?
Применение лекарственных препаратов на основе нуклеиновых кислот в терапии различных заболеваний
Nucleic acids (NA) are the molecular basis of all living organisms. Th s class of chemical compounds was discovered in 1968 by Friedrich Miescher. Since then, their properties have been studied by scientists from all over the world. Initially, nucleic acids were obtained in the form of nucleoproteins from purulent secretions. Further, such a source of NA was replaced by Misher with salmon milt. Th s alternative turned out to be quite expedient and is still relevant today. DNA is isolated from salmon milk for the production of a drug such as Derinat. However, NA-based drugs are currently obtained not only by extraction from animal organs, but also by chemical synthesis or from microorganisms. For the fi st time, humanity thought about the use of nucleic acids as therapeutic agents back in the 19th century. At that time, they did not even exist as independent chemicals in the scientific paradigm. Already in 1892, an article was published on the medicinal properties of nucleic acids. Such drugs have both radioprotective and immunomodulatory properties, increasing overall resistance to certain infections, etc. Every year more and more benefic al effects of drugs based on NA are found in various pathologies. DNA has immunostimulatory properties due to CpG motifs in its sequence, which have an immunostimulatory effect. Currently, NA-based drugs do not have a wide clinical application, but their effectiveness has been confi med by many scientific studies, and therefore we can assume that the increase in popularity of such drugs among medical professionals is only a matter of time.