A Possible Sensory Interpretation of Alternate Motor Fibers Relating to Structural Reserve during Stroke Recovery

Kulikova Sofya; Nikulin Vadim; Dobrynina Larisa A; Nazarova Maria

doi:10.3389/fneur.2017.00355

Publications

Article

A Possible Sensory Interpretation of Alternate Motor Fibers Relating to Structural Reserve during Stroke Recovery

Frontiers in Neurology. 2017. Vol. 8. P. 1-4.

Kulikova S., Nikulin V., Dobrynina L. A., Nazarova M.

Recovery after stroke relates tightly to the white matter integrity. Currently, the main methodology for non-invasive white matter integrity assessment is diffusion-weighted magnetic resonance imaging (DW-MRI), a state-of-the-art approach which is, however, prone to multiple limitations. Using DW-MRI, it was demonstrated that many pathways including corticospinal tract (CST) and corpus callosum contribute to structural brain reserve after stroke, but only a few of these tracts were found to be useful in the clinical practice. The most widely known measure is an asymmetry of the fractional anisotropy (FA) in CST at the level of the internal capsule, which could be used for predicting motor recovery in acute stroke. Recently, a new complementary motor component of the structural reserve, the so-called alternate motor fibers (AMFs), was proposed for motor recovery prognosis in stroke patients, and it was even reported to correlate with the effect of the transcranial direct current stimulation in chronic stroke. Here, we would like to point out a possible additional sensory interpretation of the AMF that appears plausible after taking into account technical limitations of DW-MRI approach, which may potentially give rise to different interpretations of the same results.

Research target: Health Studies Basic Medicine

Priority areas: IT and mathematics

Language: English

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Keywords: stroke Alternate Motor Fibers sensory pathways recovery

Publication based on the results of: Активное и пассивное декодирование нейрональных процессов при выполнении когнитивных и нейроэкономических задач(2017)

Научно-техническая конференция студентов, аспирантов и молодых специалистов НИУ ВШЭ им. Е.В. Арменского. Материалы конференции.

М.: МИЭМ НИУ ВШЭ, 2016.

Added: Mar 7, 2016

Векторы человеческого развития в постсоциалистических странах Европы и СНГ: опыт количественной оценки. Ч.1

Added: Oct 3, 2013

Почему гастроэнтерология должна быть доказательной

Власов В. В. Доказательная гастроэнтерология. 2013. Т. 1. № 2. С. 101-110.

In the internal medicine wide spectrum the gastroenterology is one of the chapters, less enlightened by the scientific evidence. It does not mean that the practice of the grasntroenterology may ot be improved by the systematic use of the approaches of the evidence based medicine

Added: Mar 17, 2014

Sex Differences in Stroke Incidence, Prevalence, Mortality and Disability-Adjusted Life Years: Results from the Global Burden of Disease Study 2013

Vlassov V. Neuro-epidemiology. 2015. Vol. 45. No. 3. P. 203-214.

