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Алгоритмы локальной минимизации силового поля для трехмерного представления макромолекул
Журнал вычислительной математики и математической физики. 2019. Т. 59. № 12. С. 2060-2076.
Аникин А. С., Большакова О. А., Гасников А. В., Горнов А. Ю., Ермак Т. В., Макаренко Д. В., Морозов В. П., Нетеребский Б. О., Yakovlev P.
Karpychev V., Balatskaya A., Utyashev N. et al., Frontiers in Human Neuroscience 2022 No. 16 Article 984306
High-frequency oscillations (HFO) are a promising biomarker for the identification of epileptogenic tissue. While HFO rates have been shown to predict seizure outcome, it is not yet clear whether their morphological features might improve this prediction. We validated HFO rates against seizure outcome and delineated the distribution of HFO morphological features. We collected stereo-EEG recordings ...
Added: October 1, 2022
Baulin E., Roytberg M. A., Астахова Т. В., Математическая биология и биоинформатика 2012 Т. 7 № 2 С. 567-571
Предложена классификация элементов вторичной структуры РНК, которая является обобщением классификации петель, предложенной Мэтьюзом и Тернером. Эта классификация позволяет единообразно описывать структуры как содержащие, так и не содержащие псевдоузлы. ...
Added: January 30, 2013
Krivovicheva V., Bubyrev A., Kalinin S. et al., ChemMedChem 2023 Vol. 18 No. 10 Article e202200607
A newly introduced diazo reagent, 1-diazo-N,N-bis(4-methoxybenzyl)methanesulfonamide, enables access to a range of azole-based primary sulfonamides via [3+2] cycloaddition followed by protecting group removal. Such compounds are representative of the sulfonamide chemical space highly relevant but hitherto not investigated in the context of inhibition of therapeutically relevant isoforms of carbonic anhydrase enzyme. Using this reagent, three ...
Added: January 26, 2024
Zhang T., Yin C., Fedorov A. et al., Nature 2022 Vol. 606 No. 7914 P. 594-602
Only a small proportion of patients with cancer show lasting responses to immune checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an emerging determinant of resistance to ICB therapy and prevents ICB responsiveness by repressing immunogenic double-stranded RNAs (dsRNAs), such as those arising from the dysregulated expression of endogenous retroviral elements (EREs)1,2,3,4. These dsRNAs ...
Added: May 28, 2022
М. : Издательский дом "Типография" Россельхозакадемии, 2014
Vserossiyskaya nauchnaya konferentsiya 31 yanvarya 2014 g. "Matematika, informatika, estestvoznanie v ekonomike i v obshchestve". ...
Added: February 7, 2014
Vnukov A., Егоров И. В., Горный информационно-аналитический бюллетень (научно-технический журнал) 2014 № 1 С. 238-241
This article deals with digital image scaling and optimizing of calculations by means of parallel processing. It is argued that the most efficient structure for this task is that of many-staged processing. Ii proposed to use FPGA as the hardware basis. The main velocity advantage of pipelined approach as compared with one-pass processing is the ...
Added: May 27, 2014
Proceedings of the IEEE 2021 P. 450-454
Anxiety is one of the most prevalent mental disorders, affecting approximately 5-10% of the adult population worldwide. It can severely impact quality of life, but also place a large burden on the health systems. Despite its omnipresence and impact on mental and physical health, most of the individuals suffering from anxiety do not receive appropriate ...
Added: October 6, 2021
Tomsk : ., 2010
Added: November 18, 2013
Derkach K., Maxim A. Gureev, Babushkina A. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 5 Article 4498
Dual inhibitors of protein phosphotyrosine phosphatase 1B (PTP1B)/T-cell protein phosphotyrosine phosphatase (TC-PTP) based on the 3-(hydroxymethyl)-4-oxo-1,4-dihydrocinnoline scaffold have been identified. Their dual affinity to both enzymes has been thoroughly corroborated by in silico modeling experiments. The compounds have been profiled in vivo for their effects on body weight and food intake in obese rats. Likewise, ...
Added: February 1, 2024
Babich O., Larina V., Krol O. et al., Pharmaceutics 2023 Vol. 15 No. 2 Article 616
Tanacetum vulgare is an herbaceous plant widely used in folk medicine. It is rich in phenolic acids and flavonoids, which have pharmacological and medicinal properties, such as anthelmintic, antispasmodic, tonic, antidiabetic, diuretic, and antihypertensive. This study aimed to confirm the presence of biologically active substances in Tanacetum vulgare and to determine the pharmacological spectrum of ...
Added: February 1, 2024
И. А. Хромов, Л. С. Восков, Информационные технологии (Российская Федерация) 2022 Т. 28 № 11 С. 570-579
Wireless body area network (WBAN) provides energy-efficient data transfer between wearable devices. Traditional WBAN consists of large and high-power consumption devices. Intrabody communication (IBC) is one of the technologies used by WBAN. IBC transmits data within the human body, consisting of different tissues. When developing devices for WBAN, modeling is necessary due to the signal ...
Added: February 1, 2023
Savchenko A., Optical Memory and Neural Networks (Information Optics) 2013 Vol. 22 No. 3 P. 184-192
The research subject is the computational complexity of the probabilistic neural network (PNN) in the pattern recognition problem for large model databases. We examined the following methods of increasing the efficiency of a neuralnetwork classifier: a parallel multithread realization, reducing the PNN to a criterion with testing of homogeneity of feature histograms of input and ...
