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On Statistical Relationship between ADRA2A Expression and the Risk of Breast Cancer Relapse
Bulletin of Experimental Biology and Medicine. 2014. Vol. 157. No. 4. P. 454–458.
Shkurnikov M. Y., V. V. Galatenko, Lebedev A. E., Podol’skii V. E., Tonevitskii E. A., Mal’tseva D. V.
The search for novel parameters to predict the risk of relapse in breast cancer was conducted. Significant correlation between the risk of relapse and α-2A adrenergic receptor (ADRA2A) expression was revealed using public microarray datasets. This relationship was confirmed by validation on independent microarray dataset. It was found that when assessing the risk of BC relapse, the accuracy of prediction based solely on the expression of ADRA2A gene is close to that made using OncotypeDX and MammaPrint test systems. In this case, addition of only one or two supplemental prognostic markers (for instance, expression of SQLE gene or SQLE andDSCC1genes) to ADRA2A ensures the accuracy of prediction not inferior to reliability of these test systems.
Priority areas:
IT and mathematics
Language:
English
Zaikin A., Vlasenko D., Zakharov D. et al., Diagnostics 2026 Vol. 16 No. 17 P. 1–15
Background/Objectives: Synolitic graphs (SGs) were developed for task-based fMRI, where
edge weights encode the discriminative power of pairwise regional features; whether similar
information can be recovered from resting-state data was untested. We benchmarked
SGs for autism spectrum disorder (ASD) classification using the multisite ABIDE-I dataset
(871 subjects: 403 subjects with ASD, 468 typical controls; 17 sites; CC200 atlas). Methods:
Using ...
Added: August 27, 2026
Vlassov V., The Lancet Public Health 2026 Vol. 11 No. 9 P. e604–e629
Background
Understanding the size, gender composition, and cadre mix of the health workforce and how it has evolved across time and locations can inform policies for planning, recruitment, training, and retention of human resources for health (HRH), and improvement of access to the health-care workforce among populations. Using comparable and standardised data sources, we aim to ...
Added: August 25, 2026
Shabanov N., Kuricheva O., Kurbatova J. et al., / Series Working Papers SSRN "Department of Economics Ca’ Foscari University of Venice". 2026.
The carbon balance of an ecosystem is the difference between Gross Primary Productivity (GPP) and Ecosystem Respiration (Reco) as expressed by Net Ecosystem Exchange (NEE). While remote sensing retrievals of GPP have reached maturity, Reco estimation remains underexplored and ultimately cast bias on NEE. Here we present an end-to-end multi-scale analysis of the mechanism of ...
Added: August 21, 2026
Moshkin A., Fedorov M., Arlazarov V. et al., Algorithms 2026 Vol. 19 No. 7 Article 523
Artificial intelligence (AI) technologies, which are being actively developed in modern medicine today, increase the speed and quality of patient care. This article mainly seeks to demonstrate the use of various options of computer analysis of clinical images to solve practical problems of increasing the efficiency of routine diagnostics using retrospective analysis, as well as ...
Added: August 17, 2026
Shartova N., Mironova E., Geo Journal 2026 Vol. 91 Article 78
The historical timeline of urban development profoundly shapes the contemporary form and functionality of cities. Traditionally, cities were planned with limited consideration for the promotion of a healthy urban environment. Using Nizhny Novgorod, Russia, a city that has evolved from a medieval market town to an industrial centre and later into a multifunctional city with ...
Added: August 9, 2026
Vlassov V., JAMA - Journal of the American Medical Association 2026 Vol. 336 No. 8 P. 673–696
Importance Elevated low-density lipoprotein cholesterol (LDL-C) is a modifiable risk factor for cardiovascular disease, the leading cause of premature death worldwide. Assessing the LDL-C–related burden is critical for guiding prevention and treatment strategies.
Objectives To estimate the global, regional, and national burden of ischemic heart disease and ischemic stroke attributable to elevated LDL-C (relative to 35-54 mg/dL) from ...
Added: August 4, 2026
Andresyuk E., Porozova N., Londaridze G. D. et al., Frontiers in Oncology 2026 Vol. 16 Article 1875861
Inhibition of the PD-1/PD-L1 axis has become a clinical standard across multiple malignancies, yet durable benefit remains restricted to selected settings, and many biologically rational combinations fail to maintain clinical benefit in late-phase evaluation. This structured, registry-derived narrative review, supported by expert-guided interpretation, was designed to identify the most clinically meaningful development directions among strategies ...