Background: Accurate information on stroke burden in men and women are important for evidence-based healthcare planning and resource allocation. Previously, limited research suggested that the absolute number of deaths from stroke in women was greater than in men, but the incidence and mortality rates were greater in men. However, sex differences in various metrics of stroke burden on a global scale have not been a subject of comprehensive and comparable assessment for most regions of the world, nor have sex differences in stroke burden been examined for trends over time. Methods: Stroke incidence, prevalence, mortality, disability-adjusted life years (DALYs) and healthy years lost due to disability were estimated as part of the Global Burden of Disease (GBD) 2013 Study. Data inputs included all available information on stroke incidence, prevalence and death and case fatality rates. Analysis was performed separately by sex and 5-year age categories for 188 countries. Statistical models were employed to produce globally comprehensive results over time. All rates were age-standardized to a global population and 95% uncertainty intervals (UIs) were computed. Findings: In 2013, global ischemic stroke (IS) and hemorrhagic stroke (HS) incidence (per 100,000) in men (IS 132.77 (95% UI 125.34-142.77); HS 64.89 (95% UI 59.82-68.85)) exceeded those of women (IS 98.85 (95% UI 92.11-106.62); HS 45.48 (95% UI 42.43-48.53)). IS incidence rates were lower in 2013 compared with 1990 rates for both sexes (1990 male IS incidence 147.40 (95% UI 137.87-157.66); 1990 female IS incidence 113.31 (95% UI 103.52-123.40)), but the only significant change in IS incidence was among women. Changes in global HS incidence were not statistically significant for males (1990 = 65.31 (95% UI 61.63-69.0), 2013 = 64.89 (95% UI 59.82-68.85)), but was significant for females (1990 = 64.892 (95% UI 59.82-68.85), 2013 = 45.48 (95% UI 42.427-48.53)). The number of DALYs related to IS rose from 1990 (male = 16.62 (95% UI 13.27-19.62), female = 17.53 (95% UI 14.08-20.33)) to 2013 (male = 25.22 (95% UI 20.57-29.13), female = 22.21 (95% UI 17.71-25.50)). The number of DALYs associated with HS also rose steadily and was higher than DALYs for IS at each time point (male 1990 = 29.91 (95% UI 25.66-34.54), male 2013 = 37.27 (95% UI 32.29-45.12); female 1990 = 26.05 (95% UI 21.70-30.90), female 2013 = 28.18 (95% UI 23.68-33.80)). Interpretation: Globally, men continue to have a higher incidence of IS than women while significant sex differences in the incidence of HS were not observed. The total health loss due to stroke as measured by DALYs was similar for men and women for both stroke subtypes in 2013, with HS higher than IS. Both IS and HS DALYs show an increasing trend for both men and women since 1990, which is statistically significant only for IS among men. Ongoing monitoring of sex differences in the burden of stroke will be needed to determine if disease rates among men and women continue to diverge. Sex disparities related to stroke will have important clinical and policy implications that can guide funding and resource allocation for national, regional and global health programs.

Added: Oct 29, 2015

Navigated repetitive transcranial magnetic stimulation in stroke rehabilitation (randomize double-blind sham-controlled study)

Червяков А. В., Пойдашева А. Г., Nazarova M. et al. Brain Stimulation. 2015. Vol. 8. No. 2. P. 331-332.

Navigated repetitive transcranial magnetic stimulation in stroke rehabilitation (randomize double-blind sham-controlled study)

Added: May 21, 2015

Фитнес в модернизации физкультурного образов. и его роль в оздоровлении населения России. Сборник материалов международной научно-практической конференции

СПб.: РГПУ им. А.И. Герцена, 2011.

The collection contains materials of the international scientific-practical conference, revealing the actual problems in the process of introducing fitness of physical education in modern conditions of its modernization and the transition to a multi-level education, defines the role fittnesa and its ability to rehabilitate the population of Russia.

Added: Jan 28, 2014

Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection

Debette S., Kamatani Y., Metso T. M. et al. Nature. 2014.

Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a major cause of ischemic stroke in young adults although relatively uncommon in the general population (incidence of 2.6/100,000 per year)1. Minor cervical traumas, infection, migraine and hypertension are putative risk factors1, 2, 3, and inverse associations with obesity and hypercholesterolemia are described3, 4. No confirmed genetic susceptibility factors have been identified using candidate gene approaches5. We performed genome-wide association studies (GWAS) in 1,393 CeAD cases and 14,416 controls. The rs9349379[G] allele (PHACTR1) was associated with lower CeAD risk (odds ratio (OR) = 0.75, 95% confidence interval (CI) = 0.69–0.82; P = 4.46 × 10−10), with confirmation in independent follow-up samples (659 CeAD cases and 2,648 controls; P = 3.91 × 10−3; combined P = 1.00 × 10−11). The rs9349379[G] allele was previously shown to be associated with lower risk of migraine and increased risk of myocardial infarction6, 7, 8, 9. Deciphering the mechanisms underlying this pleiotropy might provide important information on the biological underpinnings of these disabling conditions.

Added: Oct 23, 2014

Vulnerability to welfare change during economic shocks: Evidence from the 1998 Russian crisis

University of Essex, Department of Economics, 2002.

Using changes in consumption as a proxy for ‘vulnerability’ we identify the characteristics associated with vulnerability around the time of the 1998 Russian financial crisis. In addition, we examine the role of formal and informal safety nets in preserving individual well being. We apply quantile regression techniques in order to identify the characteristics associated with vulnerability across the two periods. Amongst those most vulnerable during the crisis were, less educated individuals living in urban areas, in households containing greater numbers of pensioners. Furthermore, we found that increases in home production and help from relatives acted to decrease vulnerability, especially amongst those suffering the largest changes in consumption. Following the crisis, amongst the least vulnerable were, better educated individuals, resident in urban areas, able to increase home production, and in receipt of improved pension payments and child benefits.

