Mutator Gene Model with Three Classes of Evolutionary States
The mutator gene model is one of the fundamental models of modern evolutionary dynamics. Usually, one considers a transition between two evolutionary regimes: the wild-type and mutator type. In this study, we introduce a hierarchy of three types with the transitions between them, considering an extra allele for the mutator gene. We examine both the unidirectional transitions between types and symmetric transition case. The analytical solution obtained is supported by numerical simulations.
This paper is devoted to a new class of differential games with continuous updating. It is assumed that at each time instant, players have or use information about the game defined on a closed time interval. However, as the time evolves, information about the game updates, namely, there is a continuous shift of time interval, which determines the information available to players. Information about the game is the information about motion equations and payoff functions of players. For this class of games, the direct application of classical approaches to the determination of optimality principles such as Nash equilibrium is not possible. The subject of the current paper is the construction of solution concept similar to Nash equilibrium for this class of differential games and corresponding optimality conditions, in particular, modernized Hamilton-Jacobi-Bellman equations.
We investigate the evolutionary model with recombination and random switches in the fitness function due to change in a special gene. The dynamical behaviour of the fitness landscape induced by the specific mutations is closely related to the mutator phenomenon, which, together with recombination, plays an important role in modern evolutionary studies. It is of great interest to develop classical quasispecies models towards better compliance with the observation. However, these properties significantly increase the complexity of the mathematical models. In this paper, we consider symmetric fitness landscapes for several different environments, using the Hamilton-Jacobi equation (HJE) method to solve the system of equations at a large genome length limit. The mean fitness and surplus are calculated explicitly for the steady-state, and the relevance of the analytical results is supported by numerical simulation. We consider the most general case of two landscapes with any values of mutation and recombination rates (three independent parameters). The exact solution of evolutionary dynamics is done via a solution of a fourth-order algebraic equation. For the more straightforward case with two independent parameters, we derive the solution using a quadratic algebraic equation. For the simplest case, when there are two landscapes with the same mutation and recombination rates, we derive some effective fitness landscape, mapping the model with recombination to the Crow-Kimura model.
In this paper, we discuss fitness landscape evolution of permanent replicator systems applying the hypothesis that the specific time of evolutionary adaptation of system parameters is much slower than the time of internal evolutionary dynamics. In other words, we suppose that the extremal principle of Darwinian evolution based on Fisher’s fundamental theorem of natural selection is valid for the steady-states of permanent replicator systems. Various cases illustrating this concept are considered.
This is an advanced text on ordinary differential equations (ODES) in Banach and more general locally convex spaces, most notably the ODEs on measures and various function spaces. It yields the concise exposition of the fundamentals with the fast, but rigorous and systematic transition to the up-fronts of modern research in linear and nonlinear partial and pseudo-differential equations, general kinetic equations and fractional evolutions. The level of generality is chosen to be suitable for the study of the most important nonlinear equations of mathematical physics, such as Boltzmann, Smoluchovskii, Vlasov, Landau-Fokker-Planck, Cahn-Hilliard, Hamilton-Jacobi-Bellman, nonlinear Schroedinger, McKean-Vlasov diffusions and their nonlocal extensions, mass-action-law kinetics from chemistry. It also covers nonlinear evolutions arising in evolutionary biology and mean-field games, optimization theory, epidemics and system biology, in general models of interacting particles or agents describing splitting and merging, collisions and breakage, mutations and the preferential-attachment growth on networks. The book is meant for final year undergraduate and postgraduate students and researchers in differential equations and their applications. A significant amount of attention is paid to the interconnections between various topics revealing where and how a particular result is used in other chapters or may be used in other contexts, as well as to the clarification of the links between the languages of pseudo-differential operators, generalized functions, operator theory, abstract linear spaces, fractional calculus and path integrals.
We consider the two-habitat quasispecies model, which describes evolutionary process with migration on the basis of the Eigen model. In the first habitat there is only one genotype, and here is an influx of the replicators from the first habitat to the second one with the rate h. We solve exactly the case of a single-peak fitness landscape in both habitats, when in the first habitat there are no mutations. The Eigen model version of the model is more adequately describes the real biological experiments than the Crow-Kimura model, as can be related to the serial transfer experiments in chemical reactor.