50% patients with chronic disease shows unintentional and intentional medication non-adherence. Medication non-adherence causes 4 to 10% of preventable healthcare losses. SMS reminders are associated with significant improvement in adherence rates. The current paper tests whether the question-behavior effect (QBE) could improve SMS reminders effectiveness. Preliminary RCT (N=40) shows positive, but not significant effect of QBE/SMS combination on medication adherence rates (ASD=0.249 (95% C. I. -0.061 – 0.560)), which corresponds to the predicted effect size (ASD=0.166 (95% C. I. 0.044 – 0.276)). Additional research is required for confirmation of QBE/SMS combination effectiveness.