Added: September 10, 2013
Novikov R., Armeev G., Gribkova A. et al., Microscopy and Microanalysis 2020 Vol. 26 No. S2 P. 310-311
At the center of the modern CRISPR/Cas genome editing revolution is the engineered ribonucleoprotein complex of the Cas9 protein with sgRNA that is able to bind and cleave DNA at specific loci. The targeted activity is conferred by the ability of the complex to bind to the DNA regions which are complementary to the parts ...
Added: September 14, 2021
Боброва Е. В., Решетникова В. В., Volkova K. et al., Журнал высшей нервной деятельности им. И.П. Павлова 2017 Т. 67 № 4 С. 485-492
Исследовали обучение управлению системой “Интерфейс мозг-компьютер” (ИМК) с помощью специально разработанного тренинга. Тренинг включал осуществление медленных циклических движений правой и левой рукой (длительность каждого движения соответствовала длительности представлений движений руки при работе с ИМК), представление этих движений, а также спокойное сидение до начала движений. До проведения тренинга и после него осуществлялось управление ИМК. По тесту ...
Added: October 20, 2017
Красноярск : ИВМ СО РАН, 2013
Труды Пятой Международной конференции «Системный анализ и информационные технологии» САИТ-2013 (19–25 сентября 2013 г., г.Красноярск, Россия): ...
Added: November 18, 2013
Goncharov R., Сапанов П. М., Яшунский А. Д., Социология власти 2013 № 3 С. 57-72
В статье представлена технология, позволяющая собирать в полевых исследованиях пространственно локализованные данные об объектах городской среды. Технология основана на автоматической привязке фотографий к пространственным координатам. Приведен план полевых и камеральных мероприятий, предложены варианты ГИС-обработки собираемых таким образом данных. В качестве примера приведены данные об использовании белорусского языка в общественном пространстве городов Белоруссии. ...
Added: April 12, 2015
Lukashina N., Kartysheva E., Spjuth O. et al., Journal of Cheminformatics 2022 Vol. 14 Article 49
Polypharmacy refers to the administration of multiple drugs on a daily basis. It has demonstrated effectiveness in treating many complex diseases , but it has a higher risk of adverse drug reactions. Hence, the prediction of polypharmacy side effects is an essential step in drug testing, especially for new drugs. This paper shows that the ...
Added: October 11, 2022
Kertesz-Farkas A., Noble W., Journal or Proteome Research 2015 Vol. 14 No. 8 P. 3027-3038
Added: September 25, 2015
Bakanov V. M., М. : Издательство Московского государственного университета приборостроения и информатики, 2014
The manual sets out the requirements of science and industry, leading to use of multicomputer systems and multiprocessor systems, which inevitably use the principle of parallel computing, background and state of the art, describes the main approaches to the organization of multiprocessor computer systems, development of parallel algorithms for the numerical solution of problems and ...
Added: February 3, 2015
Rogacheva E., Kraeva L., Lukin A. et al., Molecules 2023 Vol. 28 No. 18 Article 6491
A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity. The testing of these compounds against pathogens of the ESKAPE panel showed a good activity of lead compound 1-(2-methoxyethyl)-5-(5-nitro-2-furoyl)-3-(1,3-oxazol-5-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c] pyridine (13g), which is superior to nitrofurantoin. These results confirmed the benefit of combining a THPP scaffold with a ...
Added: January 26, 2024
Egorova K., Smirnova N., Toukach Ph., Glycobiology 2021 Vol. 31 No. 5 P. 524-529
We report the accomplishment of the first stage of the development of a novel manually curated database on glycosyltransferase (GT) activities, CSDB_GT. CSDB_GT (http://csdb.glycoscience.ru/gt.html) has been supplemented with GT activities from Saccharomyces cerevisiae. Now it provides the close-to-complete coverage on experimentally confirmed GTs from the three most studied model organisms from the three kingdoms: Plantae ...
Added: October 14, 2021
Plaksin M. A., Современные информационные технологии и ИТ-образование 2015 Т. 1 № 11 С. 302-309
Статья посвящена вопросу о включении в школьный курс информатики темы «параллельные вычисления». Упоминается ряд возникающих при этом проблем, рассматривается цель изучения темы, отбор материала, некоторые предложения по методике обучения, механизмы апробации предложенной методики и накопленный опыт. Не затрагивается вопрос о месте этого материала в учебной программе. ...
Added: November 29, 2015
Korotayev A., Вестник Института экономики Российской академии наук 2015 № 1 С. 149-162
The 19th century saw an explosive growth of the gap between the “First” and the “Third” World as regards per capita incomes and levels of life that has become to be known as the “Great Divergence”. In the 20th century the Great Divergence continued up to the early 1970s, and then – in the late ...
Added: December 3, 2015
Nersisyan S., Galatenko A. V., Galatenko V. V. et al., Plos One 2021 Vol. 16 No. 4 Article e0249424
Analysis of regulatory networks is a powerful framework for identification and quantification of intracellular interactions. We introduce miRGTF-net, a novel tool for construction of miRNA-gene-TF networks. We consider multiple transcriptional and post-transcriptional interaction types, including regulation of gene and miRNA expression by transcription factors, gene silencing by miRNAs, and co-expression of host genes with their ...
Added: May 10, 2021