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Methionine dependence of cancer and aging: methods and protocols
Манухов И. В.
Cancer cells require exogenous methionine for survival and therefore methionine restriction is a promising
avenue for treatment. The basis for methionine dependence in cancer cells is still not entirely clear. While
the lack of the methionine salvage enzyme methylthioadenosine phosphorylase (MTAP) is associated with
methionine auxotrophy in cancer cells, there are other causes for tumors to require exogenous methionine.
Restricting methionine by diet or by enzyme depletion, alone or in combination with certain chemotherapeutics,
is a promising antitumor strategy.
Chapters
Манухов И. В., , in: Methionine dependence of cancer and aging: methods and protocols.: Springer Nature. Springer Science+Business Media, LLC, Humana Press., 2019. Ch. 18 P. 243–261.
The anti-cancer efficacy of methionine γ-lyase (MGL) from Clostridium sporogenes (C.
sporogenes) is described. MGL was active against cancer cells in vitro and in vivo. Doxorubicin
(DOX) and MGL were more effective on A549 human lung cancer growth inhibition than either
agent alone in vitro and in vivo. The growth inhibitory effect of DOX + MGL on A549 ...
Added: March 3, 2020
Priority areas:
engineering science
Language:
English
Blank I., Klucharev V., Shestakova A., Frontiers in Human Neuroscience 2026
In video games, the participants are active agents who pursue various goals within gaming environments that increasingly resemble real life. As a result, video games are increasingly offering tools for neuroimaging studies aiming to elucidate the neural basis of human perceptual, cognitive, and emotional functions. Here, we review these studies. The first studies used computerized ...
Added: June 6, 2026
Boldyreva M., Mohammad R., Agareva M. et al., FRONTIERS IN ANIMAL SCIENCE 2026 Vol. 7 Article 1837838
Mammals from arid ecosystems face distinct physiological challenges: water scarcity and unpredictable food availability require the integration of energy storage, maintenance of water balance, and flexible switching between nutrients. Our previous study demonstrated lower fasting blood glucose levels in the desert rodent Acomys cahirinus (African spiny mouse), which also possesses a unique regenerative ability. The aim of ...
Added: June 3, 2026
Лебедева Д. А., Вестник Воронежского государственного университета. Серия: Право 2026 № 1 С. 66–77
The article is devoted to the study of problems in the fi eld of ensuring the protection and
portability of patient data in medical information and analytical systems (hereinafter – MIAS). The
purpose of the study is a comprehensive analysis of the legal regulation of the MIAS of the constituent
entities of the Russian Federation. The study identifi ...
Added: June 3, 2026
Biryukova A., Zasimova L. S., Вопросы статистики 2026 Т. 33 № 2 С. 40–57
The paper examines changes in the economic affordability of cigarettes in Russian regions in 2011–2023. Using fixed-effects models, it estimates the impact of prices, incomes, and tobacco affordability (the ratio of per capita income to cigarette price), on three indicators: retail sales of cigarettes per capita, adult population spending on tobacco products, and the share of these ...
Added: June 1, 2026
Kazantseva A. V., A.V. Toropova, Khusnutdinova E. K. et al., ВАВИЛОВСКИЙ ЖУРНАЛ ГЕНЕТИКИ И СЕЛЕКЦИИ, Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук» (ИЦиГ СО РАН) (Новосибирск) 2025 Vol. 30 No. 3 P. 470–481
The development of musical abilities, including absolute pitch, musical memory, rhythm sense, and musicality, at a high degree is determined by a hereditary component (up to 68 %). The studies implementing a genome-wide linkage and association approach to musical aptitude have revealed more than 100 genetic loci. This spectrum is comprised of the genes encoding ...
Added: May 29, 2026
Mokienko O., Zisman M. A., Bobrov P. et al., American Journal of Physical Medicine and Rehabilitation 2026 Vol. 105 No. 6 P. 555–563
Brain-computer interfaces (BCIs) represent a promising technology for restoring lower limb motor functions and gait after stroke. The application of BCIs in this field is supported by a limited number of studies. The objective of the review was to systematically and critically evaluate the current evidence on the use of BCIs for lower limb function ...
