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Regular version of the site

Article

Cobra cytotoxins: determinants of antibacterial activity

Mendeleev Communications. 2015. Vol. 25. No. 1. P. 70-71.
Efremov R., Дубовский П. В., Воронцова О. В., Уткин Ю. Н., Арсеньев А. С., Феофанов А. В.

The investigation of antibacterial activity of three-finger cobra cytotoxins towards Gram-negative and Gram-positive bacteria showed no activity against the former species, whereas M. luteus was found most susceptible to cytotoxins. A correlation was revealed between this activity and hydrophobicity of the toxins (HTL scores), total charge and its distribution over the toxin molecule: the absence of Glu-16 residue and the presence of positively charged residues (Lys30/His31) in the tip of the loop 2