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## Nonlethal Fraction of Virus Population in Evolution Models with Lethal Mutations

Journal of the Physical Society of Japan. 2017. Vol. 86. No. 3. P. 1-5.

Yakushkina T., Saakian D.

Lethal mutations are very common in asexual evolution, both in RNA viruses and in the clonal evolution of cancer cells. In a special case of lethal mutations (truncated selection), after a critical total number of mutations the replicator (the virus or the cell) has no offspring. We consider the Eigen and Crow–Kimura models with truncated fitness landscapes, and calculate the fraction of viable replicators (that do have offspring) in the population. We derive a formula for the fraction of the population with nonlethal replicators for the case of a uniform distribution of lethal sequences in the sequence space. We assume that our results can be applied to the origin of life and cancer biology.

Priority areas:
mathematics

Language:
English

Yakushkina T., Saakian D., Hu C., Chinese Journal of Physics 2015 Vol. 53 No. 5-I P. 100904-1-100904-13

We investigate the dynamics of a molecular evolution model related to the mutator gene phenomenon. Here mutation in one gene drastically changes the properties of the whole genome. We investigated the Crow-Kimura version of the model, which can be mapped into a Hamilton-Jacobi equation. For the symmetric fitness landscape, we calculated the dynamics of the ...

Added: September 15, 2015

Yakushkina T., Saakian D., Physica A: Statistical Mechanics and its Applications 2018 Vol. 507 P. 470-477

In this paper, the impact of lethal mutations on evolutionary dynamics of asexual populations is analyzed. We suggest distinguishing different definitions of lethality, which lead to different mathematical formalizations of the microscopic model. Most of the studies focus on polyphasic lethality, meaning that individuals carrying lethal mutations have no offspring but consume common resources. In ...

Added: June 22, 2018

Yakushkina T., Saakian D., Bratus A. et al., Journal of the Physical Society of Japan 2015 Vol. 84 No. 6, Article number 064802 P. 064802-1-064802-7

Evolutionary games are used in various elds stretching from economics to biology. Most assume a constant payoff matrix, although some works also consider dynamic payoff matrices. In this article we propose a possibility of switching the system between two regimes with different sets of payoff matrices. Such a model can qualitatively describe the development of ...

Added: October 23, 2014

Saakian D., Yakushkina T., Hu C., Scientific Reports 2016 Vol. 6

We propose a modification of the Crow-Kimura and Eigen models of biological molecular evolution to include a mutator gene that causes both an increase in the mutation rate and a change in the fitness landscape. This mutator effect relates to a wide range of biomedical problems. There are three possible phases: mutator phase, mixed phase ...

Added: September 16, 2016

Yakushkina T., Saakian D., Journal of the Physical Society of Japan 2017 Vol. 86 P. 084801-1-084801-6

To describe virus evolution, it is necessary to define a fitness landscape. In this article, we consider the microscopic models with the advanced version of neutral network fitness landscapes. In this problem setting, we suppose a fitness difference between one-point mutation neighbors to be small. We construct a modification of the Wright–Fisher model, which is ...

Added: July 19, 2017

Yakushkina T., Saakian D., Chinese Journal of Physics 2019 Vol. 57 P. 309-313

We consider the two-habitat quasispecies model, which describes evolutionary process with migration on the basis of the Eigen model. In the first habitat there is only one genotype, and here is an influx of the replicators from the first habitat to the second one with the rate h. We solve exactly the case of a single-peak ...

Added: February 18, 2020

Sergeev A., Васильев А. Ю., Russian Mathematical Surveys 2013 Vol. 68 No. 3 P. 435-502

Teichmüller theory is a ramified and rapidly developing area of mathematics which has multiple connections with other directions in the mathematical sciences and with their applications, first and foremost in mathematical physics. In this survey the main lines of development of this theory and its applications to string theory are presented in a historical context.
Bibliography: 128 titles. ...

Added: April 9, 2015

Буров А.А., Герман А. Д., Косенко И. И., Космические исследования 2014 Т. 52 № 4 С. 307-312

The problem of planar oscillations of a pendulum with variable length suspended on the Moon’s surface is considered. It is assumed that the Earth and Moon (or, in the general case, a planet and its satellite, or an asteroid and a spacecraft) revolve around the common center of mass in unperturbed elliptical Keplerian orbits. We ...

Added: November 8, 2014

Gorsky A., Valba O. V., Journal of Complex Networks 2020 Vol. 8 No. 1 P. cnaa008

In this article, we show numerically the strong finite-size effects in exponential random graphs. Particularly, for the two-star model above the critical value of the chemical potential for triplets a ground state is a star-like graph with the finite set of hubs at network density p<0.5p<0.5 or as the single cluster at p>0.5p>0.5. We find that there exists ...

Added: August 28, 2020

М. : Издательство математико-механического факультета МГУ, 2009

В настоящий сборник вошли аннотации докладов участников XVI международной конференции «Ломоносов» по секции «Математика и механика». ...

Added: February 4, 2013

Belavin V., Geiko R., Journal of High Energy Physics 2017 Vol. 125 P. 1-13

We continue to investigate the dual description of the Virasoro conformal blocks arising in the framework of the classical limit of the AdS3/CFT2 correspondence. To give such an interpretation in previous studies, certain restrictions were necessary. Our goal here is to consider a more general situation available through the worldline approximation to the dual AdS gravity. ...

