The main goal of this book is to deepen our knowledge and share opinions on real SME’s needs, different approaches to technology parks, incubators and entrepreneurial centres, and their role in the success of startups in different countries. To illuminate these issues we have been using the Triple-Helix perspective developed by Loet Leydesdorff and Henry Etzkowitz. Specifically, our studies aim at deciphering the key success factors of incubation programs in different countries around Europe as compared with the best practices round the world. Other research deals with the impact of processes and activities that take place in parks, centres and incubators on the speed and magnitude of startups’ success. Furthermore, we identify the differences between different types of incubators (e.g., university science park, technology park, entrepreneurial incubator, independent commercial incubator, regional business incubator, company-internal incubator, virtual incubator) and their subsequent effect on startups’ sustainability.