The aim of this paper is to identify the determinants of migration within Russia by distinguishing between eastern (Asian) and western (European) regions. Using Russian official data for the observation period 2001–2010, we estimate non-spatial panel and spatial panel lag of X model regressions for migration rates of 78 Russian regions with fixed effects. We apply in-migration, out-migration, and net-migration measures as dependent variables and distinguish between internal and external migration. The results indicate that migrants react to changes in labor demand in eastern regions, while wealth makes western regions attractive. Furthermore, universities hinder out-migration of eastern regions, but the share of tertiary educated persons has no measurable effect.