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Belgrade BioInformatics Conference 2016 Proceedings Belgrade, June 20th-24th

2017.
Vladik Avetisov, Ekaterina Borshcheva.

In this paper we present the studies of an ultrametric mathematical model for protein operation and give them physical interpretations that extend the conventional view of ensymatic activity regulation. The model is based on a representation of a multidimentional rugged energy landscapes by a hierarchy of nested basins of local minima and an approximation of protein dynamics with an ultrametric random walk. In contrast to an ordinary random walk, the ultrametric random walk is more suitable for describing of multiscale conformational dynamics and it is consistent with the kinetic features of ligand binding. Using our ultrametric model we show different ways to regulate enzymatic activity.

Belgrade BioInformatics Conference 2016 Proceedings Belgrade, June 20th-24th