Added: Feb 8, 2016

Особенности исследований в психологической, педагогической практике и социальной работе. Международная научно-практическая конференция. IX Левитовские чтения. Сборник материалов

М.: Издательство МГОУ, 2014.

Added: Nov 29, 2014

Prototype X73-PHD 3-Lead ECG Device for Personal Healthcare

Korsakov I. N., Kuptsov S. M., Raznometov D. A. et al. Egyptian Computer Science Journal. 2013. Vol. 37. No. 7. P. 51-61.

This prototype development explains the challenges encountered during the ISO/IEEE 11073 standard implementation process. The complexity of the standard and the consequent heavy requirements, which have not encouraged software engineers to adopt the standard. The developing complexity evaluation drives us to propose two possible implementation strategies that cover almost all possible use cases and eases handling the standard by non-expert users. The first one is focused on medical devices (MD) and proposes a low-memory and low-processor usage technique. It is based on message patterns that allow simple functions to generate ISO/IEEE 11073 messages and to process them easily. MD act as X73 agent. Second one is focused on more powerful device X73 manager, which do not have the MDs' memory and processor usage constraints. The protocol between Agent and Manager is point-to-point and we can distribute the functionality between devices.

Developed both implementation X73 Agent and Manager will cut developing time for applications based on ISO/EEE 11073.

Added: Mar 20, 2014

Векторы человеческого развития в постсоциалистических странах Европы и СНГ: опыт количественной оценки. Ч.2

Added: Oct 3, 2013

Сабейские этюды

Коротаев А. В. М.: Восточная литература, 1997.

Added: Mar 9, 2013

Program Semantics, Specification and Verification: Theory and Applications. The conference materials. 6th International Computer Science Symposium in Russia

Edited by: V. Nepomniaschy, V. Sokolov. Yaroslavl: Yaroslavl State University, 2011.

Added: Mar 23, 2013

Разложения решений пятого уравнения Пенлеве вблизи его неособой точки

Брюно А. Д., Парусникова А. В. Институт прикладной математики им. М.В. Келдыша Российской академии наук, 2011. № 18.

Added: Apr 18, 2012

Многовариантный анализ процессов прокатки на базе компьютерного моделирования

Аксенов С. А., Чумаченко Е. Н., Сырчина О. О. Вестник Воронежского государственного технического университета. 2011. Т. 7. № 11.2. С. 62-64.

Added: Apr 12, 2012

Асимптотические разложения решений пятого уравнения Пенлеве

Парусникова А. В., Брюно А. Д. Институт прикладной математики им. М.В. Келдыша Российской академии наук, 2010. № 39.

Added: Apr 18, 2012

Локальные разложения решений пятого уравнения Пенлеве

Брюно А. Д., Парусникова А. В. Институт прикладной математики им. М.В. Келдыша Российской академии наук, 2010. № 72.

Added: Apr 18, 2012

Теория активных систем (ТАС-2014) [Электронный ресурс]: Материалы международной научно-практической конференции, 17–19 нояб. 2014 г, Москва

М.: ИПУ РАН, 2014.

Added: Jan 26, 2015

Применение информационных и космических технологий в задачах о движении небесных объектов

Чумаченко Е. Н., Кулагин В. П., Назиров Р. Р. и др. Информатизация образования и науки. 2011. № 3 (11). С. 178-187.

One of directions of activity of the scientifically-educational centre "SPACE" created by the Moscow state institute of electronics and mathematics (technical university) and Space research institute of the Russian Academy of Sciences is discussed. The general statements of problems connected with working out of models of movement of asteroids and comets taking into account not gravitational indignations and construction of models for measurement of trajectories are considered. On a space vehicle orbit in a vicinity of libration’s points the traffic control model is discussed with application of a solar sail with operated reflective characteristics.

Added: Apr 12, 2012

Анализ методов компьютерного моделирования механических испытаний

Чумаченко Е. Н., Аксенов С. А., Борхсениус С. С. Вестник Воронежского государственного технического университета. 2011. Т. 7. № 11.2. С. 9-11.

Added: Apr 12, 2012