Added: July 31, 2026
Maghsoohi A., Pavlov V., Rouse P. et al., Health Care Management Science 2026 Vol. 29 Article 37
As the numbers of older people (65 +) rise globally, the pressure on acute hospitals to provide efficient and effective care while addressing resource inequities increases. In this study we introduce Recognising Episodes of Acute Complexity in Health (REACH), a novel Automatic Machine Learning (AutoML)-based predictive model that prioritises older patients and assigns them to complex ...
Added: July 30, 2026
Ponomarenko A., / Series Computer Science "arxiv.org". 2025.
This paper addresses the challenge of merging hierarchical navigable small world (HNSW) graphs, a critical operation for distributed systems, incremental indexing, and database compaction. We propose three algorithms for this task: Naive Graph Merge (NGM), Intra Graph Traversal Merge (IGTM), and Cross Graph Traversal Merge (CGTM). These algorithms differ in their approach to vertex selection ...
Added: July 30, 2026
Vlassov V., The Lancet Public Health 2026 Vol. 11 No. 9 P. e589–e603
Background
Road injuries are a leading cause of mortality and morbidity worldwide. Years of international efforts have aimed to strengthen policy engagement, including the 2020 UN General Assembly's proclamation of the Second Decade of Action for Road Safety (2021–30), targeting a 50% reduction in road traffic deaths and serious injuries by 2030. The aim of this ...
Added: July 25, 2026
Авксентьева М. В., Ашихмин Я. И., Ашихмина О. В. et al., М.: ФГБУ "Издательство "Наука", 2023.
Предложены основные направления совершенствования планирования, организации и оплаты медицинской помощи, лекарственного обеспечения, информатизации и оценки технологий здравоохранения. Рекомендованы такие мероприятия, как конкретизация программы государственных гарантий бесплатного оказания гражданам медицинской помощи, создание системы общедоступного лекарственного обеспечения, использование клинико-статистических групп для оплаты медицинской помощи при ряде хронических неинфекционных заболеваний в амбулаторных условиях, формирование механизма привлечения соплатежей при ...
Added: July 16, 2026
Хайлова Ж. В., Омельяновский В. В., Терян Р. А. et al., Опухоли женской репродуктивной системы 2025 Т. 21 № 1 С. 86–105
Цель исследования – определить наиболее целесообразную стратегию скрининга и ранней диагностики рака шейки матки (РШМ) в Российской Федерации с точки зрения клинической (диагностической) и экономической эффективности.
Материалы и методы. Для оценки клинической (диагностической) эффективности различных стратегий скрининга проведен систематический обзор публикаций об исследованиях, оценивающих эффективность применения цитологического исследования и тестирования на вирус папилломы человека (ВПЧ) с целью диагностики ...
Added: July 16, 2026
Иванова А. А., Коган С. А., Горбунова Т. В. et al., Менеджер здравоохранения 2026 № 3 С. 96–105
The research r elev anc e is determined by the demand for telemedicine consultations (TMC) as one of health care digitalization pathways in Russian Federation. Telemedicine, regardless of the field, continues to prove its significant role, saving health resources without losing medical care quality. The TMC is regulated by federal level framework. Each year the ...
Added: July 16, 2026
Sun Z., Khvostikov A., Krylov A. et al., Machine Learning and Knowledge Extraction 2026 Vol. 8 No. 1 Article 8
Whole-slide histology images (WSIs) can exceed 100 k × 100 k pixels, making direct pixel-level segmentation infeasible and requiring patch-level classification as a practical alternative for downstream WSI segmentation. However, most approaches either treat patches independently, ignoring spatial and biological context, or rely on deep graph models prone to oversmoothing and loss of local tissue ...
Added: July 16, 2026
Хайлова Ж. В., Омельяновский В. В., Михайлов И. А. et al., Менеджер здравоохранения 2026 № 4 С. 41–52
The urgency of the problem of organizing effective medical care for cancer patients is determined by the steady trend of increasing incidence of malignant neoplasms, the high proportion of this pathology in the structure of overall mortality, as well as significant medical, demographic and socio-economic losses for society.Purpose of the st udy is to conduct ...