Added: August 31, 2017

Пенза : ПГУ, 2015

В сборник трудов включены доклады юбилейного ХХ-го Международного симпозиума «Надежность и качество», проходившего с 25 по 31 мая 2015 г. в городе Пензе.
Рассмотрены актуальные проблемы теории и практики повышения надежности и качества; эффективности внедрения инновационных и информационных технологий в фундаментальных научных и прикладных исследованиях, образовательных и коммуникативных системах и средах, экономике и юриспруденции; методов и ...

Added: May 31, 2015

BOSSY M., Jabir J. M., Electronic Communications in Probability 2018 Vol. 23 P. 1-14

In this paper, we prove a particle approximation, in the sense of the propagation of chaos, of a Lagrangian stochastic model submitted to specular boundary condition and satisfying the mean no-permeability condition. ...

Added: June 7, 2018

Akhmedov E., Physical Review D - Particles, Fields, Gravitation and Cosmology 2013 Vol. 87 No. 4 P. 044049

Following Krotov and Polyakov [ Nucl. Phys. B849 410 (2011)], we show that in global de Sitter space its isometry is broken by the loop IR divergences for any invariant vacuum state of the massive scalars. We derive a kinetic equation in global de Sitter space that follows from the Dyson-Schwinger equation of the Schwinger-Keldysh ...

Added: February 27, 2013

Budkov Y., Journal of Physics: Condensed Matter 2019 Vol. 31 P. 078002-078003

We reply to the comment on our paper by Budkov (2018 J. Phys.: Condens. Matter 30 344001). ...

Added: January 4, 2019

Зайцев В. И., Щавелин В. М., М. : ВИНИТИ РАН, 1985

Added: November 30, 2020

Семин С. В., Kurkina O. E., Kurkin A. A. et al., Труды НГТУ им. Р.Е. Алексеева 2012 № 2(95) С. 48-65

Purpose: Numerical modeling of internal baroclinic disturbances of different shapes in a model lake with variable depth, analysis of velocity field of wave-induced current, especially in the near-bed layer.
Approach: The study is carried out with the use of numerical full nonlinear nonhydrostatic model for stratified fluid.
Findings: The full nonlinear numerical modeling of internal wave dynamics ...

Added: October 6, 2012

Zhuzhoma E. V., Medvedev V., Исаенкова Н. В., Нелинейная динамика 2017 Т. 13 № 3 С. 399-412

В статье, используя методы теории динамических систем Морса–Смейла, авторы рассматривают топологическую структуру для точечно-зарядной модели магнитного поля областей фотосферы. Для произвольного количества зарядов (безотносительно к их местоположению) и не предполагая потенциальности поля <span data-mathml="B⃗ (следовательно, не используя конкретных формул), авторы приводят оценки, связывающие количества зарядов определенного типа с количеством нуль-точек. Для граничных оценок описывается топологическая структура магнитного ...

Added: October 12, 2017

49606783, Russian Journal of Mathematical Physics 2019 Vol. 26 No. 2 P. 168-173

The parameters of unstable short-living isotopes are studied from
the mathematical point of view. The values of the chemical potential
and activity parameters that determine the neutron halo arising when
the neutron separates from the nucleus of an unstable isotope are
calculated. The analogy between nuclear physics and economics is
considered from the point of view of such parameters as ...

Added: August 25, 2019

Окубо Ю. undefined., Journal of Physics: Conference Series 2017 Vol. 804 No. 012036 P. 1-8

We investigate the existence and the orthogonality of the generalized Jack symmetric functions which play an important role in the AGT relations. We show their orthogonality by deforming them to the generalized Macdonald symmetric functions. ...

Added: October 26, 2017

Kurkina O. E., Kurkin A. A., Rouvinskaya E. et al., Письма в Журнал экспериментальной и теоретической физики 2012 Т. 95 № 2 С. 98-103

Nonlinear wave dynamics is discussed using the extended modified Korteweg–de Vries equation that includes the combination of the third- and fifth- order terms and is valid for waves in a three-layer fluid with so-called symmetric stratification. The derived equation has solutions in the form of solitary waves of various polarities. At small amplitudes, they are ...

Added: August 24, 2012

Aseeva N., Gromov E., Onosova I. V. et al., JETP Letters 2016 Vol. 103 No. 10 P. 653-657

Evolution of solitons is addressed in the framework of a third-order nonlinear Schrödinger equation (NLSE), including nonlinear dispersion, third-order dispersion and a pseudo-stimulated-Raman-scattering (pseudo-SRS) term, i.e., a spatial-domain counterpart of the SRS term, which is well known as a part of the temporal domain NLSE in optics. In this context, it is induced by the ...

Added: June 28, 2016

Min Namkung, Younghun K., Scientific Reports 2018 Vol. 8 No. 1 P. 16915-1-16915-18

Sequential state discrimination is a strategy for quantum state discrimination of a sender’s quantum
states when N receivers are separately located. In this report, we propose optical designs that can
perform sequential state discrimination of two coherent states. For this purpose, we consider not
only binary phase-shifting-key (BPSK) signals but also general coherent states, with arbitrary prior
probabilities. Since ...

Added: November 16, 2020

Marshakov A., Миронов А. Д., Морозов А. Ю., Journal of Geometry and Physics 2011 Vol. 61 P. 1203-1222

We present a summary of current knowledge about the AGT relations for conformal blocks with additional insertion of the simplest degenerate operator, and a special choice of the corresponding intermediate dimension, when the conformal blocks satisfy hypergeometric-type differential equations in position of the degenerate operator. A special attention is devoted to representation of conformal block ...

Added: February 28, 2013