Added: May 28, 2026
Anna Davidovich, Anna N. Shestakova, Arzumanyan N. et al., Frontiers in Psychology 2026 Vol. 17 Article 1764306
Background:
Delay discounting refers to the tendency to choose sooner, smaller rewards over larger, later rewards. Many previous studies link this tendency positively to reward sensitivity, yet the specific mechanisms behind this association remain poorly understood. Reward sensitivity may relate to delay discounting through at least three possible pathways: increased sensitivity to reward size, increased sensitivity ...
Added: May 27, 2026
Helen Selorm Wohoyie, Anikin V. A., Tomsk State University Journal of Philosophy, Sociology and Political Science 2026 Vol. 90 P. 204–211
Menstrual health serves as a critical litmus test for state intervention in contexts where women’s bodily experiences are historically shaped by stigma, cultural taboos, and structural violence. Drawing on Joseph Gusfield’s theory of social problems, this review traces the moral passage of menstruation in Ghana (1992–2025) from a privately managed, stigmatized phenomenon to a matter ...
Added: May 26, 2026
Kochetkova E., Kostanian D., Martynova O. et al., Brain Topography 2026 Vol. 39 No. 4 Article 51
Letter recognition is assumed to involve several levels of analysis, including coarse tuning for category and novelty and more fine tuning for specific features, related to letter orientation. We employed an oddball fast periodic visual stimulation (FPVS) paradigm with magnetoencephalography (Elekta VectorView, 306 sensors) to study neural discrimination responses in the source space. Using contrasts ...
Added: May 24, 2026
Zaikin A., Sviridov I., Sosedka A. et al., Technologies 2026 Vol. 14 No. 2 Article 84
High-dimensional tabular data are common in biomedical and clinical research, yet conventional machine learning methods often struggle in such settings due to data scarcity, feature redundancy, and limited generalization. In this study, we systematically evaluate Synolitic Graph Neural Networks (SGNNs), a framework that transforms high-dimensional samples into sample-specific graphs by training ensembles of low-dimensional pairwise ...
Added: May 23, 2026
Borovikova I., Uporov I., Okhrimenko G. et al., Journal of Structural Biology 2026 Vol. 218 No. 2 Article 108315
Single amino acid substitutions in the ATP-binding domain of ACVRL1, a key receptor in the bone morphogenetic protein (BMP) signaling pathway, are frequently classified as variants of uncertain significance (VUS), complicating molecular diagnosis for pulmonary arterial hypertension (PAH) and Hereditary Hemorrhagic Telangiectasia (HHT). Since aberrant ATP binding disrupts downstream SMAD1/5/8 phosphorylation, we employed molecular dynamics ...
Added: May 20, 2026
Goltseva Y., Tsokolaeva Z., Beloglazova I. et al., Stem Cell Research and Therapy 2026 Vol. 17 No. 1 Article 112
Background Cardiac fibrosis represents a significant health burden, with endothelial dysfunction and damaged
perivascular microenvironment increasingly recognized as key contributors to fibrotic remodeling. The urokinase
plasminogen activator receptor (uPAR), a critical component of the urokinase system, plays a pivotal role in vascular
remodeling and fibrosis. While prior evidence indicates that uPAR deficiency leads to microvascular dysfunction and
perivascular fibrosis, ...
Added: May 19, 2026
Гущина В. А., / Series chemrxiv-2023-vpzhz-v2 "ChemRxiv". 2023.
All-inorganic perovskite CsPbBr3 and Cs4PbBr6 nanoparticles are being intensively studied due to their unique properties and wide range of applications; however, however, the nature of their optical properties is not yet fully understood due to the difficulty of synthesis of singlephase nanoparticles. In this article we describe the features of the synthesis of single-phase particles ...
Added: May 14, 2026
Карцева М. А., Peresetsky A., / Высшая школа экономики. Серия WP2 "Количественный анализ в экономике". 2026. № WP2/2026/01.
