The level of gene expression and the protein content of tyrosine hydroxylase and dopamine β-hydroxylase were determined. In the perinatal period of rats, when noradrenaline functions as a morphogenetic factor, the level of gene expression of these enzymes increased and the content of protein products of these genes was almost unchanged, indicating the difference in the regulatory mechanisms of their transcription and translation.
Original Russian Text © N.S. Bondarenko, A.R. Murtazina, Yu.O. Nikishina, A.Ya. Sapronova, M.V. Ugrumov, 2017, published in Doklady Akademii Nauk, 2017, Vol. 472, No. 3, pp. 341–344.
Spontaneous and K+-stimulated release of noradrenaline from the hypothalamus, adrenal gland, and organ of Zuckerkandl under their flowing incubation was investigated in the perinatal period of ontogenesis of rats. The results suggest that, during the investigated period of ontogenesis, adrenal glands are the main source of noradrenaline in the blood, whereas the contributions of the organ of Zuckerkandl and the brain are not as significant and change during this period. © 2016, Pleiades Publishing, Ltd.