Added: July 16, 2026
Габриелян А. Р., Александрова О. Ю., Михайлов И. А., Здоровье мегаполиса 2026 Т. 7 № 2 С. 7–16
Objective. To evaluate the impact of a series of organizational measures for implementing innovative medical technology in a multidisciplinary hospital on patient quality of life based on patient self-assessments. Results. Patients who received care using innovative medical technology within a systemic organizational approach demonstrated a significantly higher level of overall satisfaction with the quality of care. ...
Added: July 16, 2026
Ахапкина Е. С., Омельяновский В. В., Тулупова О. Н. et al., Медицинские технологии. Оценка и выбор 2026 Т. 48 № 2 С. 70–77
OBJECTIVE
To analyze international approaches to assessing the labor complexity for different specialists with higher medical education (physicians).
MATERIAL AND METHODS
We performed a systematic searching and content analysis of foreign and national studies and documents devoted to labor complexity of different specialists with higher medical education (doctors). A group of experts among the authors of this study discussed and identified significant factors in assessing complexity.
RESULTS
There are 2 main systems to assess physician workload complexity in foreign countries. The first approach is based ...
Added: July 16, 2026
Turkina A., Vinogradova O., Lomaia E. et al., Annals of Hematology 2025 Vol. 104 P. 2707–2715
Vamotinib (PF-114) is a 3rd -generation, ATP-competitive oral tyrosine kinase inhibitor (TKI) active against wild-type and mutated BCR::ABL1 isoforms including BCR::ABL1T315I. We present final results of a phase-1 vamotinib dose-escalation study to identify maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) followed by expansion cohorts. 51 subjects with chronic myeloid leukaemia (CML) failing ≥ 1 2nd generation TKI or with BCR::ABL1T315I were ...
Added: July 16, 2026
Arina Bukina, Eritsyan K., Antonova N. et al., Frontiers in Psychology 2026 Vol. 17 Article 1824428
Background:
Numerous studies have shown that indigenous populations experience poorer health outcomes compared to people with other backgrounds. However, the interpretation of these disparities remains challenging due to differences in living conditions and social environments, as well as by potential measurement-related biases. Little is known about whether the underlying mechanisms of mental health outcomes differ between ...
Added: July 15, 2026
Vlassov V., The Lancet Infectious Diseases 2026 P. 1–12
Background
Tuberculosis (TB) is the leading global cause of death from a single infectious agent. Recent reductions in global health funding have threatened TB control, making comprehensive assessment of TB, HIV-related TB, and drug-resistant TB burdens before these disruptions essential for shaping effective responses. The WHO End TB Strategy sets targets of a 95% reduction in ...
Added: July 7, 2026
Piontkovski D., / Series arXiv "math". 2026.
A noncommutative projective variety is defined, following Artin and Zhang, by a graded coherent algebra 𝐴. The category of coherent sheaves is then the quotient qgr(𝐴) of the category of finitely presented graded modules by the subcategory of torsion modules. We consider the categorical and polynomial entropies of the Serre twist, that is, of the ...
Added: June 23, 2026
Piontkovski D., / Series arXiv "math". 2025.
If a symmetric multilinear algebra is weakly nil, then it is Engel. This result may be regarded as an infinite-dimensional analogue of the well-known Jacobian theorem, which states that if a polynomial mapping has a polynomial inverse, then its Jacobian matrix is invertible. This refines a theorem of Gerstenhaber and partially answers a question posed ...
Added: June 23, 2026
Shipilov F., Barnyakov A., Ivanov A. et al., / Series Physics "arxiv.org". 2026.
A fast simulation of the detector response is a vital task in high-energy physics (HEP). Traditional Monte-Carlo methods form the backbone of modern particle physics simulation software but are computationally expensive. We present a machine-learning-based approach to fast simulation of the Focusing Aerogel Ring Imaging Cherenkov (FARICH) detector response. Given a particle track and momentum, ...
Added: May 19, 2026
Derkacheva A., Sakirkina M., Kraev G. et al., /. 2026.
Comprehensive data on natural hazards and their consequences are crucial for effective for risk assessment, adaptation planning, and emergency response. However, many countries face challenges with fragmented, inconsistent, and inaccessible data, particularly regarding local-scale events. To address this data gap in Russia, we developed an end-to-end processing pipeline that scrapes news from various online sources, ...
Added: April 28, 2026