Currently, innovations are the main competitive advantage of small-sized enterprises in many developed countries. Innovative activities of microenterprises in Russia, making over 93% of small business, stay beyond reporting and specialised research. Given that, the objective of the research was a revealing interrelation of the results of microenterprises’ activities and the innovative activities of enterprises in regions. Collections of statistical reports by the Russian Federal State Statistics Service as well as independent research materials, were used as information sources. Federal subjects were used as objects, correlation and regression analysis was the research methodology. The primary attention in the paper is paid to the possibility of indirect assessment of microenterprises’ innovative activities in regions, looking for factors and forms of their interaction assisting the development of the potential of this small group of economic agents. As a result, it was found out that intensity of microenterprises’ distribution, strengthened by intermediary’s (mediator’s) influence, is mostly interrelated with innovative activities, with the region’s e-development index serving as mediator.