Researchers from HSE MIEM and Samara University have developed the LRF-3D algorithm to automatically bypass idle nodes in three-dimensional networks-on-chip. Thanks to its hierarchical architecture, the algorithm outperforms existing solutions in both speed and path accuracy, improving processor reliability for use in data centres, supercomputers, and AI computing. The source code and test results are publicly available.
Researchers at HSE University have developed a model for generating promoters and enhancers—DNA sequences that regulate gene activity. The model works directly with DNA nucleotides, without first transforming them into a continuous numerical representation. This solution could be useful for applications in synthetic biology and gene therapy. The study results were presented at the ICLR 2026 Workshop ‘Generative AI in Genomics (Gen^2): Barriers and Frontiers.’
The International Laboratory for Social Integration Research (ILSIR) at HSE University studies the challenges faced by vulnerable groups and explores ways to help them participate fully in everyday life. To develop effective solutions, the laboratory’s researchers combine cutting-edge methods with practical fieldwork. In this interview with the HSE News Service, Laboratory Head Elena Iarskaia-Smirnova discusses the laboratory’s work.
Sivkina A., Karlova M., McCullough L. et al., Communications Biology 2022 Vol. 5 No. 1 Article 2
FACT is a histone chaperone that participates in nucleosome removal and reassembly during transcription and replication. We used electron microscopy to study FACT, FACT:Nhp6 and FACT:Nhp6:nucleosome complexes, and found that all complexes adopt broad ranges of configurations, indicating high flexibility. We found unexpectedly that the DNA binding protein Nhp6 also binds to the C-terminal tails ...
Maltseva D., Tonevitsky A., Gabibov A., Molecules 2017 Vol. 22 No. 5 P. E808
Astrocytes are considered to be an important contributor to central nervous system (CNS) disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected by cytokines released by lymphocytes, penetrating the blood–brain barrier—in particular, the classical pro-inflammatory cytokine interferon-gamma (IFNγ). We report here the transcriptomal profiling of astrocytes treated using IFNγ and benztropine, a putative ...
Shchebetenko S., Semyonova P. I., Психология. Журнал Высшей школы экономики 2011 Т. 8 № 3 С. 130–138
В статье показана возможность предсказания посредством суточного локуса спада-подъема в деятельности медицинских работников в течение рабочей смены. Кратко рассматриваются предпосылки исследования. В исследовании приняли участие 189 медицинских работников Перми. Была разработана самоотчетная Шкала суточного локуса, продемонстрировавшая приемлемую внутреннюю согласованность, дивергентную и предиктивную валидность. Показано, что суточный локус опосредует эффект интернальности в производственных отношениях на суточный ...
Kudriaeva A., Galatenko VV, Maltseva D. et al., Molecules 2017 Vol. 22 No. 5 P. 808-1–808-9
Astrocytes are considered to be an important contributor to central nervous system (CNS) disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected by cytokines released by lymphocytes, penetrating the blood-brain barrier-in particular, the classical pro-inflammatory cytokine interferon-gamma (IFNγ). We report here the transcriptomal profiling of astrocytes treated using IFNγ and benztropine, a ...