This study examines the association between health status among elderly individuals living alone and pet ownership (cats, dogs). We employ data from the “Time Use Survey” conducted by the Federal State Statistics Service (Rosstat) in 2019, which contains information on more than 10,000 elderly individuals living alone aged 60 or older in Russia, including data ...
Added: May 8, 2026
Perevoznyuk G., Batov A., Pleskovskaya A. et al., Scientific Reports 2026 Vol. 16 Article 13098
Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...
Added: May 5, 2026
Sosnin E. I., Vasil’ev Y. L., R.A. Solovyev et al., Computer Optics 2025 Vol. 49 No. 6 P. 1129–1137
In this article, we present a new unique dataset for dental research – AlphaDent. This dataset is based on the DSLR camera photographs of the teeth of 295 patients and contains over 1200 images. The dataset is labeled for solving the instance segmentation problem and is divided into 9 classes. The article provides a detailed ...
Added: May 4, 2026
Назаренко А. Г., Федоров М. В., Moshkin A. et al., Вестник Росздравнадзора 2026 № 1 С. 14–29
Multimodal foundation models and medical multimodal large language models are establishing a new class of diagnostic clinical decision support systems capable of operating on heterogeneous data sources, including medical imaging (X-ray, CT, MRI, ultrasound, histopathology), physiological signals (ECG, EEG), clinical text (electronic health records, reports, discharge summaries), laboratory measurements, molecular profiling data, and related modalities. ...
Added: May 4, 2026
Radygina A., Zaripova J., Semenova D. et al., FRONTIERS IN NUTRITION 2026 Vol. 13 Article 1741707
This paper introduces a novel, open-access dataset designed to advance research into early childhood eating behaviors and their familial determinants. The dataset integrates anthropometric measurements (weight, height, age, BMI, and Estimated Energy Requirement) from 203 children aged 4–14 years alongside rich, granular data on food selection behaviors gathered via Dish-I-Wish—a custom, gamified web application developed ...
Added: April 24, 2026
Kashevnik A., Glekler E., Artemenko E. et al., Scientific data 2026 Article 7209
We present a multimodal dataset containing electroencephalography (EEG), electrocardiography (ECG), and video recordings from 49 participants. Each participant completed a single session lasting approximately 45 minutes. During each session they performed five tasks: resting state, inward concentration (focusing on the center of the forehead), outward concentration (visual search), and mind-wandering. EEG data were recorded from ...
Added: April 23, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
Pilé I., Deng Y., Shchur L., / Series arXiv "math". 2026. No. 2604.10254.
We investigate the spatial overlap of successive spin configurations in Markov chain Monte Carlo simulations using the local Metropolis algorithm and the Svendsen-Wang and Wolff cluster algorithms. We examine the dynamics of these algorithms for two models in different universality classes: the Ising model and the Potts model with three components. The overlap of two ...
Added: April 20, 2026
Гулов Д. М., Елумеева Т. Г., Федоров Н. И. et al., Журнал общей биологии 2024 Т. 85 № 2 С. 83–94
Plant functional traits are important for the formation of plant communities and for the ability of plants to dominate there. The comparison of mean trait values of organisms within community with that for the random samples of the local biota allows estimating the importance of the trait for the formation of the community composition. The ...
Added: April 19, 2026
Enchilik P. R., G.V.Klink, Semenkov I. N., Science of the Total Environment 2025 Vol. 998 Article 180219
Natural regeneration of forest soils affected by agricultural practices is a common phenomenon in many regions worldwide, particularly in boreal ecosystems. Affecting soil quality, the partitioning of extractable fractions of heavy metals and metalloids (HMMs) is not studied during natural regeneration. The following stages of natural regeneration after plowing have been identified in the Smolenskoye ...
Added: April 19, 2026
Chernyshov D., Satanin A., Shchur L., / Series arXiv "math". 2025.
We investigate the boundary separating regular and chaotic dynamics in the generalized Chirikov map, an extension of the standard map with phase-shifted secondary kicks. Lyapunov maps were computed across the parameter space (K,K(α, τ)) and used to train a convolutional neural network (ResNet18) for binary classification of dynamical regimes. The model reproduces the known critical ...
Added: November 21, 2025