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Стандартизация фульвовой кислоты из торфа Нижегородской области
Медико-фармацевтический журнал «Пульс». 2024. Т. 26. № 7. С. 138–143.
Коннова М. А., Волков А. А., Мельникова Н. Б.
Fulvic acids (FA) are natural organic compounds obtained from the peat in the Nizhny Novgorod region
and used in the pharmacy, and require comprehensive studies not only to determine the authenticity, assay of the
main substance and impurities, but also to standardize the product. This is due, first of all, to the fact that
depending on the FA field, extraction methods, purification and drying, its chemical composition can vary
significantly. It complicates the analysis process. During standardization process, the optimal parameters for the quality of the product were determined, taking into account its chemical composition and biological activity. In
addition, there was a need to obtain standard samples and requirements for the FA quality assessing.
The work carried out the studies of the FA physicochemical properties, established key quality standards and
developed analytical methods that make it possible to determine the content of acidic (carboxyl and phenolic)
chemical groups in the product. The comparative analysis of various methods for FA extraction was carried out.
The Lamar method coupled with freeze drying, extraction methods with organic and inorganic reagents can affect
the FA composition and properties. It was revealed that, depending on the method of extraction of lowland peat
in the Nizhny Novgorod region, the product may contain different polymorphs of fulvic acids and a different
percentage of humic acids. The standardization carried out will allow us to provide the end consumer with a
quality product with proven effectiveness and safety.
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Гущина В. А., / Series chemrxiv-2023-vpzhz-v2 "ChemRxiv". 2023.
All-inorganic perovskite CsPbBr3 and Cs4PbBr6 nanoparticles are being intensively studied due to their unique properties and wide range of applications; however, however, the nature of their optical properties is not yet fully understood due to the difficulty of synthesis of singlephase nanoparticles. In this article we describe the features of the synthesis of single-phase particles ...
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A new approach to managing the extraction properties of eutectic solvents based on aliphatic alcohols is proposed. Aliphatic alcohols, when functioning as hydrogen bond donors within a eutectic solvent, significantly enhance the solvent’s efficiency in extracting metal ions. Conversely, when the alcohol acts as a hydrogen bond acceptor, its extraction properties diminish. Molecular modelling reveals ...
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Medicines based on compounds of iron, copper and zinc occupy a certain place in the pharmaceutical
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Fulvic acid as a fraction of humic substances is a hydrophilic molecule that can form aggregated particles in solutions. This can cause problems in the development of topical formulations such as ointments, gels and transdermal patches. In such cases, the development of formula-tions improving the penetration of small polar molecules through the lipophilic stratum corneum ...
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Properties of fulvic acid (FA) extracted from the peat of the Nizhny Novgorod region of Russia by ultrasonic extraction with alkaline or ethanol solutions and further purification were studied in the paper. The purification of FA by the Lamar method was shown to possibly lead to the formation of FA polymorphs of the same composition ...
Added: September 8, 2025