Sarnthein J., Clinical Neurophysiology 2019 Vol. 130 No. 5 P. 624–626
Over 20 years of enthusiastic research have served to establish high frequency oscillations (HFO) as a promising biomarker of epileptogenicity, both in animal models and in refractory focal epilepsy patients (Jacobs et al., 2010, 2012; Fedele et al., 2017b; Frauscher et al., 2017; Zijlmans et al., 2017; Gotman, 2018). Several studies have relied on higher ...
Added: July 23, 2019
Adaptation and inhibition control pathological synchronization in a model of focal epileptic seizure
Buchin A., Kerr C. C., Huberfeld G. et al., eNeuro 2018 Vol. 0019-18 P. 1–14
Pharmacoresistant epilepsy is a common neurological disorder in which increased neuronal intrinsic excitability and synaptic excitation lead to pathologically synchronous behavior in the brain. In the majority of experimental and theoretical epilepsy models, epilepsy is associated with reduced inhibition in the pathological neural circuits, yet effects of intrinsic excitability are usually not explicitly analyzed. Here ...
Added: December 20, 2018
Arkhipova N., Aleksandrov M., Clinical Neurophysiology 2018 Vol. 129 No. 5 P. 110–111
Electrocorticography (ECoG) is a standard procedure for the localization of the epileptogeniczone during the surgical treatment of symptomatic epilepsy. The purpose of this study was to evaluate the diagnostic efficacy of intraoperative pre- and post-resective ECoG for the localization of the epileptogenic zone in patients with symptomatic epilepsy associated with supratentorial brain tumors. 1. In the surgical treatment of symptomatic epilepsy associated with intracerebral neoplasm, intraoperative ...
Added: June 26, 2018
Arkhipova N., Aleksandrov M., Chukhlovin A. et al., Clinical Neurophysiology 2017 Vol. 128 No. 9 P. 228
Objective Removal of brain tissue generating pathological high-frequency oscillations (pHFOs) has been related to better seizure outcome than resection of seizure onset zone. However, there is still a lack of understanding what oscillations are to be considered pathological. Methods A female patient (age 53) with 10 year duration of temporal lobe tumor-related epilepsy was admitted ...
Added: June 26, 2018